Relationship between Vision-Related Quality of Life and Central 10° of the Binocular Integrated Visual Field in Advanced Glaucoma

Abstract

To investigate the relationships between sensitivity loss in various subfields of the central 10° of the binocular integrated visual field (IVF) and vision-related quality of life (VRQoL) in 172 patients with advanced glaucoma. Using the Random Forest algorithm, which controls for inter-correlations among various subfields of the IVF, we analysed the relationships among the Rasch analysis-derived person ability index (RADPAI), age, best-corrected visual acuity (BCVA), mean total deviations (mTDs) of eight quadrant subfields in the IVF measured with the Humphrey Field Analyzer (HFA) 10-2 program (10-2 IVF), and mTDs of the upper/lower hemifields in the IVF measured with the HFA 24-2 program (24-2 IVF). Significant contributors to RADPAIs were as follows: the inner and outer lower-right quadrants of the 10-2 IVF contributed to the dining and total tasks; the lower-left quadrant of the 10-2 IVF contributed to the walking, going out and total tasks; the lower hemifield of the 24-2 IVF contributed to the walking, going out, dining, miscellaneous and total tasks; and BCVA contributed more to the letter, sentence, dressing and miscellaneous tasks than to others. The impact of damage in different 10-2 IVF subfields differed significantly across daily tasks in patients with advanced glaucoma.

The Relationship Between Macula Retinal Ganglion Cell Density and Visual Function in the Nonhuman Primate

“…This is supported by the relatively weak correspondence between standard visual field metrics and vision-related quality of life. 64 , 65 …”

“…This is supported by the relatively weak correspondence between standard visual field metrics and vision-related quality of life. 64,65 It is possible to improve quantification of visual function as there is strong correspondence between structure and function using smaller stimuli. Even at early stages of neuropathy, a reduction of visual thresholds can be quantified when the stimulus is smaller than the critical area.…”

Comparison of 10-2 and 24-2C Test Grids for Identifying Central Visual Field Defects in Glaucoma and Suspect Patients

“…5,6 Identification of central vision loss is important for disease staging and management, especially due to its impact on patient quality-of-life and activities of daily living. 7,8 Accurately describing central visual function in glaucoma is important for understanding an individual's ability to undertake essential tasks such as reading, near work and recognising distant objects for navigation and driving. [9][10][11] Preservation of central vision is an important component of glaucoma management.…”

Topical Review: Assessment of Binocular Sensory Processes in Low Vision

“…However, whether the more subtle binocular visual field defects detected with integrated visual field affect functionality and vision-related quality of life is of greater relevance, and there have been mixed results from this perspective, with some studies reporting superior correlations with integrated visual field 82 , 85 , 86 and others finding better correlations with Esterman. 77 , 87 Nevertheless, the integrated visual field has been used to identify patients with atypical performance on reach to grasp tasks including initiating movement and misestimation of object location, 47 as well as identifying areas of the binocular visual field affecting self-reported function in activities such as reading, dining, and walking in patients with glaucoma 88 , 89 (Fig. 2 ), and these may be beneficial to identify areas of potential difficulty based on individual patients' visual fields to target rehabilitative processes.…”

“… Schematic demonstrating locations within the central 60° most important for reading (top left), dining (top right), and walking and going out (bottom left) in patients with glaucoma calculated using the IVF, based on Murata et al 88 and Yamazaki et al 89 (shaded in red and blue, respectively). The smallest to largest concentric rings indicate 10, 24, and 30° from fixation, respectively.…”