Relationship of Adipokines and Proinflammatory Cytokines Among Asian Indians With Obesity and Youth Onset Type 2 Diabetes

Gokulakrishnan, Kuppan; Amutha, Anandakumar; Ranjani, Harish; Bibin, Subramanian Y.; Balakumar, Mahalingam; Pandey, Gautam Kumar; Anjana, Ranjit Mohan; Ali, Mohammed K.; Narayan, K.M. Venkat; Mohan, Viswanathan

doi:10.4158/ep15741.or

Cited by 14 publications

(7 citation statements)

References 38 publications

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“…The associations of leptin levels with insulin resistance and diabetes are overall inconsistent as the positive, inverse, and null associations have been reported previously [ 15 , 26 , 33 ]. Our study revealed no statistically significant association between serum leptin and insulin resistance in both multiple linear and logistic regression analyses, a finding also observed in a nested case-control study in an Indian population [ 25 ].…”

Section: Discussionmentioning

confidence: 82%

Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population

Zhao

Jin

et al. 2017

PLoS ONE

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Although experimental studies have shown that adiponectin and leptin modulate glucose tolerance and insulin resistance, it remains unclear whether these adipocytokines exert similar effects in general human populations. We evaluated the associations of serum adiponectin and leptin with β-cell function and insulin resistance in a population with low obesity prevalence. A cross-sectional study of 783 rural residents, aged 25–74 years, recruited in Ningxia, China was conducted during 2008–2012. β-cell function and insulin resistance were estimated using the Homeostasis Model Assessment. Serum adiponectin and leptin were measured with ELISA. Serum adiponectin concentrations (mean ± SD) were highest in subjects with normal glucose tolerance (36.65 ± 61.13 μg/ml), intermediate in those with impaired fasting glucose (25.92 ± 34.48 μg/ml), and lowest in those with diabetes (15.08 ± 12.14 μg/ml) (p = 0.001). A similar pattern of differences was found for β-cell function, whereas opposite results were observed for insulin resistance and blood glucose. After adjustment for confounders including metabolic syndrome components, serum adiponectin (μg/ml) was inversely associated with β-cell function (%β) [β (95% CI): -7.57 (-12.33, -2.81)] and insulin resistance (100/%S) [β (95% CI): -0.21 (-0.33, -0.09)]. A significant inverse association also existed between serum leptin and β-cell function, but serum leptin was not significantly associated with insulin resistance. The present study suggests that adiponectin and leptin play a role in the development of insulin resistance and diabetes independent of metabolic syndrome.

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Section: Discussionmentioning

confidence: 82%

Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population

Zhao

Jin

et al. 2017

PLoS ONE

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“…The proinflammatory cytokines/chemokines, including IL-1β, IL-6, TNF-α, adipokines and leptin, are important for the initiation and development of MDs (21). The present study investigated whether ST modulates the proinflammatory cytokines, IL-6 and TNF-α, and confirmed the cytokine releasing levels in mouse and human macrophage cell lines.…”

Section: Discussionmentioning

confidence: 99%

Traditional medicine, Sobokchukeo-Tang, modulates the inflammatory response in adipocytes and macrophages

Lee¹,

Shim²,

Lee³

et al. 2016

Molecular Medicine Reports

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Sobokchukeo-Tang (ST) is a well-known formula that is used for treating primary dysmenorrhea caused by blood stasis syndrome (BSS) in Korea and China. The current study investigated the anti-inflammatory and anti-adipogenesis effects of ST on adipocytes and macrophages. The anti-inflammatory efficacy of ST was evaluated in RAW 264.7 cells and differentiated THP-1 cells. To induce inflammation, the cells were treated with lipopolysaccharide (LPS; 1 µg/ml). Following the induction of inflammation, the levels of proinflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the cell supernatant were detected using enzyme-linked immunosorbent assay. 3T3-L1 preadipocytes differentiated into adipocytes in response to insulin, isobutyl-1-methylxanthine and dexamethasone (MDI). To confirm the anti-adipogenesis efficacy of ST, we investigated Oil Red O staining was performed, triglyceride (TG) and leptin secretion were measured, and the protein expression of lipid metabolism-associated factors was determined. ST significantly inhibited TNF-α and IL-6 production in the LPS-treated RAW 264.7 cells compared with LPS stimulation alone. In addition, the concentrations of IL-6 and TNF-α were significantly inhibited by ST in LPS-treated THP-1 cells. Lipid accumulation was reduced by ST, similarly to the positive control treatment, SB203580. In the ST-treated group, the TG and leptin concentrations were inhibited by up to 50 and 83%, respectively, compared with MDI induction only. The ST-treated group reduced the protein expression of peroxisome proliferator-activated receptor-γ and CCAAT/enhancer-binding protein α compared with MDI induction only. The results of the present study demonstrated that ST exerts anti-inflammatory effects on LPS-treated mouse and human macrophage cell lines. ST inhibited adipogenesis in MDI-induced 3T3-L1 adipocytes, as indicated by the significant reduction in TG and leptin concentrations without cytotoxicity. Thus, ST may be useful as a therapeutic agent for preventing lipid-associated diseases, including obesity and atherosclerosis.

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“…In the DM state, insulin activity is reduced, resulting in decreased insulinstimulated glucose uptake. Simultaneously, abnormal metabolism of fuel nutrients [3], disordered activities of antioxidant enzymes [4] and increased inflammation [5] lead to a pronounced oxidative stress, which is characterized by increased malondialdehyde (MDA) level and decreased activities of antioxidant enzymes such as superoxide dismutase (SOD). In the current circumstances, a search for an antidiabetic herbal product with fewer side effects has gained considerable importance in the medical field [6].…”

Section: Introductionmentioning

confidence: 99%

Daidzin decreases blood glucose and lipid in streptozotocin-induced diabetic mice

Tian¹,

Liu²,

Liu³

et al. 2016

Trop. J. Pharm Res

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Relationship of Adipokines and Proinflammatory Cytokines Among Asian Indians With Obesity and Youth Onset Type 2 Diabetes

Cited by 14 publications

References 38 publications

Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population

Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population

Traditional medicine, Sobokchukeo-Tang, modulates the inflammatory response in adipocytes and macrophages

Daidzin decreases blood glucose and lipid in streptozotocin-induced diabetic mice

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