Relationship between zinc levels and plasma leptin in hemodialysis patients

Aranha, Luciana Nicolau; Lobo, Julie Calixto; Stockler‐Pinto, Milena Barcza; Leal, Viviane de Oliveira; Torres, João Paulo Machado

doi:10.1016/j.jtemb.2012.02.007

Cited by 15 publications

(8 citation statements)

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“…This higher concentration of leptin in females agrees with previous research, 18 and similar to Aranha et al, who observed that low plasma zinc levels were negatively associated with high leptin levels in HD patients. 6 Impairment of glomerular filtration in patients with renal insufficiency may lead to leptin-level elevation, which may cause loss of appetite and protein-energy malnutrition in patients with renal insufficiency. 7 Although not all patients with CKD have elevated serum leptin levels as reported in some studies, a significant elevation is noted when such levels are adequately corrected for age and body-fat mass.…”

Section: Discussionmentioning

confidence: 99%

“…6 Patients with chronic renal failure have a high level of serum leptin due to decreased renal clearance; 7 also, leptin is thought to be related to malnutrition, changes in body composition, and chronic inflammation in HD patients. 8 The relationship between zinc and leptin has been previously investigated in HD patients, 6 but there have been no studies investigating the effect of zinc supplementation in children under HD. Therefore, the aim of this work was to determine the effect of zinc supplementation on serum zinc and leptin levels and body mass index (BMI) in pediatric HD patients.…”

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confidence: 99%

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Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients

Elshazly¹,

Ibrahim²,

El-Mashad³

et al. 2015

IJNRD

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Introduction Zinc is an essential trace element for human nutrition, and its deficiency is associated with anorexia, poor food efficiency, growth retardation, and impaired neurological and immune systems. The zinc-deficiency rate is particularly high in many disease states, such as with end-stage renal disease patients undertaking hemodialysis. The aim of this study was to determine the effect of zinc supplementation on body mass index (BMI) and serum levels of zinc and leptin in pediatric hemodialysis patients. Patients and methods This was a prospective clinical trial study in which 60 hemodialysis patients were randomly divided into two groups: group I received 50–100 mg zinc sulfate (equivalent to 11–22 mg elemental zinc) according to age, sex, and nutritional status of the child; and group II received placebo (cornstarch) twice daily for 90 days. Anthropometric measurements were taken, and serum zinc and leptin levels were determined by colorimetric test with 5-Br-3′-phosphoadenosine-5′-phosphosulfate and enzyme-linked immunosorbent assay, respectively, at days 0 and 90 of the study. Results Zinc supplementation resulted in a significant increase in mean serum zinc level and BMI. Serum leptin decreased significantly after supplementation in children under hemodialysis. A significant negative correlation was observed between serum zinc and leptin levels as a result of zinc supplementation. Conclusion There was an increase in serum zinc level and BMI and decreased serum leptin after zinc supplementation in children under hemodialysis.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients

Elshazly¹,

Ibrahim²,

El-Mashad³

et al. 2015

IJNRD

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“…We previously showed that increased plasma Cu/Zn ratios was associated with decreased plasma albumin and hemoglobin levels (well-known markers of nutritional status), although both albumin and hemoglobin concentrations were influenced by numerous factors 10. Zn deficiency has been associated with diminished appetite and hyperleptinemia 36. Malnutrition in HD patients may result from low plasma Zn levels, in which case Zn supplementation will be needed to prevent progressive malnutrition 37.…”

Section: Discussionmentioning

confidence: 99%

Effects of Zinc Supplementation on Plasma Copper/Zinc Ratios, Oxidative Stress, and Immunological Status in Hemodialysis Patients

Guo¹,

Wang²

2013

Int. J. Med. Sci.

103

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Background: Patients undergoing hemodialysis (HD) have low plasma levels of zinc (Zn), high plasma levels of copper (Cu), and exhibit increased oxidative stress, inflammation, and immune abnormalities. We evaluated the effects of Zn supplementation on abnormal plasma Cu/Zn ratios and clinical outcomes in HD patients.Design and Methods: Patients on long-term HD with lower than normal plasma concentrations of Zn (< 80 mg/dL) were randomized to receive daily oral Zn supplements (n = 40) or no supplements (n = 25) for eight weeks. Age- and sex-matched healthy individuals served as a control group (n = 38). A number of clinical parameters were measured before and after the supplementation period.Results: Compared with healthy subjects, patients had significantly elevated plasma Cu concentrations and Cu/Zn ratios, as well as higher levels of oxidative stress and pro-inflammatory cytokines. Patients who received Zn supplements for eight weeks had higher plasma concentrations of Zn and lower concentrations of Cu, along with reduced Cu/Zn ratios, oxidative stress status, and inflammatory responses compared to patients who did not receive Zn. Patients receiving Zn also showed significantly higher percentages of CD4 and CD19 lymphocytes, and elevated CD4/CD8 ratios.Conclusions: Zn supplementation ameliorates abnormally high plasma Cu/Zn ratios and may reduce oxidative stress, improve inflammatory status, and maintain immune function in patients undergoing long-term HD.

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“…Disturbances in Zn balance have been linked directly to a number of biological disorders. Tissue Zn mass fractions, hereafter simply referred to as Zn ‘concentrations’, are commonly measured to investigate where and how Zn metabolism varies and whether new early diagnostic tools may be developed to combat diseases associated with such variations [2, 5–15]. …”

Section: Introductionmentioning

confidence: 99%

High Precision Zinc Stable Isotope Measurement of Certified Biological Reference Materials Using the Double Spike Technique and Multiple Collector-ICP-MS

et al. 2017

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Biological reference materials with well-characterised stable isotope compositions are lacking in the field of ‘isotope biochemistry’, which seeks to understand bodily processes that rely on essential metals by determining metal stable isotope ratios. Here, we present Zn stable isotope data for six biological reference materials with certified trace metal concentrations: fish muscle, bovine muscle, pig kidney, human hair, human blood serum and human urine. Replicate analyses of multiple aliquots of each material achieved reproducibilities (2sd) of 0.04–0.13‰ for δ66/64Zn (which denotes the deviation of the 66Zn/64Zn ratio of a sample from a pure Zn reference material in parts per 1000). This implies only very minor isotopic heterogeneities within the samples, rendering them suitable as quality control materials for Zn isotope analyses. This endorsement is reinforced by (i) the close agreement of our Zn isotope data for two of the samples (bovine muscle and human blood serum) to previously published results for different batches of the same material and (ii) the similarity of the isotopic data for the samples (δ66/64Zn ≈ –0.8 to 0.0‰) to previously published Zn isotope results for similar biological materials. Further tests revealed that the applied Zn separation procedure is sufficiently effective to enable accurate data acquisition even at low mass resolving power (M/ΔM ≈ 400), as measurements and analyses conducted at much higher mass resolution (M/ΔM ≈ 8500) delivered essentially identical results.Electronic supplementary materialThe online version of this article (doi:10.1007/s00216-017-0240-y) contains supplementary material, which is available to authorized users.

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Relationship between zinc levels and plasma leptin in hemodialysis patients

Cited by 15 publications

References 50 publications

Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients

Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients

Effects of Zinc Supplementation on Plasma Copper/Zinc Ratios, Oxidative Stress, and Immunological Status in Hemodialysis Patients

High Precision Zinc Stable Isotope Measurement of Certified Biological Reference Materials Using the Double Spike Technique and Multiple Collector-ICP-MS

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