Relationship Between Weight Change in Young Adulthood and the Risk of NIDDM: The Sotetsu Study

Sakurai, Yoshinori; Teruya, Koji; Shimada, Naoki; Wakabayashi, Kazuo; Umeda, Takashi; Honjo, Satoshi; Todoroki, Isao; Tanaka, Hiroyuki; Muto, Takashi; Sakurai, Masaru; Nakamura, Kou

doi:10.2337/diacare.20.6.978

Cited by 28 publications

(23 citation statements)

References 12 publications

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“…Subjects' mean baseline BMI was 31.3 kg/m2, and these people gained an average of 0.1 kg/y (1.0 kg total) over the first 10 years of the study. Two thirds of the sample were women, and the crude incidence of diabetes was 13% (table 1).…”

Section: Resultsmentioning

confidence: 99%

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Relation of weight gain and weight loss on subsequent diabetes risk in overweight adults

Resnick

Valsania²,

Halter³

et al. 2000

Journal of Epidemiology &Amp; Community Health

283

180

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Study objective-To determine whether long term weight gain and weight loss are associated with subsequent risk of type 2 diabetes in overweight, non-diabetic adults. Design-Prospective cohort. Baseline overweight was defined as BMI>27.3 for women and BMI>27.8 for men. Annual weight change (kg/year) over 10 years was calculated using measured weight at subjects' baseline and first follow up examinations. In the 10 years after measurement of weight change, incident cases of diabetes were ascertained by self report, hospital discharge records, and death certificates. Setting-Community. Participants-1929 overweight, non-diabetic adults. Main results-Incident diabetes was ascertained in 251 subjects. Age adjusted cumulative incidence increased from 9.6% for BMI<29 to 26.2% for BMI>37. Annual weight change over 10 years was higher in subjects who become diabetic compared with those who did not for all BMI<35. Relative to overweight people with stable weight, each kg of weight gained annually over 10 years was associated with a 49% increase in risk of developing diabetes in the subsequent 10 years. Each kg of weight lost annually over 10 years was associated with a 33% lower risk of diabetes in the subsequent 10 years. Conclusions-Weight gain was associated with substantially increased risk of diabetes among overweight adults, and even modest weight loss was associated with significantly reduced diabetes risk. Minor weight reductions may have major beneficial eVects on subsequent diabetes risk in overweight adults at high risk of developing diabetes.

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Section: Resultsmentioning

confidence: 99%

“…Accordingly, two models were defined (table 3). Model I included age, age2 and BMI. The quadratic term for age indicates a non-linear association between age and diabetes risk.…”

Section: Resultsmentioning

confidence: 99%

Relation of weight gain and weight loss on subsequent diabetes risk in overweight adults

Resnick

Valsania²,

Halter³

et al. 2000

Journal of Epidemiology &Amp; Community Health

283

180

View full text Add to dashboard Cite

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“…In the present study, we examined biomarkers related to obesity that may be relevant for the development of Weight change between ages 25 and 40 years W e i g h t c h a n g e b e t w e e n a g e s 4 0 a n d 5 5 y e a r s W e i g h t c h a n g e b e t w e e n a g e s 4 0 a n d chronic diseases, including markers of insulin sensitivity, glucose metabolism, inflammation, dyslipidaemia and hepatic fat accumulation. Several studies have suggested an association between an increase in BMI in adulthood and unfavourable lipid profiles [16][17][18][19] and onset of type 2 diabetes [20][21][22][23][24][25][26][27][28][29][30] as well as cardiovascular diseases after adjustment for attained weight at entry to the study [31][32][33][34][35][36][37]. However, although the association between obesity and risk of various chronic diseases is well documented, there is only limited information about the question of whether the time of onset of obesity or changes in BMI throughout life affects metabolism or disease risk beyond adiposity.…”

