1978
DOI: 10.1128/jvi.28.3.697-709.1978
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Relationship of Bacillus subtilis DNA polymerase III to bacteriophage PBS2-induced DNA polymerase and to the replication of uracil-containing DNA

Abstract: In vivo studies of PBS2 phage replication in a temperature-sensitive Bacillus subtilis DNA polymerase III (Pol III) mutant and a temperature-resistant revertant of this mutant have suggested the possible involvement of Pol III in PBS2 DNA synthesis. Previous results with 6-(p-hydroxyphenylazo)-uracil (HPUra), a specific inhibitor of Pol III and DNA replication in uninfected cells, suggest that Pol III is not involved in phage DNA replication, due to its resistance to this drug. Experiments were designed to exa… Show more

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Cited by 6 publications
(1 citation statement)
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“…Such behavior might have been anticipated for PBS1 DNA, the structure of which is similar to that of the corresponding thymine-containing DNA (4,12); its sensitivity to nucleases is also unaltered (9,24), so that its affinity for at least these enzyme proteins is unaffected by replacement of thymine by uracil.…”
Section: Resultsmentioning
confidence: 74%
“…Such behavior might have been anticipated for PBS1 DNA, the structure of which is similar to that of the corresponding thymine-containing DNA (4,12); its sensitivity to nucleases is also unaltered (9,24), so that its affinity for at least these enzyme proteins is unaffected by replacement of thymine by uracil.…”
Section: Resultsmentioning
confidence: 74%