Relationship of atopic dermatitis with stroke and myocardial infarction

Yuan, Min; Cao, Weijun; Xie, Xing; Zhou, Huang-Yan; Wu, Xiao‐Mu

doi:10.1097/md.0000000000013512

Cited by 25 publications

(20 citation statements)

References 48 publications

(85 reference statements)

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“…A possible explanation could be cellular pathways such as mast cell release linking allergy in asthma with coronary heart disease 36. The hypothesis of inflammatory pathways as a possible common mechanism is compatible with at recent finding of an increased risk only present in individuals with active asthma37 and also in line with observed associations between atopic dermatitis and myocardial infarction 38. Furthermore, the observed association between presence of allergy in asthma and coronary heart disease could be dependent on the late-phase reaction and chronic allergic inflammation involving mediators such as transforming growth factor α,39 a cytokine that has been associated with coronary heart disease 40.…”

Section: Discussionsupporting

confidence: 76%

Coronary heart disease and heart failure in asthma, COPD and asthma-COPD overlap

Ingebrigtsen¹,

Marott

Vestbo

et al. 2020

BMJ Open Resp Res

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IntroductionWe investigated risk of coronary heart disease and heart failure in phenotypes of obstructive airway disease.MethodsAmong 91 692 participants in the Copenhagen General Population Study, 42 058 individuals were classified with no respiratory disease, and 11 988 individuals had different phenotypes of obstructive airways disease: asthma with early onset or late-onset, chronic obstructive pulmonary disease (COPD) with forced expiratory volume in one second (FEV1) above or below 50% of predicted value (%p) or asthma-COPD overlap (ACO).ResultsDuring a mean follow-up of 5.7 years we registered 3584 admissions for coronary heart disease and 1590 admissions for heart failure. Multivariable Cox regression analyses of time to first admission were used with a two-sided p value of 0.05 as significance level. Compared with no respiratory disease the highest risks of coronary heart disease and heart failure were observed in ACO with late-onset asthma and FEV1 <50% p, HR=2.2 (95% CI 1.6 to 3.0), and HR=2.9 (95% CI 2.0 to 4.3), respectively. In COPD with FEV1 above 50% p the HRs were 1.3 (95% CI 1.2 to 1.5) for coronary heart disease and 1.9 (95% CI 1.6 to 2.3) for heart failure. Asthma associated with increased risks of coronary heart disease and heart failure, however, in asthma without allergy the HR was 1.1 (95% CI 0.7 to 1.6) for coronary heart disease while individuals with allergy had an HR of 1.4 (95% CI 1.1 to 1.6).ConclusionsRisks of coronary heart disease and heart failure were increased in asthma, COPD and ACO. In asthma, the risk of coronary heart disease depended on presence of allergy. We suggest that cardiovascular risk factors should be assessed systematically in individuals with obstructive airway disease with the potential to facilitate targeted treatments.

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Section: Discussionsupporting

confidence: 76%

Coronary heart disease and heart failure in asthma, COPD and asthma-COPD overlap

Ingebrigtsen¹,

Marott

Vestbo

et al. 2020

BMJ Open Resp Res

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“…The underlying mechanism for this small association remains unclear. As previous studies have reported that people with severe atopic eczema are already at higher risk of cardiovascular disease, 5,6 our findings are largely reassuring for patients and practitioners.…”

