Relationship between work rate and oxygen uptake in mitochondrial myopathy during ramp-incremental exercise

Gimenes, Ana Cristina; Neder, J. Alberto; Corso, S. Dal; Nogueira, C.R.; Nápolis, Lara Maris; Mello, Marco Túlio de; Bulle, A.S.; Nery, Luíz Eduardo

doi:10.1590/s0100-879x2011000400013

Cited by 18 publications

(27 citation statements)

References 14 publications

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“…Functional VO 2 gain represents an index of delivery and utilization of oxygen by the muscles during exercise . A reduced ability to increase VO 2 with work rate, again, indicates that there is an increased reliance on anaerobic glycolysis during exercise to meet the energy demands.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, unlike exercise capacity, the functional VO 2 gain (ΔVO 2 /ΔWR) is effort independent and represents an index of aerobic efficiency . Additionally, ΔVO 2 /ΔWR is a sensitive indicator of abnormal muscle oxygen delivery or utilization during exercise, and exhibits a proportional association with exercise capacity . A lower functional VO 2 gain has been reported in several patient populations and to our knowledge only three studies have compared patients with CF and controls which yield conflicting results.…”

Section: Introductionmentioning

confidence: 99%

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Oxygen uptake kinetics and exercise capacity in children with cystic fibrosis

Fielding

Brantley

Seigler

et al. 2015

Pediatric Pulmonology

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Exercise capacity, an objective measure of exercise intolerance, is known to predict quality of life and mortality in cystic fibrosis (CF). The mechanisms for exercise intolerance in patients with cystic fibrosis (CF), however, have yet to be fully elucidated. Accordingly, this study sought to investigate oxygen uptake kinetics and the impact of fat-free mass (FFM) on exercise capacity in young patients with CF. 16 young patients with CF (age 13 ± 4 years; 10 female) and 15 matched controls (age 14 ± 3 years; nine female) participated. Pulmonary function and a maximal exercise test on a cycle ergometer using the Godfrey protocol were performed. Exercise capacity (VO2 peak), VO2 response time (VO2 RT), and functional VO2 gain (ΔVO2 /ΔWR) were all determined. Lung function was the only demographic parameter significantly lower (P < 0.05) in CF compared to controls. Exercise capacity was lower in CF (P < 0.014) only when VO2 peak was normalized for FFM (43.5 ± 7.7 vs. 50.6 ± 7.4 ml/kg-FFM/min) or expressed as % predicted (70.1 ± 14.3 vs. 85.4 ± 16.0%). The VO2 RT was slower (36.1 ± 15.1 vs. 25.0 ± 12.4 sec; P = 0.03) and the ΔVO2 /ΔWR slope was lower (8.4 ± 3 ml/min/watt vs. 10.1 ± 1.4 ml/min/watt; P = 0.02) in patients compared to controls, respectively. In conclusion, a delayed VO2 response time coupled with the lower functional VO2 gain (ΔVO2 /ΔWR) suggest that young patients with CF have impairment in oxygen transport and oxygen utilization by the muscles. These data in addition to differences in VO2 peak normalized for FFM provide some insight that muscle mass and muscle metabolism contribute to exercise intolerance in CF.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxygen uptake kinetics and exercise capacity in children with cystic fibrosis

Fielding

Brantley

Seigler

et al. 2015

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

“…Gimenes et al [37] determined the response characteristics and functional correlates of the dynamic relationship between the rate (Ä) of oxygen consumption (VO 2 ) and the applied power output (work rate = WR) during ramp-incremental exercise in 14 patients with mitochondrial myopathy vs. 10 sedentary controls. They claim that a readily available, effort-independent index of aerobic dysfunction during dynamic exercise is typically reduced in patients with mitochondrial myopathy, being related to increased functional impairment and higher cardiopulmonary stress.…”

Section: Kk and Rocha E Silva M -Cardiology In Brazilian Scientific Joumentioning

confidence: 99%

Cardiology in Brazilian scientific journals: an overview

Patel

Silva

2012

Rev Bras Cir Cardiovasc

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Cardiology has been and is a very significant fraction of the Brazilian contribution to science. In older days, the most significant part of this work was directed to foreign periodicals, but the quasi-simultaneous emergence of SciELO and PUBMED has ordained a redirection of much of this work to Brazilian periodicals. We here survey some of this more recent contribution for the benefit of readers of Revista Brasileira de Cirurgia Cardiovascular. This is offered as an update. Articles on the general themes of Cardiology and Pneumology published by four ISI Indexed Brazilian journals not specializing in cardiology are re-visited, after a search through 10 journals. ResumoA Cardiologia foi, e continua sendo, responsável por uma fracção muito significativa da contribuição brasileira para a ciência. No passado, os trabalhos mais importantes eram direcionados para periódicos estrangeiros, mas o surgimento quase simultâneo do SciELO e PUBMED facilitou um redirecionamento de grande parte desses trabalhos a periódicos brasileiros. Neste artigo, examinamos algumas das contribuições mais recentes em benefício aos leitores da Revista Brasileira de Cirurgia Cardiovascular. Esta discussão é oferecida como uma atualização. Artigos sobre os temas gerais da cardiologia e pneumologia publicados por quatro revistas brasileiras indexadas no ISI -não especializadas em cardiologia -são revistos.RBCCV

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“…Gimenes et al (42) studied the oxygen uptake to work rate ratio in relation to various indicators of aerobic dysfunction during ramp incremental exercise in patients with mitochondrial myopathy and controls. The authors concluded that that ratio is a readily available, effort-independent index of aerobic dysfunction.…”

Section: Exercisementioning

confidence: 99%

Pesquisas em pneumologia recentemente publicadas em revistas brasileiras

Gomes

Higa

2012

J. bras. pneumol.

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We reviewed original articles in the field of pulmonary medicine that had been recently published in 12 Brazilian journals-general or specialty journals-excluding the Brazilian Journal of Pulmonology. All were journals indexed for the Institute for Scientific Information Web of Knowledge. The selection of articles was based on the "continuously variable rating" concept. We have organized the articles by category.Keywords: Pulmonary medicine; Medical oncology; Research; Infectious disease medicine. ResumoRevisamos estudos originais no campo da pneumologia que foram recentemente publicados em 12 publicações gerais ou de especialidades -que não o Jornal Brasileiro de Pneumologia -indexadas no Institute for Scientific Information Web of Knowledge. A seleção dos artigos foi baseada no conceito de continuously variable rating, e os artigos foram classificados em categorias.

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Relationship between work rate and oxygen uptake in mitochondrial myopathy during ramp-incremental exercise

Cited by 18 publications

References 14 publications

Oxygen uptake kinetics and exercise capacity in children with cystic fibrosis

Oxygen uptake kinetics and exercise capacity in children with cystic fibrosis

Cardiology in Brazilian scientific journals: an overview

Pesquisas em pneumologia recentemente publicadas em revistas brasileiras

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