Relationship between white matter glucose metabolism and fractional anisotropy in healthy and schizophrenia subjects

Mitelman, Serge A.; Buchsbaum, Monte S.; Christian, Bradley T.; Merrill, Brian; Adineh, Mehdi; DeCastro, Alex; Buchsbaum, Bradley R.; Lehrer, Douglas S.

doi:10.1016/j.pscychresns.2020.111060

Cited by 3 publications

(1 citation statement)

References 68 publications

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“…Compared to controls, SCZ patients were characterized by significantly higher metabolic rates in the corpus callosum, frontal, superior longitudinal, and temporal lobe white matter circuit, findings that have been partially replicated in more recent studies [ 96 ]. Moreover, white matter metabolism is inversely associated with fractional anisotropy in SCZ, suggesting that a decrease in the structural integrity of white matter results in an increase in indices of brain engagement [ 97 ]. Thus, observed functional inefficiency is a logical expression of unsurmountable structure brain deficits.…”

Section: Discussionmentioning

confidence: 99%

Inefficient white matter activity in Schizophrenia evoked during intra and inter-hemispheric communication

et al. 2022

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Intensive cognitive tasks induce inefficient regional and network responses in schizophrenia (SCZ). fMRI-based studies have naturally focused on gray matter, but appropriately titrated visuo-motor integration tasks reliably activate inter- and intra-hemispheric white matter pathways. Such tasks can assess network inefficiency without demanding intensive cognitive effort. Here, we provide the first application of this framework to the study of white matter functional responses in SCZ. Event-related fMRI data were acquired from 28 patients (nine females, mean age 43.3, ±11.7) and 28 age- and gender-comparable controls (nine females, mean age 42.1 ± 10.1), using the Poffenberger paradigm, a rapid visual detection task used to induce intra- (ipsi-lateral visual and motor cortex) or inter-hemispheric (contra-lateral visual and motor cortex) transfer. fMRI data were pre- and post-processed to reliably isolate activations in white matter, using probabilistic tractography-based white matter tracts. For intra- and inter-hemispheric transfer conditions, SCZ evinced hyper-activations in longitudinal and transverse white matter tracts, with hyper-activation in sub-regions of the corpus callosum primarily observed during inter-hemispheric transfer. Evidence for the functional inefficiency of white matter was observed in conjunction with small (~50 ms) but significant increases in response times. Functional inefficiencies in SCZ are (1) observable in white matter, with the degree of inefficiency contextually related to task-conditions, and (2) are evoked by simple detection tasks without intense cognitive processing. These cumulative results while expanding our understanding of this dys-connection syndrome, also extend the search of biomarkers beyond the traditional realm of fMRI studies of gray matter.

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Section: Discussionmentioning

confidence: 99%

Inefficient white matter activity in Schizophrenia evoked during intra and inter-hemispheric communication

et al. 2022

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Four-modality imaging of unmedicated subjects with schizophrenia: 18F-fluorodeoxyglucose and 18F-fallypride PET, diffusion tensor imaging, and MRI

Buchsbaum

Mitelman

Christian

et al. 2022

Psychiatry Research: Neuroimaging

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Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia

Gou

Chen

et al. 2023

Schizophrenia Bulletin

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Background and Hypothesis Low-grade neural and peripheral inflammation are among the proposed pathophysiological mechanisms of schizophrenia. White matter impairment is one of the more consistent findings in schizophrenia but the underlying mechanism remains obscure. Many cerebral white matter components are sensitive to neuroinflammatory conditions that can result in demyelination, altered oligodendrocyte differentiation, and other changes. We tested the hypothesis that altered immune-inflammatory response system (IRS) and compensatory immune-regulatory reflex system (IRS/CIRS) dynamics are associated with reduced white matter integrity in patients with schizophrenia. Study Design Patients with schizophrenia (SCZ, 70M/50F, age = 40.76 ± 13.10) and healthy controls (HCs, 38M/27F, age = 37.48 ± 12.31) underwent neuroimaging and plasma collection. A panel of cytokines were assessed using enzyme-linked immunosorbent assay. White matter integrity was measured by fractional anisotropy (FA) from diffusion tensor imaging using a 3-T Prisma MRI scanner. The cytokines were used to generate 3 composite scores: IRS, CIRS, and IRS/CIRS ratio. Study Results The IRS/CIRS ratio in SCZ was significantly higher than that in HCs (P = .009). SCZ had a significantly lower whole-brain white matter average FA (P < .001), and genu of corpus callosum (GCC) was the most affected white matter tract and its FA was significantly associated with IRS/CIRS (r = 0.29, P = .002). FA of GCC was negatively associated with negative symptom scores in SCZ (r = −0.23, P = .016). There was no mediation effect taking FA of GCC as mediator, for that IRS/CIRS was not associated with negative symptom score significantly (P = .217) in SCZ. Conclusions Elevated IRS/CIRS might partly account for the severity of negative symptoms through targeting the integrity of GCC.

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Relationship between white matter glucose metabolism and fractional anisotropy in healthy and schizophrenia subjects

Cited by 3 publications

References 68 publications

Inefficient white matter activity in Schizophrenia evoked during intra and inter-hemispheric communication

Inefficient white matter activity in Schizophrenia evoked during intra and inter-hemispheric communication

Four-modality imaging of unmedicated subjects with schizophrenia: 18F-fluorodeoxyglucose and 18F-fallypride PET, diffusion tensor imaging, and MRI

Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia

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