Relationship of arterial stiffness and early mild diastolic heart failure in general middle and aged population

Kang, Sheng; Fan, Huimin; Li, Jue; Fan, Lieying; Miao, Aiyu; Bao, Yan; Wu, Lezhou; Zhu, Yun; Dai-fu, Zhang; Liu, Zhongmin

doi:10.1093/eurheartj/ehq296

Cited by 65 publications

(60 citation statements)

References 42 publications

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“…Although in elderly patients and patients with hypertension LV hypertrophy, 5 BP, 23 and arterial stiffness 24 are major factors leading to diastolic dysfunction and subsequently to HF with preserved EF, in our AO asymptomatic subjects, we could show that increased LV mass and diastolic dysfunction could be detected early, before LV hypertrophy, hypertension, and arterial stiffening can be diagnosed. Furthermore, increased collagen type III turnover was observed in the study participants with diastolic dysfunction.…”

Section: Cardiac and Arterial Remodeling: Changes In Structure And Fucontrasting

confidence: 49%

Features of Cardiac Remodeling, Associated With Blood Pressure and Fibrosis Biomarkers, Are Frequent in Subjects With Abdominal Obesity

et al. 2014

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White subjects with AO (waist circumference >94 cm for men and >80 cm for women) 2 aged 40 to 65 years and age-and sex-matched healthyAbstract-Incidence and prevalence of abdominal obesity (AO) are growing exponentially. Subjects with AO are at higher risk of developing heart failure. The purpose of the study was to investigate early changes in cardiac and arterial structure and function and extracellular matrix biomarkers in normotensive healthy subjects with AO. Subjects with AO and age-and sex-matched controls underwent echocardiography, MRI (cardiac remodeling index), carotid intima-media thickness, pulse wave velocity, and blood fibrosis biomarkers measurements. We enrolled 87 subjects with AO and 53 controls. Although normotensive, subjects with AO had higher systolic blood pressure (BP; 122±11 versus 116±11 mm Hg; P=0.003), left ventricular mass (94±24 versus 84±21 g; P=0.034), and cardiac remodeling index (0.67±0.16 versus 0.60±0.10 g/mL; P=0.026) but unchanged carotid intima-media thickness and pulse wave velocity. Diastolic dysfunction (E′ <10 cm/s) could be detected in 38% of subjects with AO (4% in controls). Left ventricular remodeling, as assessed by cardiac remodeling index, was positively and independently associated with higher BP (systolic BP and mean arterial pressure but not diastolic BP) and AO. Higher BP, AO, and procollagen-III-N-terminal peptide (≥2.4 ng/mL) concentrations (odds ratio, 4.15 [1.42-12.2]; P=0.01) were positively associated with diastolic dysfunction. Early cardiac structural remodeling, fibrosis, and diastolic dysfunction were detectable in healthy subjects with AO. Higher BP, procollagen-III-N-terminal peptide, and AO were independently associated with early cardiac structural and functional changes. It is to be investigated whether in subjects with AO, an early BP reduction, even if normotensive, combined with weight loss may avoid adverse cardiac remodeling and protect against progression to heart failure. From the INSERM, Center d'Investigation Clinique CIC-P 9501, Nancy, France (R.E., P.R., A.K.S., C.A., K.K., R.F., F.Z.); CHU-Nancy, Department of Cardiology, Nancy, France (F.Z.); Université de Lorraine, Nancy, France (P.R., D.M., P.Y.M., F.Z.); INSERM, U1116, Nancy, France (P.R., P.Y.M., F.Z.); Clermont Université, Université d'Auvergne, UMR6284, Clermont-Ferrand, France (R.E.); CHU Clermont-Ferrand, Department of Cardiology, ClermontFerrand, France (R.E.); CHU-Nancy, Department of Radiology, Nancy, France (D.M.); CHU-Nancy, Department of Nuclear Medicine, Nancy, France (P.Y.M.); and INSERM, U947, Nancy, France (D.M. Metabolic PhenotypingBlood was sampled between 8 and 10 am after maintaining a supine position for 30 minutes and the following were assessed: fasting glucose, oral glucose tolerance test (to exclude patients with diabetes mellitus), glycohemoglobin, serum creatinine (estimated glomerular filtration rate by the MDRD [Modification of the Diet in Renal Disease] formula), 9 ultrasensitive C-reactive protein, alanine aminotransferase, lipid profile, leptin, ...

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Section: Cardiac and Arterial Remodeling: Changes In Structure And Fucontrasting

confidence: 49%

Features of Cardiac Remodeling, Associated With Blood Pressure and Fibrosis Biomarkers, Are Frequent in Subjects With Abdominal Obesity

et al. 2014

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“…40 Mechanisms explaining its predictive value can be inferred by its associations with arterial and overall CV performance. baEI is associated with left ventricular function, 41 left ventricular hypertrophy, 6,42 and impaired coronary perfusion. 43 Furthermore, baEI is an independent predictor of longitudinal increases in BP, as well as of new onset of hypertension and microalbuminuria.…”

