Relationship Between Zinc, Selenium, and Magnesium Status and Markers of Metabolically Healthy and Unhealthy Obesity Phenotypes

Cruz, Kyria Jayanne Clímaco; de Oliveira, Ana Raquel Soares; Fontenelle, Larissa Cristina; Morais, Jennifer Beatriz Silva; de Sousa Melo, Stéfany Rodrigues; dos Santos, Loanne Rocha; de Sousa, Thayanne Gabryelle Visgueira; de Freitas, Suelem Torres; Henriques, Gilberto Simeone; Bordin, Silvana; Maia, Carla Soraya Costa; de Oliveira, Francisco Erasmo; Costa, Carlos Henrique Nery; de Matos Neto, Emídio Marques; do Nascimento Marreiro, Dilina

doi:10.1007/s12011-023-03938-z

Cited by 3 publications

(1 citation statement)

References 65 publications

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“…Li et al ( 20 ) proved that a high level of selenium intake (82.54 μg/day) is one of the main factors for maintaining the normal physical function and longevity of the older adults in Bama Yao County. Several studies have shown that selenium deficiency increases the risk of metabolic disorders, such as dyslipidemia, abnormal glucose metabolism, and thyroid hormone dysfunction ( 21 ), through oxidative stress and abnormal activation of the PI3K/Akt signaling pathway ( 22 ). Moreover, Yildirim et al ( 23 ) showed that selenium can prevent oxidative stress-related damage in acrylamide-induced testicular toxicity in rats.…”

Section: Introductionmentioning

confidence: 99%

Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults

Zhang,

Meng,

et al. 2024

Front. Nutr.

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ObjectiveSelenium is an essential micronutrient and a type of dietary antioxidant. This study aimed to investigate the associations of dietary selenium intake with the risk of human chronic disease [cardiovascular disease (CVD), diabetes mellitus (DM), and cancer] and mortality among US general adults.MethodsThe dietary and demographic data in this study were collected from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. Death outcomes were determined by associating with the National Death Index (NDI) records as of December 31, 2019. Logistic regression analyses were used to investigate the relationship of selenium intake with the risk of CVD, DM, and cancer. The effect of dietary selenium on all-cause and disease-specific mortality was estimated with restricted cubic spline (RCS) curves based on the univariate and multivariate Cox proportional hazard models.ResultsAmong the 25,801 participants, dietary selenium intake was divided into quintiles (Q1–Q5). After covariate adjustment, the results showed that the participants with higher quintiles (Q4 and Q5) of selenium intake tended to have a low risk of CVD (OR = 0.97, 95% CI: 0.96, 0.99; OR = 0.98, 95% CI: 0.97, 1.00, respectively). Moreover, the RCS curves showed a significant nonlinear association between selenium intake and the risk of all-cause (with a HR of 0.82, 95% CI: 0.68, 0.99) and DM-specific mortality (with the lowest HR of 0.30; 95% CI, 0.12–0.75). Furthermore, we conducted a subgroup analysis and found a negative correlation between the highest quartile of selenium intake and all-cause mortality among participants aged 50 and above (HR = 0.75, 95% CI: 0.60–0.93, p = 0.009).ConclusionOur results indicated that a moderate dietary selenium supplement decreased the risk of CVD and displayed a nonlinear trend in association with the risk of all-cause and DM-specific mortality among US adults. In addition, we found that participants aged 50 and older may benefit from higher selenium intake. However, these findings still need to be confirmed through further mechanism exploration.

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Section: Introductionmentioning

confidence: 99%

Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults

Zhang,

Meng,

et al. 2024

Front. Nutr.

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Magnesium, selenium and zinc deficiency compromises antioxidant defense in women with obesity

de Oliveira,

Cruz,

Morais

et al. 2024

Biometals

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Dietary Intakes of Copper and Selenium in Association with Bone Mineral Density

Pasco,

Anderson,

Williams

et al. 2024

Nutrients

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The important trace elements, copper and selenium, have diverse effects on human health. As well as other important roles in living tissues, these trace elements are toxic at high levels but are key constituents of various enzymes and proteins essential for maintaining physiological health. However, links between dietary intakes of these elements, particularly copper, and bone mineral density (BMD) in humans remain uncertain. This study aimed to investigate whether dietary intakes of copper and selenium are associated with BMD in women. Dietary intakes of copper and selenium were assessed for 575 women in the Geelong Osteoporosis Study, using a detailed semi-quantitative food frequency questionnaire in conjunction with nutrition composition databases. Participants taking oral multivitamin preparations were excluded from analyses; 522 participants (ages 20–88 y) met the eligibility criteria. BMD at multiple skeletal sites was measured by dual energy X-ray absorptiometry (Lunar DPX-L). Separate multivariable regression models were developed to identify associations between copper and selenium intakes and BMD, after adjustments for age, anthropometry, other dietary factors, medication use, and lifestyle factors. Median (interquartile range) daily intake for copper was 1.5 mg (1.2–1.9) and for selenium, 72 μg (57–90). Low intakes (lowest tertile versus pooled upper tertiles) of copper and selenium were consistently associated with lower BMD at multiple skeletal sites. Fully adjusted models identified small but statistically significant differences in BMD, ranging from 1.8% to 4.0% for low copper intakes and 1.4% to 4.0% for low selenium intakes. Low dietary intakes of copper and selenium were both independently associated with lower BMD, at least in this sample of women. The results contribute to the evidence base for informing dietary recommendations for these trace elements with respect to their contributions to optimal bone health.

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Relationship Between Zinc, Selenium, and Magnesium Status and Markers of Metabolically Healthy and Unhealthy Obesity Phenotypes

Cited by 3 publications

References 65 publications

Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults

Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults

Magnesium, selenium and zinc deficiency compromises antioxidant defense in women with obesity

Dietary Intakes of Copper and Selenium in Association with Bone Mineral Density

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