Relationship of 2D:4D finger ratio with androgen receptor CAG and GGN repeat polymorphism

Zhang, Chuan; Deng, Jiehui; Pei, Liguo; Guo, Mingxiao; Zhu, Honglin; Qu, Lei; Jia, Fei; Hong, Lei; Huo, Zhenghao

doi:10.1002/ajhb.22347

Cited by 26 publications

(23 citation statements)

References 57 publications

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“…In accordance with the data in China 18,29, we found that men showed significantly smaller 2D:4D ratios than women in right and left hands. The ROCs analysis showed that the optimal cutoff point of digit ratio for CAD discrimination in male was 0.9505 in both hands with sensitivity 0f 57.8% and specificity of 68% in right hand, and 50.8% and 58.7% in left hand.…”

Section: Discussionsupporting

confidence: 91%

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

Wu¹,

Yang²,

Chai³

et al. 2013

Int. J. Med. Sci.

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Background: The association between index finger to ring finger length ratio (2D:4D) and cardiac disorders has been reported, however it has not been discussed in terms of coronary artery disease (CAD). We investigated whether 2D:4D could be used as a marker for predisposition to CAD as assessed by coronary angiography in Chinese men and women.Methods: This study included 1764 persons divided into 4 groups, 441 cases with CAD and 441 persons without CAD as control in each sex of the same age. Finger lengths were measured twice for both hands using electronic calipers. Student t test was used to detect the difference of 2D:4D among groups. The receiver operator characteristic curves (ROCs) were used to detect the diagnostic effect of 2D:4D for CAD.Results: There were no significant differences in age among the four groups. A significant difference of 2D:4D ratios between right and left hand were observed only in men in both control and CAD groups. On the right hand in the control group and on both hands in the CAD group, the 2D:4D ratios were higher in women than in men (all, P < 0.001). In men with CAD, mean 2D:4D was higher than mean 2D:4D in control men (right hand 0.962±0.042:0.927±0.038; left hand 0.950±0.044:0.934±0.048; both hands, P < 0.001), but this was not observed in women. No relationship was found between 2D:4D and age (all, P >0.05). The area under the curve of right hand 2D:4D in male was 0.72 (95% CI 0.683-0.753, p<0.001), while it was 0.602 (95% CI 0.565-0.639, p<0.001) in left hand.Conclusions: The present study showed an association between high 2D:4D ratio and CAD in both hands in men. There were no significant differences in mean 2D:4D between women with CAD and controls.

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Section: Discussionsupporting

confidence: 91%

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

Wu¹,

Yang²,

Chai³

et al. 2013

Int. J. Med. Sci.

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“…Genes reported to show an allelic association with 2D : 4D tend to show a failure to replicate. The initial report of an effect of a polymorphism in the androgen receptor gene has not been replicated in larger sample sizes (Hurd et al, 2011;Loehlin et al, 2012;Zhang et al, 2013). A SNP in LIN28B identified in a genome-wide association study by Medland et al (2010) did not replicate with statistical significance in a following study (Lawrance-Owen et al, 2013).…”

Section: Discussionmentioning

confidence: 92%

Inbreeding is associated with lower 2D: 4D digit ratio

Özener

Hurd

Duyar

2013

American J Hum Biol

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“…As females (but not males) have two AR gene copies, either the shorter allele, the longer allele, or the bi-allelic mean can be used. One report (28) reported all three analyses (which led to very similar results), and I used the result for the bi-allelic mean in the present analysis. For two other reports that involved females (29, 30) it remained unclear on which of the three measures their analysis was based.…”

Section: Methodsmentioning

confidence: 87%

No Evidence that 2D:4D is Related to the Number of CAG Repeats in the Androgen Receptor Gene

Hönekopp

2013

Front. Endocrinol.

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The length ratio of the second to the fourth digit (2D:4D) is a putative marker of prenatal testosterone (T) effects. The number of CAG repeats (CAGn) in the AR gene is negatively correlated with T sensitivity in vitro. Results regarding the relationship between 2D:4D and CAGn are mixed but have featured prominently in arguments for and against the validity of 2D:4D. Here, I present random-effects meta-analyses on 14 relevant samples with altogether 1904 subjects. Results were homogeneous across studies. Even liberal estimates (upper limit of the 95% CI) were close to zero and therefore suggested no substantial relationship of CAGn with either right-hand 2D:4D, left-hand 2D:4D, or the difference between the two. However, closer analysis of the effects of CAGn on T dependent gene activation in vitro and of relationships between CAGn and T dependent phenotypic characteristics suggest that normal variability of CAGn has mostly no, very small, or inconsistent effects. Therefore, the lack of a clear association between CAGn and 2D:4D has no negative implications for the latter’s validity as a marker of prenatal T effects.

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Relationship of 2D:4D finger ratio with androgen receptor CAG and GGN repeat polymorphism

Abstract: In this study, we first found that the left hand 2D:4D ratio was longer than that of the right hand in both males and females. However, we found that both CAG and GGN alleles were not associated with the left hand, right hand, right minus left-hand or mean hand 2D:4D ratios.

Cited by 26 publications

References 57 publications

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

Inbreeding is associated with lower 2D: 4D digit ratio

No Evidence that 2D:4D is Related to the Number of CAG Repeats in the Androgen Receptor Gene

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