Relationship between vitamin D deficiency and both gestational and postpartum depression

Ribamar, Amanda; Almeida, Bianca; Soares, Andressa Miozzo; Peniche, Beatriz; Jesus, Patrí­cia Britto Ribeiro de; Cruz, Sabrina; Ramalho, Adriana Ribeiro

doi:10.20960/nh.02953

Cited by 8 publications

(13 citation statements)

References 39 publications

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“…Although there is biological plausibility for a role of 25OHD in the development of depression, the current literature base has been unable to demonstrate this. Our mixed, inconclusive results align with other reviews of vitamin D and depression during or outside of the perinatal period [ 9 , 23 , 24 , 25 , 26 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ]. All called for further, high quality research to provide conclusive evidence, and several recommended that vitamin D supplementation only be considered for individuals with deficient 25OHD status [ 11 , 18 , 23 , 24 , 25 , 26 , 27 , 68 , 69 , 70 ].…”

Section: Discussionsupporting

confidence: 89%

A Systematic Review of Vitamin D during Pregnancy and Postnatally and Symptoms of Depression in the Antenatal and Postpartum Period from Randomized Controlled Trials and Observational Studies

et al. 2022

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Depression is a common mood disorder associated with childbirth and is hypothesized to be affected by low vitamin D. This systematic review identified two randomized controlled trials (RCT) of vitamin D supplementation for the treatment or prevention of depressive symptoms in the perinatal period, as well as 18 observational studies of vitamin D exposure and depression in the antenatal and postnatal periods. Both RCTs claimed an improvement in depressive symptoms in the vitamin D group, although the sample sizes were too small to draw firm conclusions. The case-control and cohort studies had mixed findings and were limited by study quality. There were inconsistent results within the few studies with a more robust methodology or within samples restricted to women likely to have depression. The current evidence is inconclusive due to the poor quality and heterogeneity of studies, likely contributing to the contradictory findings. Given there are already numerous RCTs of prenatal vitamin D supplementation, we recommend adding an appropriate measure of depression in the perinatal period to assist in resolving the uncertainty.

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Section: Discussionsupporting

confidence: 89%

A Systematic Review of Vitamin D during Pregnancy and Postnatally and Symptoms of Depression in the Antenatal and Postpartum Period from Randomized Controlled Trials and Observational Studies

et al. 2022

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“…[30] Many researchers have found that receptors of Vitamin D are primarily doled out throughout the brain of human, and its lack mutates neurotransmitters which are familiar to be included in of depression's symptoms. [12] Although the results of our study indicated a slight decrease in Vitamin D concentrations among the pregnant women who afterbirth affected by PPD; we found that the sera Vitamin D levels had no significant link between women with PPD and those with non-PPD (P = 0.6497), as shown in Table 1 [5,12,[31][32][33][34] they also found sera Vitamin D concentrations were significantly lower in depressed women than in the healthy subject. Similarly, the study Wang et al [35] did not record a considerable connect between depressive symptoms and low concentrations of Vitamin D through pregnancy.…”

Section: Discussionmentioning

confidence: 56%

Relationship between Sera Vitamin D, Calcium, and Magnesium Levels in Pregnant Women with and without Postpartum Depression

