Relationship of Aortic Wall Distensibility to Mitral and Aortic Valve Calcification: The Multi-Ethnic Study of Atherosclerosis

Cohoon, Kevin P.; Criqui, Michael H.; Budoff, Matthew J.; Lima, João A.C.; Blaha, Michael J.; Decker, Paul A.; Durazo, Ramón; Liu, Kiang; Kramer, Holly

doi:10.1177/0003319717730636

Cited by 7 publications

(4 citation statements)

References 35 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that the link between VC and diastolic dysfunction might be the impairment of arterial function. Several reports showed an association between VC and arterial stiffening 21,22 . An impairment of vascular function might lead to increased ventricular load with increasing mass, impaired relaxation and increased filling pressure and consequently pulmonary hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports showed an association between VC and arterial stiffening. 21,22 An impairment of vascular function might lead to increased ventricular load with increasing mass, impaired relaxation and increased filling pressure and consequently pulmonary hypertension. However, it could also be speculated that these pathophysiologic abnormalities might represent different consequences of a single underlying and unifying pathologic process.…”

Section: Ta B L Ementioning

confidence: 99%

See 1 more Smart Citation

Heart valve calcification and cardiac hemodynamics

Rossi

Barbieri²,

Benfari

et al. 2021

Echocardiography

View full text Add to dashboard Cite

Heart valve calcification (VC) is associated with increased cardiovascular risk, but the hemodynamic and functional profile of patients affected by VC has not been fully explored. Methods:The study population was formed by consecutive unselected patients included in seven echocardiographic laboratories in a 2-week period. A comprehensive echocardiographic examination was performed. VC was defined by the presence of calcification on at least one valve.Results: Population was formed of 1098 patients (mean age 65 ± 15 years; 47% female). VC was present in 31% of the overall population. Compared with subjects without VC, VC patients were older (60 ± 14 vs 75 ± 9; P < .0001), had more hypertension (40% vs 57%; P = .0005), diabetes (11% vs 18%; P = .002), coronary artery disease (22% vs 38%; P = .04), and chronic kidney disease (4% vs 8%; P = .007). Furthermore, VC patients had lower ejection fraction (55 ± 14 vs 53 ± 25; P < .0001), worse diastolic function (E/e' 8.5 ± 4.6 vs 13.0 ± 7.1; P < .0001) and higher pulmonary artery pressure (29 ± 9 vs 37 ± 12; P < .0001). The association between VC and EF was not independent of etiology (p for VC 0.13), whereas the association with E/e' and PASP was independent in a full multivariate model (P < .0001 and P = .0002, respectively). Conclusion:Heart valve calcification patients were characterized by a worse functional and hemodynamic profile compared to patients with normal valve. The association between VC and diastolic function and PASP were independent in comprehensive multivariate models.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Ta B L Ementioning

confidence: 99%

Heart valve calcification and cardiac hemodynamics

Rossi

Barbieri²,

Benfari

et al. 2021

Echocardiography

View full text Add to dashboard Cite

show abstract

“…atherosclerosis is the result of cholesterol and lipid deposition on the arterial wall, often related to calcification, which is formed by the deposition of inorganic calcium on the arterial wall. Thus, the upregulation of PDK4 increased osteogenic markers and enhanced vascular calcification without significant effects on bone formation (46). This indicated that PDK4 may be a new target for the treatment of vascular calcification (47,48).…”

Section: Discussionmentioning

confidence: 93%

Circulating mRNA and microRNA profiling analysis in patients with ischemic stroke

Sun

Dong

et al. 2020

Mol Med Rep

View full text Add to dashboard Cite

To provide insight into molecular diagnosis and individualized treatment of ischemic stroke (iS), several available datasets in iS were analyzed to identify the differentially expressed genes and micrornas (mirnas). Series matrix files from GSE22255 and GSE16561 (mRNA profiles), a well as GSE110993 (miRNA profile) were downloaded from the Gene Expression Omnibus database. System-level clustering was performed with GeneCluster 3.0 software, and gene annotation and pathway enrichment were performed with gene ontology analysis and database for annotation, Visualization and integrated discovery software. For a protein-protein interaction (PPI) network, Biological General Repository for interaction datasets and intact interaction information were integrated to determine the interaction of differentially expressed genes. The selected mirna candidates were imported into the TargetScan, mirdB and mirecords databases for the prediction of target genes. The present study identified 128 upregulated and 231 downregulated genes in female stroke patients, and 604 upregulated and 337 downregulated genes in male stroke patients compared with sex-and age-matched controls. The construction of a PPi network demonstrated that male stroke patients exhibited YWHAE, CUL3 and JUN as network center nodes, and in female patients CYLD, FOS and PIK3R1 interactions were the strongest. notably, these interactions are mainly involved in immune inflammatory response, apoptosis and other biological pathways, such as blood coagulation. Female and male upregulated genes were cross-validated with another set of Illumina HumanRef-8 v3.0 expression beadchip (GSE16561). Functional item association networks, gene function networks and transcriptional regulatory networks were successfully constructed, and the relationships between mirnas and target genes were successfully predicted. The present study identified a number of transcription factors, including DEFA1, PDK4, SDPR, TCN1 and MMP9, and miRNAs, including miRNA (miR)-21, miR-143/145, miR-125-5p and miR-122, which may serve important roles in the development of cerebral stroke and may be important molecular indicators for the treatment of iS.

show abstract

“…[6][7][8][9] On the other hand, some patients might have FMR without significant LV dilation, as reported in those with aortic stenosis, [13][14][15][16] suggesting that atherosclerosis-related risk factors may hinder compensatory mitral leaflet elongation by affecting leaflet degeneration and size. 17) In a previous study, 11) we found that some atherosclerosis-related risk factors were associated with mitral leaflet size and coaptation. We hypothesized that the cardio-ankle vascular index (CAVI), which is widely used for assessing atherosclerosis comprehensively, 18,19) may be associated with MV leaflet size.…”

mentioning

confidence: 78%

Mitral Valvular Coaptation-Zone Area Is Associated with the Severity of Atherosclerosis Assessed by Cardio-Ankle Vascular Index

Kawata

Nakao

et al. 2021

Int. Heart J.

View full text Add to dashboard Cite

Preservation of the mitral valve (MV) size is essential for valve function, and a reduced MV coaptationzone area increases the risk of developing functional mitral regurgitation (FMR). We aimed to determine if the MV leaflet and coaptation-zone areas were associated with the severity of atherosclerosis assessed by cardioankle vascular index (CAVI) in patients with normal left ventricle (LV) systolic function and size by real-time 3 D echocardiography (RT3DE).We performed RT3DE analysis in 66 patients with normal LV size and ejection fraction who underwent 2 D echocardiography and CAVI. MV coaptation-zone areas were measured by custom 3D software and indexed by body surface area (BSA). The associations of clinical factors and mean CAVI with MV leaflet and coaptation-zone areas were evaluated by univariable and multivariable linear regression analyses.On univariable analysis, MV leaflet area/BSA was significantly associated with age (r = −0.335, P = 0.0069

show abstract

Relationship of Aortic Wall Distensibility to Mitral and Aortic Valve Calcification: The Multi-Ethnic Study of Atherosclerosis

Cited by 7 publications

References 35 publications

Heart valve calcification and cardiac hemodynamics

Heart valve calcification and cardiac hemodynamics

Circulating mRNA and microRNA profiling analysis in patients with ischemic stroke

Mitral Valvular Coaptation-Zone Area Is Associated with the Severity of Atherosclerosis Assessed by Cardio-Ankle Vascular Index

Contact Info

Product

Resources

About