2015
DOI: 10.1016/j.bjid.2015.01.004
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Relationship between viral load and behavioral measures of adherence to antiretroviral therapy in children living with human immunodeficiency virus in Latin America

Abstract: Few studies have examined antiretroviral therapy adherence in Latin American children. Standardized behavioral measures were applied to a large cohort of HIV-infected children in Brazil, Mexico, and Peru to assess adherence to prescribed antiretroviral therapy doses during the three days prior to study visits, assess timing of last missed dose, and evaluate the ability of the adherence measures to predict viral suppression. Time trends in adherence were modeled using a generalized estimating equations approach… Show more

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Cited by 17 publications
(20 citation statements)
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“…A multi-centre research conducted in three Latin American countries measured ART adherence levels and assessed the ability of the adherence measures to predict viral suppression in HIV-infected children. Many of the fully adherent children had detectable VLs, perhaps as a result of previous sub-therapeutic concentrations that led to ARV resistance and sub-optimal suppression of HIV replication while some of the children who were non-adherent had undetectable VLs [43]. ART adherence findings showed the association with VL in the study participants.…”
Section: Monitoring Of Hiv Drug Resistancementioning
confidence: 83%
See 1 more Smart Citation
“…A multi-centre research conducted in three Latin American countries measured ART adherence levels and assessed the ability of the adherence measures to predict viral suppression in HIV-infected children. Many of the fully adherent children had detectable VLs, perhaps as a result of previous sub-therapeutic concentrations that led to ARV resistance and sub-optimal suppression of HIV replication while some of the children who were non-adherent had undetectable VLs [43]. ART adherence findings showed the association with VL in the study participants.…”
Section: Monitoring Of Hiv Drug Resistancementioning
confidence: 83%
“…ART adherence findings showed the association with VL in the study participants. However, this association may not be sufficient to clearly identify non-adherence and those at risk of developing viral resistance [43].…”
Section: Monitoring Of Hiv Drug Resistancementioning
confidence: 99%
“…2) [60,61,63,[65][66][67][68][69][70][71][72]. The rates must be viewed with some reservation as methods and numbers differ, and there may be an overestimation using recall and pill counts.…”
Section: Adherence and Viral Load Suppressionmentioning
confidence: 99%
“…Las opciones terapéuticas en los niños son limitadas pues no todos los medicamentos tienen formulaciones pediátricas y existe el inconveniente de la transmisión de cepas resistentes de la madre al feto 33,34 . Los estudios de resistencia en población pediátrica son necesarios, tanto para aquellos niños tratados con falla a la terapia, como en aquellos que se comenzarán a tratar, para iniciar una terapia de primera línea altamente efectiva 33,34 .…”
Section: Niñosunclassified
“…Las opciones terapéuticas en los niños son limitadas pues no todos los medicamentos tienen formulaciones pediátricas y existe el inconveniente de la transmisión de cepas resistentes de la madre al feto 33,34 . Los estudios de resistencia en población pediátrica son necesarios, tanto para aquellos niños tratados con falla a la terapia, como en aquellos que se comenzarán a tratar, para iniciar una terapia de primera línea altamente efectiva 33,34 . Para realizar un estudio con el objetivo de conocer los mutantes virales y su asociación con los niveles de resistencias a los ARV, es necesario realizar un análisis a un mayor número de muestras, contando con los datos clínicos, terapéuticos y epidemiológicos de todos ellos.…”
Section: Niñosunclassified