Section: Discussionmentioning

confidence: 99%

Association of changes in body mass index during earlier adulthood and later adulthood with circulating obesity biomarker concentrations in middle-aged men and women

et al. 2011

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Aims/hypothesis The objective of our study was to investigate whether changes in BMI during earlier adulthood are more strongly associated with levels of circulating obesity biomarkers in middle age than are BMI changes during later adulthood. Methods The study included 1,612 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. The associations of BMI changes based on recalled BMI for the age ranges 25-40 years (earlier adulthood) and 40-55 years (later adulthood) with later biomarker levels were compared using a linear model, adjusted for BMI at age 25 years and conventional risk factors. Results BMI changes during both time periods as well as BMI at age 25 years were significantly associated with circulating levels of adiponectin, γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), high-sensitivity Creactive protein (hs-CRP) and HDL-cholesterol (HDL-C) in both sexes, and of HbA 1c in women. However, BMI gain for the age range 25-40 years was significantly more strongly associated with unfavourable levels of adiponectin, hs-CRP, HDL-C and HbA 1c in men and women, and of GGT and ALT in men (p difference <0.05) than BMI gain for the age range 40-55 years. The percentage change in biomarker levels per unit gain in BMI for the age range 25-40 years ranged from 0.81% (HbA 1c ) to 9.80% (hs-CRP) in men, and from 0.75% (HbA 1c ) to 14.7% (hs-CRP) in women, whereas for the age range 40-55 years, values ranged from −0.15% to 4.82% in men and from 0.25% to 7.06% in women. Conclusions/interpretationThe results support the hypothesis that an increase in BMI in earlier adulthood is more strongly associated with unfavourable circulating levels of obesity biomarkers later in life than is an increase in BMI in later adulthood.

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“…[459][460][461][462][463][464][465] Relative to people who are overweight and do not gain weight, a gain of one kg of weight per year for 10 years in adults who are overweight is associated with a 49% increased risk of developing diabetes in the next 10 years. 464 Weight loss is associated with a substantially reduced risk of diabetes in the general population.…”

Section: Weight Gain and Weight Lossmentioning

confidence: 99%

Absolute risk of cardiovascular disease events, and blood pressure‐ and lipid‐lowering therapy in Australia

Banks

Crouch

Korda

et al. 2016

Medical Journal of Australia

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Objective: To quantify absolute cardiovascular disease (CVD) risk and treatment in Australian adults. Design, participants: Cross‐sectional representative study of 9564 people aged 18 years or more who had participated in the 2011–12 Australian National Health Measures Survey (response rate for those aged 45–74 years: 46.5%). Main outcome measures: Prior CVD was ascertained and 5‐year absolute risk of a primary CVD event calculated (using the Australian National Vascular Disease Prevention Alliance algorithm; categories: low [< 10%], moderate [10–15%], and high [> 15%] risk) on the basis of data on medical history, risk factors and medications, derived from interviews, physical measurements, and blood and urine samples. Results: Absolute CVD risk increased with age and was higher among men than women. Overall, 19.9% (95% CI, 18.5–21.3%) of Australians aged 45–74 years had a high absolute risk of a future CVD event (an estimated 1 445 000 people): 8.7% (95% CI, 7.8–9.6%) had prior CVD (estimated 634 000 people) and 11.2% (95% CI, 10.2–12.2%) had high primary CVD risk (estimated 811 000 people). A further 8.6% (95% CI, 7.4–9.8%, estimated 625 000) were at moderate primary CVD risk. Among those with prior CVD, 44.2% (95% CI, 36.8–51.6%) were receiving blood pressure‐ and lipid‐lowering medications, 35.4% (95% CI, 27.8–43.0%) were receiving only one of these, and 20.4% (95% CI, 13.9–26.9%) were receiving neither. Corresponding figures for high primary CVD risk were 24.3% (95% CI, 18.3–30.3%); 28.7% (95% CI, 22.7–34.7%); and 47.1% (95% CI, 39.9–54.3%). Conclusions: About one‐fifth of the Australian population aged 45–74 years (about 1.4 million individuals) were estimated to have a high absolute risk of a future CVD event. Most (estimated 970 000) were not receiving currently recommended combination blood pressure‐ and lipid‐lowering therapy, indicating substantial potential for health gains by increasing routine assessment and treatment according to absolute CVD risk.

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Relationship Between Weight Change in Young Adulthood and the Risk of NIDDM: The Sotetsu Study

Abstract: Extreme weight gain between 20 and 25 years of age is a significant predictor of NIDDM, independent of current age, BMI at 20 years of age, and weight change within other age strata.

Cited by 28 publications

References 12 publications

Relation of weight gain and weight loss on subsequent diabetes risk in overweight adults

Relation of weight gain and weight loss on subsequent diabetes risk in overweight adults

Association of changes in body mass index during earlier adulthood and later adulthood with circulating obesity biomarker concentrations in middle-aged men and women

Absolute risk of cardiovascular disease events, and blood pressure‐ and lipid‐lowering therapy in Australia

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