Section: Discussionsupporting

confidence: 80%

Atopic eczema and obesity: a population‐based study*

et al. 2020

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K.A. reports and receives consulting fees from TARGET DERM, a company starting an atopic dermatitis disease registry, and receives grant funding (through her University) from Pfizer. L.S. is a trustee of the British Heart Foundation (BHF), and reports grants outside of the submitted work from Wellcome, the Medical Research Council, National Institute for Health Research, GSK, the BHF and Diabetes UK. S.M.L. reports grants from the Wellcome Trust, and received an Innovative Medicines Initiative BIOMAP Horizon 2020 grant during the conduct of the study. A.A., K.E.M., Y.S., A.M. and A.R. declare they have no conflicts of interest. A.A. and K.E.M. contributed equally to the study and are joint first authors. S.M.L. had the original idea for the study. All authors were involved in the study design. K.M. undertook initial data management. A.A. undertook subsequent SummaryBackground Atopic eczema is a common chronic inflammatory skin disease. Research suggests an association between atopic eczema and obesity, with inconsistent evidence from European populations. Objectives To explore the association between diagnosed atopic eczema and being overweight or obese, and whether increased atopic eczema severity was associated with higher body mass index. Methods We undertook a cross-sectional analysis within a cohort of adults (matched by age, sex and general practice) with and without a diagnosis of atopic eczema. We used primary care (Clinical Practice Research Datalink Gold) and linked hospital admissions data (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016). We used conditional logistic regression to compare the odds of being overweight or obese (adjusting for confounders and potential mediators) in those with atopic eczema (mild, moderate and severe, and all eczema) vs. those without. Results We identified 441 746 people with atopic eczema, matched to 1 849 722 without. People with atopic eczema had slightly higher odds of being overweight or obese vs. those without [odds ratio (OR) 1Á08, 95% confidence interval (CI) 1Á07-1Á09] after adjusting for age, asthma and socioeconomic deprivation. Adjusting for potential mediators (high-dose glucocorticoids, harmful alcohol use, anxiety, depression, smoking) had a minimal impact on effect estimates (OR 1Á07, 95% CI 1Á06-1Á08). We saw no evidence that odds of being overweight or obese increased with increasing atopic eczema severity, and there was no association in people with severe eczema. Conclusions We found evidence of a small overall association between atopic eczema and being overweight or obese. However, there was no association with obesity among those with the most severe eczema. Our findings are largely reassuring for this prevalent patient group who may already have an increased risk of cardiovascular disease.

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“…Ye et al provided similar evidence in humans [ 40 ]. In the last 5 years, studies of psoriasis [ 6 ] and dermatitis [ 7 ] have similarly determined that skin inflammation likely increases the risk of cardiovascular disease. Therefore, the development of a skin-specific DNAm age predictor can offer a powerful tool for the comprehension of skin diseases and how it may influence overall organismal health status and DNAm age.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, additional factors beyond time have been shown to influence DNAm age, such as genetic diseases [ 3 , 4 ], infectious diseases [ 5 ], inflammatory disorders [ 6 , 7 ], and lifestyle factors, such as exercise and obesity [ 8 ], to cite a few. DNAm data was also significantly correlated to mortality risk [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging

Boroni

Zonari²,

Oliveira³

et al. 2020

Clin Epigenet

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Background DNA methylation (DNAm) age constitutes a powerful tool to assess the molecular age and overall health status of biological samples. Recently, it has been shown that tissue-specific DNAm age predictors may present superior performance compared to the pan- or multi-tissue counterparts. The skin is the largest organ in the body and bears important roles, such as body temperature control, barrier function, and protection from external insults. As a consequence of the constant and intimate interaction between the skin and the environment, current DNAm estimators, routinely trained using internal tissues which are influenced by other stimuli, are mostly inadequate to accurately predict skin DNAm age. Results In the present study, we developed a highly accurate skin-specific DNAm age predictor, using DNAm data obtained from 508 human skin samples. Based on the analysis of 2,266 CpG sites, we accurately calculated the DNAm age of cultured skin cells and human skin biopsies. Age estimation was sensitive to the biological age of the donor, cell passage, skin disease status, as well as treatment with senotherapeutic drugs. Conclusions This highly accurate skin-specific DNAm age predictor constitutes a holistic tool that will be of great use in the analysis of human skin health status/molecular aging, as well as in the analysis of the potential of established and novel compounds to alter DNAm age.

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Relationship of atopic dermatitis with stroke and myocardial infarction

Cited by 25 publications

References 48 publications

Coronary heart disease and heart failure in asthma, COPD and asthma-COPD overlap

Coronary heart disease and heart failure in asthma, COPD and asthma-COPD overlap

Atopic eczema and obesity: a population‐based study*

Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging

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