Relationship between visceral fat accumulation and urinary albumin-creatinine ratio in middle-aged Japanese men

Tamba, Sachiko; Nakatsuji, Hideaki; Kishida, Ken; Noguchi, Midori; Ogawa, Takumi; Okauchi, Yukiyoshi; Nishizawa, Hitoshi; Imagawa, Akihisa; Nakamura, Tadashi; Matsuzawa, Yūji; Funahashi, Tohru; Shimomura, Iichiro

doi:10.1016/j.atherosclerosis.2010.02.037

Cited by 43 publications

(35 citation statements)

References 33 publications

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“…Hence, in subjects with normoalbuminuria, taking into account the finding that urinary adiponectin excretion rate is mildly increased or even decreased as mentioned earlier, serum adiponectin levels are expected to decrease with increasing UAE (increasing renal adiponectin clearance). Consistently, serum adiponectin levels have been reported to be negatively correlated with UAE mainly in subjects with normoalbuminuria and less consistently in patients with low-grade microalbuminuria (Tsioufis et al 2005, Sharma et al 2008, Barlovic et al 2009, Tamba et al 2010. Importantly, this relationship was reported in populations with preserved GFR, without the concomitant upregulation of circulating adiponectin due to reduced GFR.…”

Section: Serum Adiponectin Levels In Patients With Albuminuriasupporting

confidence: 59%

“…The negative relationship between circulating adiponectin and UAE in the context of normoalbuminuria or lowgrade microalbuminuria was consistently found in obese populations, while this association was inconsistently reported in nonobese subjects and when it did exist this association was too weak (Yano et al 2007, Barlovic et al 2010, Tamba et al 2010, Vasilescu & Ionescu-Tîrgovişte 2011. The underlying mechanism for these associations has not been clarified yet.…”

Section: The Role Of Adiponectin In Obesity-induced Albuminuriamentioning

confidence: 99%

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The role of adiponectin in renal physiology and development of albuminuria

Christou¹,

Kiortsis²

2014

Journal of Endocrinology

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Adiponectin is secreted by the adipose tissue and is downregulated in states of obesity and insulin resistance. There is a growing body of evidence indicating that adiponectin has renoprotective effects and protects against the development of albuminuria in rodent experiments. Adiponectin crossing the glomerular filtration barrier possibly inhibits inflammation, fibrosis and oxidative stress in kidneys through activation of AMP-activated protein kinase. Moreover, microalbuminuria is a well established early sign of progressive cardiovascular and renal disease, even in subjects with preserved glomerular filtration rate. Studies investigating the relationship between serum adiponectin levels and urinary albumin excretion rate (UAE) have yielded conflicting data and the mechanisms underlying the interplay between adiponectin and albuminuria remain to be elucidated. This article constitutes a critical review attempting to clarify any remaining confusion about this matter. Furthermore, this article examines the clinical significance of adiponectin-albuminuria interplay, suggesting that adiponectin is possibly involved in the development of albuminuria that is associated with obesity, diabetes and cardiovascular disease and may mediate, at least in part, the actions of medical treatments that influence UAE, such as angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers, thiazolidinediones, fenofibrate and diet. Further studies to investigate more thoroughly the renoprotective role of adiponectin in the human setting should be carefully planned, focusing on causality and the possible influence of adiponectin on the development of albuminuria in specific clinical settings.

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Section: Serum Adiponectin Levels In Patients With Albuminuriasupporting

confidence: 59%

Section: The Role Of Adiponectin In Obesity-induced Albuminuriamentioning

confidence: 99%

The role of adiponectin in renal physiology and development of albuminuria

Christou¹,

Kiortsis²

2014

Journal of Endocrinology

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“…Through "Hokenshido", the guided subjects recognized a problem in their own lifestyle and attempted to reduce visceral fat as a goal to maintain a healthy life. In our Amagasaki Visceral Fat Study (8)(9)(10)(11)(12)(13)(14)(15)(16)(17), we reported that the decrease in visceral fat was correlated with the decrease in the number of metabolic risk factors in the general male population (8).…”

Section: Discussionmentioning

confidence: 99%

“…chart on the way to develop atherosclerosis, was applied by the medical staff to prevent further development of lifestyle-related diseases and CVD for each subject. We reported previously that the decrease in visceral fat within one year correlated with the decrease in the number of metabolic risk factors (raised blood pressure, dyslipidemia and glucose intolerance) and increase in serum levels of adiponectin (8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Health Education "Hokenshido" Program Reduced Metabolic Syndrome in the Amagasaki Visceral Fat Study. Three-Year Follow-up Study of 3,174 Japanese Employees

et al. 2011

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Objective The aim of this study was to evaluate the effects of health checkup and the health education "Hokenshido" program based on the concept that visceral fat accumulation causes metabolic syndrome (MetS), leading to cardiovascular disease (CVD). Methods and SubjectsBased on the Japanese definition of metabolic syndrome, in the annual health checkup for general subjects, the measurement of waist circumference and use of "Where am I?" chart on the way to develop atherosclerosis were introduced. The study group comprised 3,174 Japanese employees .2%, 14.4%, p< 0.001) and females (3.0%, 2.2%, 1.9%, p=0.359), respectively. Among subjects with MetS at baseline, the number of subjects with MetS significantly decreased in males (508, 287, 247, p<0.0001) and females (22, 8, 6, p<0.0001), respectively. Mean waist loss was 1.6 cm in males (<0.0001) and 1.5 cm in females (<0.001). Among subjects with metabolic syndrome at baseline, the mean waist loss was 2.5 cm in males (<0.0001) and 3.9 cm in females (<0.05). Fatal atherosclerotic vascular events were not recorded in this study period. Conclusion Health check-up and the "Hokenshido" program reduced the prevalence of the MetS, which might lead to prevention of CVD.

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“…De fato, em seres humanos, o aumento do índice de massa corporal está associado à diminuição da função renal independentemente da presença de hipertensão arterial e diabetes. 23,24 São diversos os fatores que poderiam determinar a lesão glomerular nesse modelo experimental, em que associa-se obesidade neuroendócrina com hipertensão arterial. Trabalhos de Hall et al 21,22 propõem que a deposição de gordura visceral poderia determinar compressão da cápsula renal, determinando retenção hidrossalina por ativação do sistema renina angiotensina aldosterona, além do aumento da atividade adrenérgica.…”

Section: Medida Da Obesidade Visceralunclassified