Relationship between Visual Dysfunction and Retinal Changes in Patients with Multiple Sclerosis

Satué, María; Rodrigo, María Jesús; Otı́n, Santos; Bambo, M; Fuertes, M. I.; Ara, J.R.; Martín, Javier Montero; Polo, Vicente; Larrosa, José M.; Júlvez, Luis Pablo; García‐Martín, Elena

doi:10.1371/journal.pone.0157293

Cited by 24 publications

(21 citation statements)

References 36 publications

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“…Our findings on the association between retinal atrophy and VA are consistent with previous studies although comparing outcomes is difficult due to methodological differences. Nevertheless, the majority of studies showed that thinning of both pRNFL and GCIPL is associated with VA, 15 – 17 , 34 , 35 whereas some only found significant associations with LCVA. 36 …”

Section: Discussionmentioning

confidence: 98%

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Retinal atrophy in relation to visual functioning and vision-related quality of life in patients with multiple sclerosis

et al. 2017

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Background:Inner retinal layer atrophy in patients with multiple sclerosis (MS) has been validated as a structural imaging biomarker for neurodegeneration.Objective:To determine how retinal layer thickness relates to high-contrast visual acuity (HCVA), low-contrast visual acuity (LCVA) and vision-related quality of life (QoL) and to investigate the effect of previous episodes on MS-associated optic neuritis (MSON).Methods:Spectral-domain optical coherence tomography (SD-OCT) was performed in 267 patients with MS. Images were segmented for the peripapillary retinal nerve fiber layer (pRNFL) and the macular ganglion cell inner plexiform layer (GCIPL). Ophthalmological evaluations included history of MSON, HCVA, LCVA, and vision-related QoL.Results:Independent of MSON, HCVA and LCVA were significantly associated with pRNFL and GCIPL thicknesses. Vision-related QoL was positively associated with pRNFL (β = 0.92, p = 0.06) and GCIPL (β = 0.93, p = 0.02) thicknesses. These associations were independent of MSON. Not only binocular but also monocular atrophy of the inner retinal layers was associated with lower vision-related QoL.Conclusion:This study showed that retinal atrophy has a significant impact on visual functioning in patients with MS. OCT may therefore provide useful insight to patients with visual dysfunction, and our findings support including OCT and vision-related QoL measures into optic neuritis treatment trials.

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Section: Discussionmentioning

confidence: 98%

“…Previous studies have investigated the relationship between peripapillary retinal nerve fiber layer (pRNFL) thickness and visual dysfunction 15 – 17 or general measures of QoL 18 in patients with MS. The assessment of general QoL in patients with MS is however strongly influenced by the mobility of the patient.…”

Section: Introductionmentioning

confidence: 99%

Retinal atrophy in relation to visual functioning and vision-related quality of life in patients with multiple sclerosis

et al. 2017

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“…During the last few years, several studies carried out on patients suffering from different neurodegenerative diseases such as sclerosis [9,30,31] have found reductions in the RNLF of the retina. However, to the best of our knowledge, our study is unique because no other studies have been carried out to date comparing the thickness of the different layers of the retina in patients with AUD.…”

Section: Correlation Between Retinal Thickness and Cognitive Impairmentmentioning

confidence: 99%

Retinal Nerve Fiber Layer in Patients with Alcohol Use Disorder

et al. 2019

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The objectives of the present study are to determine the effects of alcohol use on the retinal nerve fiber layer (RNFL) thickness and macular thickness of abstinent patients with alcohol use disorders (AUD) and to assess whether it correlates with alcohol consumption and/or cognitive impairment. This was a prospective, observational study that included 21 patients (42 eyes) and 21 controls (42 eyes). Patients met the criteria for early remission AUD at the moment of inclusion. We used optical coherence tomography to assess retinal thickness. Macular thickness in the group of AUD patients was lower in all quadrants (p < 0.05), with the exception of the peripheral and central. Regarding the nerve fiber layer in the macular and papilla areas, we found no significant differences. At the retina ganglion cell layer and in the nerve fiber of the macula, we found significant differences in all quadrants (p < 0.05), with the exception of the superior and superior nasal area, for the right eye. For the left eye, the only differences were found in the lower quadrant. Finally, when comparing the AUD patients to the controls, we found significant reductions in the ganglion cell layer of the macula in all quadrants in the former. There was a significant correlation between these findings and cognitive impairment (measured with the Test de Detección de Deterioro Cognitivo en Alcoholismo (TEDCA)), but not with alcohol consumption. Alcohol consumption is correlated with retinal harm and related cognitive decline.

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“…The examination of the visual pathway, as a part of the central nervous system, has been proven to be an effective starting point in addressing not only ophthalmologic 1,2,3,4,5 , but also neurologic 6,7,8,9,10,11,12,13,14,15,16 questions. In recent years, OCT and OKR have been identified as useful analytic, non-invasive tools to evaluate a large variety of retinopathies and retinal manifestations in various rodent models 17,18,19,20,21,22,23,24,25 .…”

Section: Introductionmentioning

confidence: 99%

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Dietrich

Hecker

Hilla

et al. 2019

JoVE

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Optical coherence tomography (OCT) is a fast, non-invasive, interferometric technique allowing high-resolution retinal imaging. It is an ideal tool for the investigation of processes of neurodegeneration, neuroprotection and neuro-repair involving the visual system, as these often correlate well with retinal changes. As a functional readout, visually evoked compensatory eye and head movements are commonly used in experimental models involving the visual function. Combining both techniques allows a quantitative in vivo investigation of structure and function, which can be used to investigate the pathological conditions or to evaluate the potential of novel therapeutics. A great benefit of the presented techniques is the possibility to perform longitudinal analyses allowing the investigation of dynamic processes, reducing variability and cuts down the number of animals needed for the experiments. The protocol described aims to provide a manual for acquisition and analysis of high quality retinal scans of mice and rats using a low cost customized holder with an option to deliver inhalational anesthesia. Additionally, the proposed guide is intended as an instructional manual for researchers using optokinetic response (OKR) analysis in rodents, which can be adapted to their specific needs and interests.

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Relationship between Visual Dysfunction and Retinal Changes in Patients with Multiple Sclerosis

Cited by 24 publications

References 36 publications

Retinal atrophy in relation to visual functioning and vision-related quality of life in patients with multiple sclerosis

Retinal atrophy in relation to visual functioning and vision-related quality of life in patients with multiple sclerosis

Retinal Nerve Fiber Layer in Patients with Alcohol Use Disorder

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

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