Section: Baei: Clinical Implicationsmentioning

confidence: 99%

Prediction of Cardiovascular Events and All-Cause Mortality With Brachial-Ankle Elasticity Index

et al. 2012

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Abstract-Brachial-ankle elasticity index (baEI; also known as brachial-ankle pulse wave velocity) has been proposed as a surrogate end point for cardiovascular disease. We performed a meta-analysis of longitudinal cohort studies for determining the ability of baEI to predict risk of cardiovascular events and all-cause mortality and dissecting factors influencing this predictive ability. Multiple online databases, reference lists from retrieved articles, and abstracts from international cardiovascular conventions were searched until April 2012. Longitudinal cohort studies that reported associations of baEI with clinical risk were included. Of the 18 studies included (8169 participants; mean follow-up, 3.6 years), 15 reported results on total cardiovascular events (5544 individuals), 7 on cardiovascular mortality (2274 individuals), and 9 on all-cause mortality (5097 individuals). The pooled relative risks for total cardiovascular events, cardiovascular mortality, and all-cause mortality were 2.95 (95% CI, 1.63-5.33), 5.36 (95% CI, 2.17-13.27), and 2.45 (95% CI, 1.56 -3.86), respectively, for subjects with high versus low baEI (all PϽ0.001). An increase in baEI by 1 m/s corresponded with an increase of 12%, 13%, and 6% in total cardiovascular events, cardiovascular mortality, and all-cause mortality, respectively. We conclude that baEI is associated with increased risk of total cardiovascular events and all-cause mortality. Issues such as expansion of data to non-Asian populations, validation of path length estimation, determination of reference values, and prospective comparison with carotid-femoral pulse wave velocity remain to be resolved. (Hypertension. 2012;60:556-562.) • Online Data Supplement Key Words: brachial-ankle pulse wave velocity Ⅲ cardiovascular risk Ⅲ cardiovascular disease Ⅲ mortality Ⅲ prediction Ⅲ meta-analysis Ⅲ arterial stiffness A rterial stiffness is increasingly recognized as a surrogate end point for cardiovascular (CV) disease and is associated with presence of CV risk factors and atherosclerotic disease.1 Arterial stiffness can be measured with noninvasive, reproducible, and relatively inexpensive techniques, and, thus, it is suitable for large-scale studies. Carotid-femoral pulse wave velocity (PWV; cfPWV) is considered the goldstandard method for assessing aortic stiffness 2 and predicts future CV events and all-cause mortality in a strong and independent manner. Brachial-ankle PWV, calculated as the ratio of the distance between the brachial and the tibial artery divided by the transit time between these 2 arteries, has been proposed as an additional arterial biomarker of CV risk. PWV is classically referred to "segmental stiffness." Because of the complexity of the anatomic course of the brachial-ankle arterial system, it is unclear whether the term brachial-ankle PWV is appropriate to define any particular segmental stiffness or whether it is just the ratio of a virtual brachial-ankle distance and the measurement of the brachial-ankle transit time. For this reason, this index will ...

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“…This type of heart failure often occurs in patients who have previously suffered myocardial infarction ). The relationship of arterial stiffness to LV function has been studied for heart failure with preserved EF to elucidate the contribution of arterial stiffness to onset of heart failure with preserved EF (Desai et al 2009;Kang et al 2010). Some previous studies demonstrated the relationship between arterial stiffness and LV function by measuring pulse wave velocity (Tsioufis et al 2005;).…”

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confidence: 99%

Correlation of Arterial Stiffness to Left Ventricular Function in Patients with Reduced Ejection Fraction

Noguchi

Masugata

Senda

et al. 2011

Tohoku J. Exp. Med.

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Heart failure has been divided into heart failure with preserved left ventricular (LV) ejection fraction (EF) and heart failure with reduced EF, because the pathophysiologies of the two conditions are different. Cardio-ankle vascular index (CAVI) is a new indicator of arterial stiffness, and the most conspicuous feature of CAVI is its independence of blood pressure at the time of measurement. Arterial stiffness has been considered to increase LV afterload, which requires special care to avoid the onset of heart failure. We compared the correlation of arterial stiffness as assessed by CAVI to LV function in 44 hypertensive patients with preserved EF (EF: 71 ± 7%) and 31 patients with reduced EF (48 ± 8%). All of patients with reduced EF had history of both hypertension and myocardial infarction. Using Doppler echocardiography, LV diastolic and systolic function was evaluated by measuring peak early diastolic mitral annular velocity (e') and global LV peak systolic longitudinal strain (GPSLS), respectively. In patients with preserved EF, CAVI was correlated with e' (r = −0.313, p = 0.038), but not with GPSLS (r = 0.207). By contrast, CAVI was correlated with GPSLS (r = 0.604, p < 0.001) as well as e' (r = −0.393, p = 0.029) in patients with reduced EF. Thus, patients with reduced EF showed a closer correlation of arterial stiffness to LV function compared with patients with preserved EF. Therefore, hypertensive patients with reduced EF require a stricter regimen for treating arterial stiffness than their counterparts with preserved EF.

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Relationship of arterial stiffness and early mild diastolic heart failure in general middle and aged population

Cited by 65 publications

References 42 publications

Features of Cardiac Remodeling, Associated With Blood Pressure and Fibrosis Biomarkers, Are Frequent in Subjects With Abdominal Obesity

Features of Cardiac Remodeling, Associated With Blood Pressure and Fibrosis Biomarkers, Are Frequent in Subjects With Abdominal Obesity

Prediction of Cardiovascular Events and All-Cause Mortality With Brachial-Ankle Elasticity Index

Correlation of Arterial Stiffness to Left Ventricular Function in Patients with Reduced Ejection Fraction

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