Relationship between vitamin D status in pregnancy and the risk for preeclampsia: A nested case-control study

Benachi, Alexandra; Baptiste, Amandine; Taieb, Julien; Tsatsaris, Vassilis; Gadrey, Jean; Senat, M.‐V.; Haidar, Hazar; Jani, Jacques; Guizani, Meriem; Jouannic, Jean‐Marie; Haguet, Marie Clotilde; Winer, Norbert; Masson, Damien; Courbebaisse, Marie; Elie, Caroline; Souberbielle, Jean‐Claude

doi:10.1016/j.clnu.2019.02.015

Cited by 27 publications

(22 citation statements)

References 24 publications

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“…A study made in Est Iran identified that preeclampsia women (n=80) had lower levels of 25(OH)D when compared to healthy control women (n=80; p=0,01). This total difference of 25(OH)D remained significant even after the probable confounders were controlled (OR)=4,79, confidence interval (CI)=1,45-9,87, p=0,01 [26].…”

Section: Discussionmentioning

confidence: 86%

Blood Dosage of Vitamin D in Pregnant Women and Association with Preeclampsia and Fetal Low Weight

Ba¹,

Cac²,

Hsr³

et al. 2020

Asp Biomed Clin Case Rep

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Objective: The present study aimed to evaluate the vitamin D blood dosage during the three gestational trimesters, while identifying the frequency of pregnant women in the normal range, the variance in the three periods and evaluate the association between vitamin D and the obstetric complications such as preeclampsia, diabetes, and weight of the newborn. Methods: This is a longitudinal study with pregnant and non-pregnant women, from which there was collected data of anamneses, physical exam, obstetric info, as well as milk consumption habits, sunscreen and sun exposure, and also the vitamin D blood dosage. Results: There were 91 Pregnant Women studied, from whom the comparison between the vitamin D dosages identified the absence of gestation as a protective factor for VDD; the tendency for lower levels of supplementations when the workplace is in an external environment; the association between vitamin D and pre-eclampsia in the first trimester. Conclusion: The most relevant consequences from VDD were pre-eclampsia in the first trimester, the absence of gestation as a protective factor for VDD, and the need to consider the workplace before supplementation.

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Section: Discussionmentioning

confidence: 86%

Blood Dosage of Vitamin D in Pregnant Women and Association with Preeclampsia and Fetal Low Weight

Ba¹,

Cac²,

Hsr³

et al. 2020

Asp Biomed Clin Case Rep

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“…This change was examined in a previous analysis using the FEPED cohort. The increase of 25-OHD levels was estimated to 6.3 ng/mL (SD = 12.6) and 8.5 (SD = 11.5) in women with pre-eclampsia and in those with no pre-eclampsia [28]. In our study, we found that almost half of women had vitamin D deficiency (<20 ng/mL) in their first trimester of pregnancy; our study adds to limited research showing that vitamin D deficiency is highly prevalent among pregnant women [25,26,45,46].…”

Section: Discussionmentioning

confidence: 95%

“…Our study has several strengths. We used data from a large multicentre prospective cohort explicitly designed to investigate the association between maternal vitamin D concentrations and perinatal outcomes [27,28]. All pregnant women had a blood draw between 10 and 14 weeks of gestation, as opposed to other studies that used wide gestational age limits for the assessment of 25-ODH concentrations [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…The FEPED study is an observational prospective cohort conducted from April 2012 through July 2014 in five French and one Belgium maternity units [27,28]. The primary aim of this study was to assess the prevalence of vitamin D deficiency over the course of pregnancy and the association between vitamin D concentrations and preeclampsia [28]. Eligible women were aged over 18 years old with a singleton pregnancy between 10 and 14 weeks of gestational age at enrolment.…”

Section: Methodsmentioning

confidence: 99%

“…(Figure 1) indicates pale skin and type VI very dark skin. Women were subsequently grouped into those with lighter skin (skin type I through IV) and those with darker skin (skin type from V to VI), in line with previous investigations [26,28]. After delivery, sociodemographic and clinical data were abstracted from medical records by personnel trained for the study.…”

Section: Study Populationmentioning

confidence: 99%

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First Trimester Maternal Vitamin D Status and Risks of Preterm Birth and Small-For-Gestational Age

et al. 2019

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Maternal 25-hydroxyvitamin D (25-OHD) deficiency during pregnancy may increase the risk of preterm and small-for-gestational age (SGA) birth, but studies report conflicting results. We used a multicenter prospective cohort of 2813 pregnant women assessed for 25-OHD levels in the first trimester of pregnancy to investigate the association between maternal 25-OHD concentrations and risks of preterm birth (<37 weeks) and SGA (birthweight <10th percentile). Odds ratios were adjusted (aOR) for potential cofounders overall and among women with light and dark skin separately, based on the Fitzpatrick scale. 25-OHD concentrations were <20 ng/mL for 45.1% of the cohort. A total of 6.7% of women had a preterm birth. The aOR for preterm birth associated with the 1st quartile of 25-OHD concentrations compared to the 4th quartile was 1.53 (95% confidence interval (CI): 0.97–2.43). In stratified analyses, an association was observed for women with darker skin (aOR = 2.89 (95% CI: 1.02–8.18)), and no association with lighter skin. A total of 11.9% of births were SGA and there was no association overall or by skin color. Our results do not provide support for an association between maternal first trimester 25-OHD deficiency and risk of preterm or SGA birth overall; the association with preterm birth risk among women with darker skin requires further investigation.

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The relationship among vitamin D, TLR4 pathway and preeclampsia

Souza

Pisani

2020

Mol Biol Rep

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Relationship between vitamin D status in pregnancy and the risk for preeclampsia: A nested case-control study

Cited by 27 publications

References 24 publications

Blood Dosage of Vitamin D in Pregnant Women and Association with Preeclampsia and Fetal Low Weight

Blood Dosage of Vitamin D in Pregnant Women and Association with Preeclampsia and Fetal Low Weight

First Trimester Maternal Vitamin D Status and Risks of Preterm Birth and Small-For-Gestational Age

The relationship among vitamin D, TLR4 pathway and preeclampsia

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