Relationship of Age and Biomedical Risk Factors to Progression of Coronary Artery Disease*

Abrahams, Joel; Nash, David T.; Gensini, Goffredo G.; Arno, Thomas

doi:10.1111/j.1532-5415.1978.tb02397.x

Cited by 3 publications

(2 citation statements)

References 14 publications

(10 reference statements)

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“…Our results also match with a research conducted by Veeranna et al He concluded that diabetes is an important determinant of IHD and its severity (Veeranna et al, 2010). Diabetes is also recognized as a factor responsible for progression of disease (Abrahams et al, 1978;Rajan and Prabhakaran, 2017). Glucose intolerance and insulin resistance or even impaired fasting levels still are responsible IHD development and progression (Konstantinou et al, 2010;Leon and Maddox, 2015).…”

Section: Discussionsupporting

confidence: 92%

Modifiable Risk Factors and Coronary Artery Disease Severity: Insights From a Case-Control Analysis

JAVAID,

ALI,

RAZZAQ

et al. 2023

Biol Clin Sci Res J

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Atherosclerotic coronary disease stands as a leading cause of both mortality and morbidity globally. The well-documented risk factors for coronary artery disease (CAD) include abnormal lipid levels, obesity, smoking, high blood pressure, and diabetes. The established association between these cardiovascular risk factors and ischemic heart disease is widely recognized. However, the correlation between risk factors for ischemic heart disease and the severity of CAD on coronary angiography remains less explored, with varying findings across studies. Our research involved a total of 200 patients aged 30 to 70 years, comprising 100 cases diagnosed with severe CAD and 100 controls with insignificant CAD. Factors contributing to CAD, such as smoking, high sugar levels, high blood pressure, lipid profiles, family history of CAD, and obesity, were assessed in all patients. Statistical analysis, employing the chi-square test, was conducted, and a significant association was considered when the odds ratio value exceeded 1. The mean age in our study population was 51.01 ± 7.76 years, with 159 (79.50%) being male. Among the patients, 99 (49.50%) were obese, 90 (45.0%) were diabetic, 94 (47.0%) were hypertensive, 77 (38.5%) were smokers, 53 (26.5%) had a positive family history, and 17 (8.5%) were dyslipidemic. In evaluating the association of cardiovascular risk factors with CAD severity, smoking (odds ratio 1.73, p-value 0.04), hypertension (odds ratio 1.6, p-value 0.05), diabetes (odds ratio 1.6, p-value 0.05), and obesity (odds ratio 1.98, p-value 0.016) emerged as independent factors significantly linked to the severity of CAD. Our findings underscore the independent roles of smoking, hypertension, diabetes, and obesity as risk factors contributing to the severity of ischemic heart disease.

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Section: Discussionsupporting

confidence: 92%

Modifiable Risk Factors and Coronary Artery Disease Severity: Insights From a Case-Control Analysis

JAVAID,

ALI,

RAZZAQ

et al. 2023

Biol Clin Sci Res J

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“…Prior studies of angiographic progression of CAD using serial quantitative angiography to define predictors of severity or progression of disease burden have also consistently identified diabetes as an independent predictor of disease progression. [27][28][29] Among these, the study by Abrahams and colleagues 27 is closest to our results, reporting that in 176 patients (age range, 27-66 years), diabetes mellitus was related to disease progression in older patients.…”

Section: Impact Of Diabetes and Lipids On Angiographic Obstructive Camentioning

confidence: 54%

Traditional Cardiovascular Risk Factors and Severity of Angiographic Coronary Artery Disease in the Elderly

Veeranna

Pradhan

Niraj

et al. 2009

Preventive Cardiology

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Over 80% of annual coronary heart disease mortality occurs in the elderly, a rapidly expanding subset of the population. The authors retrospectively examined the relationship between traditional cardiovascular risk factors and atherosclerotic coronary artery disease burden in a cohort of 631 elderly patients undergoing angiography. Age and male sex but not hypertension or dyslipidemia were predictors of presence of obstructive coronary artery disease (Duke score 2). Only diabetes mellitus emerged as an independent predictor of obstructive coronary artery disease burden. Smoking was found to be predictive of left main coronary artery disease. In summary, severity of angiographic disease in the elderly as assessed by Duke Myocardial Jeopardy scoring appears to correlate poorly with prevalence of established traditional cardiovascular risk factors. Prev Cardiol. 2010;13:135–140.©2009 Wiley Periodicals, Inc.

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Distribution of coronary artery disease severity and risk factors in Afro-Caribbeans

Larifla

Armand

Vélayoudom-Céphise

et al. 2014

Archives of Cardiovascular Diseases

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Relationship of Age and Biomedical Risk Factors to Progression of Coronary Artery Disease*

Cited by 3 publications

References 14 publications

Modifiable Risk Factors and Coronary Artery Disease Severity: Insights From a Case-Control Analysis

Modifiable Risk Factors and Coronary Artery Disease Severity: Insights From a Case-Control Analysis

Traditional Cardiovascular Risk Factors and Severity of Angiographic Coronary Artery Disease in the Elderly

Distribution of coronary artery disease severity and risk factors in Afro-Caribbeans

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