Relationship between very early brain structure and neuromotor, neurological and neurobehavioral function in infants born &lt;31 weeks gestational age

George, Joanne M.; Fiori, Simona; Fripp, Jürgen; Pannek, Kerstin; Guzzetta, Andrea; David, Michael; Ware, Robert S.; Rose, Stephen; Colditz, Paul B.; Boyd, Roslyn N.

doi:10.1016/j.earlhumdev.2017.12.014

Cited by 33 publications

(28 citation statements)

References 37 publications

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“…( 78 ) Age-specific optimality scores allow comparisons with neurophysiologic and imaging findings, with good correspondence between HNNE scores and neuroimaging. ( 78 , 79 ) The Hammersmith Infant Neurological Examination (HINE), for infants aged 2–24 months demonstrates good correspondence between MRI findings and HINE scores in infants with NE. ( 80 ) Sequential use of the HNNE in the newborn period and the HINE through 2 years of age, offers a continuum for assessment of neurologic function and allows identification of early signs of cerebral palsy (CP) and other neurological disorders.…”

Section: Intermediate and Long-term Neurophysiology And Developmentmentioning

confidence: 99%

“…( 14 ) Future clinical trial designs could incorporate new paradigms to address common challenges, considering various phases of injury and recovery, and no longer a pseudo-normalization of 2-year test-scores (see Table 3 for a summary of recommendations). ( 8 , 10 , 56 – 60 , 63 , 64 , 71 , 73 , 74 , 15 , 75 , 77 – 79 , 81 – 84 , 98 , 102 , 17 , 103 – 111 , 27 , 30 , 32 , 35 , 47 , 55 )…”

Section: Perspectives From the Sprmentioning

confidence: 99%

“…Identification and classification of trial participants: Solutions to optimize the predictive value of the neurologic exam include performing consistently-timed, serial exams, standardization through extensive practice in other newborn populations, video recording of the exam, and use of standardized, scorable and predictive exams such as the HNNE. ( 77 – 79 ) A panel of multiple inflammatory and neuronal biomarkers may also advance the current landscape of NE clinical trials and individualize care by characterizing degree of initial injury, risk stratification, and acute assessment of treatment efficacy. For example, metabolomic profiling could characterize mechanisms of injury that differentiate mild from more severe NE and need for specific adjuvants.…”

Section: Perspectives From the Sprmentioning

confidence: 99%

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Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future

et al. 2020

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The next phase of clinical trials in neonatal encephalopathy (NE) focuses on hypothermia adjuvant therapies targeting alternative recovery mechanisms during the process of hypoxic brain injury. Identifying infants eligible for neuroprotective therapies begins with the clinical detection of brain injury and classification of severity. Combining a variety of biomarkers (serum, clinical exam, EEG, movement patterns) with innovative clinical trial design and analyses will help target infants with the most appropriate and timely treatments. The timing of magnetic resonance imaging (MRI) and MR spectroscopy after NE both assists in identifying the acute perinatal nature of the injury (days 3–7) and evaluates the full extent and evolution of the injury (days 10–21). Early, intermediate outcome of neuroprotective interventions may be best defined by the 21-day neuroimaging, with recognition that the full neurodevelopmental trajectory is not yet defined. An initial evaluation of each new therapy at this time point may allow higher-throughput selection of promising therapies for more extensive investigation. Functional recovery can be assessed using a trajectory of neurodevelopmental evaluations targeted to a pre-specified and mechanistically-derived hypothesis of drug action. As precision medicine revolutionizes healthcare, it should also include the redesign of NE clinical trials to allow safe, efficient and targeted therapeutics.

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Section: Intermediate and Long-term Neurophysiology And Developmentmentioning

confidence: 99%

Section: Perspectives From the Sprmentioning

confidence: 99%

Section: Perspectives From the Sprmentioning

confidence: 99%

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Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future

et al. 2020

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“…Globally, approximately ve to 18% (15 million) of neonates are born preterm of all the live births [2]. Very preterm babies born less than or equivalent to 32 weeks of gestation are at high-risk of impaired cognitive, sensory, motor, emotional, language, and behavioral development when compared to the full-term infants [3]. Early brain injury and impaired brain development are reasons for the aforementioned problems [4].…”

Section: Description Of the Conditionmentioning

confidence: 99%

Effect of Family-centered Care Interventions on Motor and Neurobehavior Development of Very Preterm Infants: A Protocol of Systematic Review

