Relationship between Vitamin D and the development of atrial fibrillation after on-pump coronary artery bypass graft surgery

Abstract

SummaryBackground:Vitamin D deficiency is associated with many diverse cardiovascular disorders, such as hypertension, heart failure, stroke, coronary artery disease and atrial fibrillation. The relationship between Vitamin D and the development of atrial fibrillation after coronary artery bypass surgery (CABG) has not been studied. Therefore, we assessed the relationship between Vitamin D and the development of postoperative atrial fibrillation (POAF) after CABG.Methods:Medical records of consecutive patients who underwent CABG surgery were retrospectively reviewed for the development of atrial fibrillation in the postoperative period. Vitamin D, other biochemical parameters, and clinical and echocardiographic parameters were evaluated in all patients. The independent variables for the development of postoperative atrial fibrillation were defined and their predictive values were measured.Results:The study group consisted of 128 patients, of whom 41 (32%) developed POAF. Age, diabetes mellitus, chronic obstructive pulmonary disease, history of transient ischaemic attack/stroke, heart failure, left atrial diameter, platelet:largecell ratio, and creatinine, urea, uric acid, calcium and potassium levels were identified as important variables for the development of POAF. However, with logistic regression analysis, chronic obstructive pulmonary disease (OR: 28.737, 95% CI: 0.836–16.118, p < 0.001), heart failure (OR: 15.430, 95% CI: 0.989–7.649, p = 0.006), diabetes mellitus (OR: 11.486, 95% CI: 0.734–11.060, p = 0.001) and left atrial diameter (OR: 1.245, 95% CI: 0.086–6.431, p = 0.011) appeared as independent variables predicting the development of POAF.Conclusion:In our study, although there was a significant negative correlation between Vitamin D and left atrial diameter, Vitamin D level was not an independent predictor for POAF.

Effect of Plasma Level of Vitamin D on Postoperative Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Grafting

“…In one of these studies, Gode et al [16] reported that 25(OH) vitamin D level were significantly lower in the PoAF group (P=0.007). In two similar studies, investigators found that there was no relationship between lower 25(OH) vitamin D levels and AF [14,17] . In our study, 25(OH) vitamin D level were significantly lower in the PoAF(+) group (P=0.002).…”

“…In our study, in binary logistic regression analysis, age > 65 years was found to be an independent variable predicting the development of PoAF. Cerit et al [14] found that age was significantly associated with development of PoAF following CABG in univariate logistic regression analysis. In another study, Geçmen et al [15] showed that age was as an independent variable predicting the development of PoAF in both univariate and multivariate logistic regression analyses.…”

Newly developed post-operative atrial fibrillation is associated with an increased risk of late recurrence of atrial fibrillation in patients who underwent open heart surgery: Long-term follow up

“…A previously higher SYNTAX score [25] and HATCH score [26] were independent predictors for developing POAF after CABG. Vitamin D deficiency was evaluated to predict the development of POAF in patients receiving CABG, which showed insignificant factor [27]. Whether these parameters have predictive value in the development of late AF were not evaluated yet and further studies are necessary.…”

Is there a seasonal feature of new onset atrial fibrillation after coronary artery bypass graft surgery?

“…There are many publications in the literature on low vitamin D levels and postoperative AF 3,4 . In recent years, there are many publications in the literature regarding the relationship between vitamin D deficiency and postoperative AF development.…”