Relationship of abdominal adiposity and dyslipemic status in women with a common mutation in the lipoprotein lipase gene

Sentı́, Mariano; Bosch, Mela; Aubó, Clara; Elosúa, Roberto; Masiá, Rafel; Marrugat, Jaume

doi:10.1016/s0021-9150(99)00355-x

Cited by 27 publications

(24 citation statements)

References 29 publications

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“…Intra-abdominal visceral fat accumulation has been shown to affect LPL mass and activity either directly or via insulin resistance, thereby impairing the hydrolysis of TGs ( 24,25 ). Similarly, earlier studies demonstrated an interaction of the LPL -Hin dIII genotype with abdominal obesity on TG levels ( 41,42 ) and hypothesized that the presence of central obesity exacerbates the alterations in LPL activity caused by genetic variation, thus preventing the possible compensatory effects that may occur in nonobese individuals ( 42 ). Our identifi cation of a SNP-by-waist circumference interaction suggests that future studies should analyze genetic associations in different strata of anthropometric, life style, and other environmental factors.…”

Section: Discussionmentioning

confidence: 94%

Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels

Marvelle

et al. 2013

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 94%

Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels

Marvelle

et al. 2013

Journal of Lipid Research

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“…Although only few studies investigated the interactions between LPL gene polymorphisms and obesity, S447X and HindIII were the mostly reported polymorphisms. [8][9][10][37][38][39] The presence of HindIII polymorphism was reported to be strongly associated with hypertriglyceridemia in obese subjects. [37][38][39] However, results about the interaction of S447X polymorphism and obesity were not consistent but even contrary.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10][37][38][39] The presence of HindIII polymorphism was reported to be strongly associated with hypertriglyceridemia in obese subjects. [37][38][39] However, results about the interaction of S447X polymorphism and obesity were not consistent but even contrary. [8][9][10] Garenc et al 8 showed that the relation between X447 allele and TG only exists in obese subjects (BMI X30), but not in normal-weight subjects (BMI o25).…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein lipase gene S447X polymorphism modulates the relation between central obesity and serum lipids, a twin study

Huang

Zhan

et al. 2006

Int J Obes

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Objective: To investigate the impact of lipoprotein lipase (LPL) gene S447X polymorphism on the relation between central obesity and lipid levels. Design: A total of 961 adult twin pairs were included from the program of Chinese Twin Registry, between 2001 and 2002. Central obesity was defined as waist circumference X90 cm for male and X80 cm for female. Two statistical methods were performed to test the modification effect of S447X polymorphism of LPL gene on the relation between central obesity and lipid levels: one was Generalized Estimating Equation (GEE) models for all twin pairs and the other was co-twin matched case-control analysis in 82 central obesity discordant monozygotic twin pairs. Results: In GEE models for all twins, central obesity was significantly associated with serum lipids except for high-density lipoprotein (HDL), while X447 allele had favorable effects on the levels of triglyceride (TG), HDL and TG to HDL ratio (TG/HDL). The interactions of S447X polymorphism and central obesity were statistically significant for TG/HDL and HDL. In central obesity discordant monozygotic twin pairs, central obesity was significantly related with 26.2% increase of TG and 27.2% increase of TG/HDL in S/S447 genotype, while in 447X allele carrier, central obesity was significantly related with 13.7% increase of HDL. Conclusion: These results suggest that LPL gene S447X polymorphism modifies the relation between central obesity and serum lipids, which also stresses the importance of reducing waist circumference to improve serum lipids for people with central obesity, especially those with S/S447 genotype.

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“…BMI is influenced by various factors, including the effect of body build 16,19,23,24 . Meanwhile waist circumference is able to provide an estimate of abdominal fat, which in turn is correlated with the amount of intra-abdominal adipose tissue 4,16,25,26 . Weight changes are also known to relate to age; individuals who gain more than 10% weight from the age of 20 until middle age significantly increase their odds of developing arterial hypertension, dyslipidemia, and hyperinsulinemia 11,27 .…”

Section: Introductionmentioning

confidence: 99%

All-cause mortality among Japanese-Brazilians according to nutritional characteristics

2007

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The aim of this study was to verify the association between nutritional variables and mortality in a Japanese-Brazilian cohort. In 1993, 647 subjects were interviewed with food frequency questionnaires and scheduled for physical procedures (weight, height, blood pressure) and biochemical tests (oral glucose tolerance test). Student's t test was used to compare the mean values of target variables between living and deceased subjects. Mortality rate and hazard ratios were obtained (crude and adjusted) according to the nutritional variables. Overall mortality rates were 21.4 and 11.7/1,000 person-years for males and females, respectively. Smoking, diabetes, sedentary lifestyle, hypertension, higher mean age, high blood pressure, high blood glucose, and higher percent weight gain and rate of weight gain were observed in the history of deceased subjects. After adjusting for control variables, an increase was observed in mortality among individuals with lower carbohydrate and cholesterol intake. The results suggest that mortality risk factors like age, chronic diseases, sedentary lifestyle, smoking, and inadequate diet must also be acting in the Japanese-Brazilian population.

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Relationship of abdominal adiposity and dyslipemic status in women with a common mutation in the lipoprotein lipase gene

Cited by 27 publications

References 29 publications

Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels

Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels

Lipoprotein lipase gene S447X polymorphism modulates the relation between central obesity and serum lipids, a twin study

All-cause mortality among Japanese-Brazilians according to nutritional characteristics

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