Raghupathy

Rao

Nayak

et al. 2020

Preprint

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Background: Globally, preterm birth is a health concern leading to various developmental difficulties such as poor motor and/or cognitive function. For infants born preterm, FCC promotes developmental skills over the time in an appropriate enriched environment. The purpose of this study is to systematically review and assess the evidence of FCC interventions on motor and neurobehavioral development in very preterm infants. Additionally, this review aims to determine the factors that might affect the infant development.Methods: Systematic review will be carried out by including quasi-experimental controlled trials and randomized controlled trials. Electronic databases such as Scopus, PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, and PsycINFO will be searched using database specific terms. Additionally, searches will be carried out in ProQuest, and references of included studies will be searched. Two review authors, independently, will conduct the screening, data extraction, and critical appraisal of included studies. If possible, meta-analysis will be undertaken to assess the effect of FCC on motor and neurobehavior of premature infants.Conclusion: The review will provide insights regarding the effect of the FCC on preterm infants. This systematic review will guide the clinicians on the feasibility of practicing FCC that might support and promote the integration of parents into various rehabilitation settings.Systematic review registration: Protocol has been submitted to PROSPERO on July 26, 2020.

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“…We demonstrated identification of infants at risk of adverse motor outcomes and CP at 2 years CA using early MRI and clinical biomarkers. [7][8][9] To our knowledge, the PREBO cohort is now one of four worldwide with >100 very preterm infants with early MRI and neurodevelopmental outcomes, and the only study with MRI at 3T.…”

Section: Introduction Background and Rationalementioning

confidence: 99%

Prediction of childhood brain outcomes in infants born preterm using neonatal MRI and concurrent clinical biomarkers (PREBO-6): study protocol for a prospective cohort study

et al. 2020

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IntroductionInfants born very preterm are at risk of adverse neurodevelopmental outcomes, including cognitive deficits, motor impairments and cerebral palsy. Earlier identification enables targeted early interventions to be implemented with the aim of improving outcomes.Methods and analysisProtocol for 6-year follow-up of two cohorts of infants born <31 weeks gestational age (PPREMO: Prediction of Preterm Motor Outcomes; PREBO: Prediction of Preterm Brain Outcomes) and a small term-born reference sample in Brisbane, Australia. Both preterm cohorts underwent very early MRI and concurrent clinical assessment at 32 and 40 weeks postmenstrual age (PMA) and were followed up at 3, 12 and 24 months corrected age (CA). This study will perform MRI and electroencephalography (EEG). Primary outcomes include the Movement Assessment Battery for Children second edition and Full-Scale IQ score from the Wechsler Intelligence Scale for Children fifth edition (WISC-V). Secondary outcomes include the Gross Motor Function Classification System for children with cerebral palsy; executive function (Behavior Rating Inventory of Executive Function second edition, WISC-V Digit Span and Picture Span, Wisconsin Card Sorting Test 64 Card Version); attention (Test of Everyday Attention for Children second edition); language (Clinical Evaluation of Language Fundamentals fifth edition), academic achievement (Woodcock Johnson IV Tests of Achievement); mental health and quality of life (Development and Well-Being Assessment, Autism Spectrum Quotient-10 Items Child version and Child Health Utility-9D).AimsExamine the ability of early neonatal MRI, EEG and concurrent clinical measures at 32 weeks PMA to predict motor, cognitive, language, academic achievement and mental health outcomes at 6 years CA.Determine if early brain abnormalities persist and are evident on brain MRI at 6 years CA and the relationship to EEG and concurrent motor, cognitive, language, academic achievement and mental health outcomes.Ethics and disseminationEthical approval has been obtained from Human Research Ethics Committees at Children’s Health Queensland (HREC/19/QCHQ/49800) and The University of Queensland (2019000426). Study findings will be presented at national and international conferences and published in peer-reviewed journals.Trial registration numberACTRN12619000155190p.Web address of trialhttp://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12619000155190p

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Relationship between very early brain structure and neuromotor, neurological and neurobehavioral function in infants born <31 weeks gestational age

Cited by 33 publications

References 37 publications

Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future

Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future

Effect of Family-centered Care Interventions on Motor and Neurobehavior Development of Very Preterm Infants: A Protocol of Systematic Review

Prediction of childhood brain outcomes in infants born preterm using neonatal MRI and concurrent clinical biomarkers (PREBO-6): study protocol for a prospective cohort study

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Relationship between very early brain structure and neuromotor, neurological and neurobehavioral function in infants born <31 weeks gestational age

Cited by 33 publications

References 37 publications

Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future

Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future

Effect of Family-centered Care Interventions on Motor and Neurobehavior Development of Very Preterm Infants: A Protocol of Systematic Review

Prediction of childhood brain outcomes in infants born preterm using neonatal MRI and concurrent clinical biomarkers (PREBO-6): study protocol for a prospective cohort study

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Relationship between very early brain structure and neuromotor, neurological and neurobehavioral function in infants born <31 weeks gestational age