Relationship of Bladder Pain With Clinical and Urinary Markers of Neuroinflammation in Women With Urinary Urgency Without Urinary Incontinence

Soriano, Alex; Andy, Uduak U.; Hassani, Daisy; Whitmore, Kristene; Harvie, Heidi S.; Malykhina, Anna P.; Arya, Lily A.

doi:10.1097/spv.0000000000000951

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…• Biological factors: in which pain reflects the severity of tissue inflammation and damage (neurological, mucocutaneous, anorectal, muscular, vascular, endocrine, and immunitary) [23][24][25]. Inflammation in the peripheral tissues and nervous system (neuroinflammation) is the common denominator of all medical conditions when pain is the leading symptom [26,27].…”

Section: Etiological Complexity Of Sexual Painmentioning

confidence: 99%

Sexual Pain Disorders, Vestibulodynia, and Recurrent Cystitis: The Evil Trio

Graziottin

Maseroli

2022

Practical Clinical Andrology

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Sexual pain/penetration disorders are often comorbid with recurrent/post-coital cystitis and spontaneous or provoked vestibulodynia or vulvar pain. The figures vary from 34.7–60%, Uropathogenic Escherichia coli (UPEC) is responsible for 85–90% of recurrent cystitis cases. Antibiotic treatment is becoming ineffective in the long term. To maximize therapeutic outcomes, a different strategy is worth considering. Common pathophysiological denominators of the three clusters of symptoms present in a patient should be identified. These include (1) predisposing factors: endocellular pathogenic biofilm of the uropathogenic Escherichia coli (UPEC), hyperactive pelvic floor, bowel problems, including irritable bowel syndrome and constipation, intestinal and vaginal dysbiosis, diabetes/familiarity with diabetes, and loss of sexual hormones after menopause; (2) precipitating factors: intercourse, constipation, and cold; and (3) maintaining factors: diagnostic omissions and minimalistic treatment approach. A targeted multimodal therapeutic strategy should then be based on accurate diagnosis. A comprehensive and skilled approach can optimize anticipation of comorbidities and offer better clinical outcomes for women, where sexual pain/penetration disorders, comorbid recurrent and/or post-coital cystitis, and vestibulodynia/vulvar pain are addressed synergistically, the sooner the better.

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Section: Etiological Complexity Of Sexual Painmentioning

confidence: 99%

Sexual Pain Disorders, Vestibulodynia, and Recurrent Cystitis: The Evil Trio

Graziottin

Maseroli

2022

Practical Clinical Andrology

View full text Add to dashboard Cite

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Cytokines in Bladder Pain Syndrome: A Review of the Literature

Lemmon,

Kyrgiou,

Mullins

et al. 2024

Int Urogynecol J

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Relationship of Pain Catastrophizing With Urinary Biomarkers in Women With Bladder Pain Syndrome

Soriano

Allen

Malykhina

et al. 2021

Female Pelvic Med Reconstr Surg

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Objectives Brain-derived neurotrophic factor (BDNF) has been implicated in central neurological processes. We hypothesize that greater pain catastrophizing is associated with higher urinary BDNF levels in women with bladder pain syndrome. Methods A secondary analysis of a database of women with urinary urgency was conducted. We identified women who met AUA criteria of bladder pain syndrome. Urinary symptoms, pain catastrophizing, and neuropathic pain were measured using the Female Genitourinary Pain Index, Pain Catastrophizing Scale and painDETECT questionnaires respectively. The relationship of the catastrophizing score with urinary BDNF (primary outcome) and other urinary biomarkers, including nerve growth factor (NGF), vascular endothelial growth factor (VEGF), and osteopontin, was evaluated using univariable and multivariable analyses. Results In 62 women with bladder pain syndrome, 15 (24%) reported pain catastrophizing symptoms (Pain Catastrophizing Scale score >30). Higher catastrophizing scores were associated with worse urinary symptoms, greater pelvic pain, greater neuropathic pain, and worse quality of life scores (all P < 0.01). On multivariable analysis, after controlling for age, body mass index and urinary symptoms, a higher pain catastrophizing score was associated with lower BDNF (P = 0.04) and lower VEGF levels (P = 0.03). Urinary urgency was associated with a higher NGF level (P = 0.04) while bladder pain was associated with higher levels of NGF (P = 0.03) and VEGF (P = 0.01). Conclusions Neuroinflammatory mechanisms contribute to the central processing of pain in women with bladder pain syndrome. Worse urinary symptoms are associated with higher NGF and VEGF levels, but worse pain catastrophizing is associated with lower BDNF and VEGF levels. Urinary BDNF levels may be useful in phenotyping women who have central augmentation of pain processing.

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Relationship of Bladder Pain With Clinical and Urinary Markers of Neuroinflammation in Women With Urinary Urgency Without Urinary Incontinence

Cited by 4 publications

References 30 publications

Sexual Pain Disorders, Vestibulodynia, and Recurrent Cystitis: The Evil Trio

Sexual Pain Disorders, Vestibulodynia, and Recurrent Cystitis: The Evil Trio

Cytokines in Bladder Pain Syndrome: A Review of the Literature

Relationship of Pain Catastrophizing With Urinary Biomarkers in Women With Bladder Pain Syndrome

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