Mohammed

Saed

Jarallah

2022

Cihan U Erbil SCI J

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Postpartum depression (PPD) is a significant mental health case after childbirth, distinguished by behavioral changes and emotional disturbance. PPD is a significant public issue estimated to affect 10–15% of women worldwide. The study's objective was to investigate whether low sera concentrations of vitamin D, calcium, and magnesium during the third trimester of pregnancy are associated with PPD. The study population included eighty pregnant women between the ages of 25 to 35 years. They were divided into two groups (control and depressed group). Simple samples technique collecting was used for serum collecting from the two groups. When the blood samples were taken, vitamin D level was determined using an ELISA device. Calcium and magnesium were measured by using the spectrophotometric method. A health questionnaire structure was used for screening depression after birth. After measuring pregnancy serum concentrations of vitamin D of (40) pregnant control and (40) pregnant with PPD, we found that there was no significant relationship between vitamin D concentrations and risk of PPD (p= 0.6497). Statistical analysis indicated the significant differences (p= 0.0003) between sera calcium levels of the control group as compared with the depressed group. Significant differences (p= 0.0005) in magnesium levels between the two groups were observed. Our study detected that vitamin D concentrations in the serum of women during their last trimester of pregnancy had no statistical link with their risk of PPD. Whereas direct associated with calcium and magnesium deficiency in the third trimester of pregnancy and the incidence of PPD were reported.

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“…Also they showed vitamin D supplementation had proven to be a promising strategy for reducing the risk of depressive symptoms. 35 The Endocrine Society recommends routine vitamin D supplementation during pregnancy and lactation due to increased metabolic demand in the mother, but we tried to search Cochrane review where we did not find any recommendation for routine Vit D screening in pregnant women. 36 Having lots of controversies regarding Vit D screening, our study showed that Vit D deficiency is associated with PPD so it could be in routine program.…”

Section: Discussionmentioning

confidence: 99%

Association of Post-Partum Depression (PPD) with Anaemia and Vitamin D Deficiency

Nasreen

Mahjabeen

Shahreen

2023

J. Bangladesh Coll. Phys.

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Background: Postpartum depression (PPD) affects about 15% of mothers. It is a serious disorder that may affect physical and mental health of new mothers and newborns. Mothers suffering from anemia and vitamin D deficiency may be at increased risk of developing PPD. Aim: Our study aimed to detect the association of anaemia and Vit D deficiency with postpartum depression & also to look at association of other maternal and perinatal complications. Materials & methods: In this cross sectional observational study, pregnant women having anemia (Hb% <11gm/dl), were grouped as A (n=141), pregnant women having low Vit D were grouped as B (n=28), and pregnant women with normal Hb% and normal Vit D were grouped as grouped C (n=58). A & B were taken as cases and group C was taken as control in the study. Depression was evaluated by using Edinburg postnatal depression rating scale, P <0.05 was taken as statistically significant. Also secondary outcome like PPH, wound infection, Apgar score, preterm birth neonatal admission were noted down. Results: Depression was found significantly higher in both A= 60.3% and B =14.2%, than group C =0% (p<0.0001). Postpartum hemorrhage (PPH) and wound infection were found higher for group A (58% & 13%), Group B (28 &3%) respectively than control group C (5 &2%). Interestingly all women with VitD deficiency had postpartal haemorrhage (PPH). Regarding neonatal outcome, APGAR score was low in A (38%) and B (10.7%) in compare to control group C (0%). NICU Admission was seen higher in A=26% & B=10.7% than for C=0%. Incidence of Preterm birth (PTB) for A =25% & B= 2% were significantly higher than group C= 0%. No stillbirth was found in any group. Conclusion: Prevention, identification and treatment of anaemia and Vitamin D deficiency in pregnant women seem necessary, as they are strongly associated with postpartum depression and other complications. J Bangladesh Coll Phys Surg 2023; 41: 114-119

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Relationship between vitamin D deficiency and both gestational and postpartum depression

Cited by 8 publications

References 39 publications

A Systematic Review of Vitamin D during Pregnancy and Postnatally and Symptoms of Depression in the Antenatal and Postpartum Period from Randomized Controlled Trials and Observational Studies

A Systematic Review of Vitamin D during Pregnancy and Postnatally and Symptoms of Depression in the Antenatal and Postpartum Period from Randomized Controlled Trials and Observational Studies

Relationship between Sera Vitamin D, Calcium, and Magnesium Levels in Pregnant Women with and without Postpartum Depression

Association of Post-Partum Depression (PPD) with Anaemia and Vitamin D Deficiency

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