Relationship between variation of seasonal temperature and extent of occupational exposure to phthalates

Pilka, Tomáš; Petrovičová, Ida; Kolena, Branislav; Zatko, Tomás; Trnovec, T.

doi:10.1007/s11356-014-3385-7

Cited by 33 publications

(20 citation statements)

References 21 publications

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“…Biomonitoring studies in other European countries, including France [83], Belgium [65,66], Slovakia [117], and Norway [112], report phthalate metabolite concentrations in the range of 1–100 μg/L in urine from adults. MBP and DEHP metabolites were the predominant compounds found in those studies.…”

Section: Biomonitoring Of Phthalatesmentioning

confidence: 99%

A Review of Biomonitoring of Phthalate Exposures

Wang

Zhu

Kannan

2019

Toxics

503

280

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Phthalates (diesters of phthalic acid) are widely used as plasticizers and additives in many consumer products. Laboratory animal studies have reported the endocrine-disrupting and reproductive effects of phthalates, and human exposure to this class of chemicals is a concern. Several phthalates have been recognized as substances of high concern. Human exposure to phthalates occurs mainly via dietary sources, dermal absorption, and air inhalation. Phthalates are excreted as conjugated monoesters in urine, and some phthalates, such as di-2-ethylhexyl phthalate (DEHP), undergo secondary metabolism, including oxidative transformation, prior to urinary excretion. The occurrence of phthalates and their metabolites in urine, serum, breast milk, and semen has been widely reported. Urine has been the preferred matrix in human biomonitoring studies, and concentrations on the order of several tens to hundreds of nanograms per milliliter have been reported for several phthalate metabolites. Metabolites of diethyl phthalate (DEP), dibutyl- (DBP) and diisobutyl- (DiBP) phthalates, and DEHP were the most abundant compounds measured in urine. Temporal trends in phthalate exposures varied among countries. In the United States (US), DEHP exposure has declined since 2005, whereas DiNP exposure has increased. In China, DEHP exposure has increased since 2000. For many phthalates, exposures in children are higher than those in adults. Human epidemiological studies have shown a significant association between phthalate exposures and adverse reproductive outcomes in women and men, type II diabetes and insulin resistance, overweight/obesity, allergy, and asthma. This review compiles biomonitoring studies of phthalates and exposure doses to assess health risks from phthalate exposures in populations across the globe.

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Section: Biomonitoring Of Phthalatesmentioning

confidence: 99%

A Review of Biomonitoring of Phthalate Exposures

Wang

Zhu

Kannan

2019

Toxics

503

280

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“…Hairdressing apprentices provided first spot urine samples (2 × 2 mL) at the beginning of work, not earlier than 6:00 am, at the end of the workweek (Friday, work duration at least 8 h per shift), which gives information about individual exposures during last 24 h. Samples were stored in a transport box at 2-6 • C and then in the deep freezer at −73 • C until analysis. We used high-performance liquid chromatography (HPLC) and tandem mass spectrometry (MS/MS) (Infinity 1260 and 6410 triplequad, Agilent, Santa Clara, CA, USA) to quantified urinary concentration of compounds: MEP, MnBP, MEHP, MEHHP, MEOHP by the method of Pilka et al [42]. The method was certificated for occupational/environmental medical-toxicological analysis for the Environmental medical field by EQUAS in German External Quality Assessment Scheme.…”

Section: Phthalate Analysesmentioning

confidence: 99%

Phthalates Exposure and Occupational Symptoms among Slovakian Hairdressing Apprentices

et al. 2019

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The objectives of the study were to examine occupational exposure to phthalates of hairdressing apprentices from Slovakia (n = 74, 89.2% females; 10.8% males), outcomes related to body composition and pulmonary functions. We used high-performance liquid chromatography and tandem mass spectrometry to the quantified urinary concentration of phthalates. Pulmonary function test (PFT), anthropometric measurements, and questionnaire were also conducted. We observed a decrease of % of predicted values of forced vital capacity (FVC% of PV) related exposure to mono(2-ethyl-5-oxohexyl) phthalate (MEOHP; p = 0.054) and sum of bis(2-ethylhexyl) phthalate metabolites ( DEHP; p = 0.037), and a decrease of % of predicted values of vital capacity (VC% of PV) related to exposure to MEOHP, DEHP (p = 0.008), and mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP; p = 0.014) in females. We detected associations between forced vital capacity (FVC) with weight (p = 0.002) and fat-free mass index (FFMI, p = 0.010). Vital capacity (VC) and VC% of PV increased with weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), the waist-height ratio (WHtR), fat mass index (FMI) and FFMI in females (p ≤ 0.014). Results of multivariate regression between PFT and anthropometric parameters adjusted to phthalates indicated exposure to MnBP and MEHP, changing body structure (BMI and FMI), subsequently affecting values of FEV 1 /FVC. Appl. Sci. 2019, 9, 3321 2 of 15 esters were determined in five salons from the ten monitored in Taiwan by a walkthrough survey. Although concentrations of diester phthalates (dibutyl phthalate, diethyl phthalate, dimethyl phthalate, di[2-ethylhexyl] phthalate, and butyl benzyl phthalate) were below the occupational exposure limits, they were higher than what was found in general residential environments [19]. As a result, hairdressers are frequently occupationally exposed to phthalates contained in beauty products [20,21]. Health complications that affected various mucosal surfaces and oral and skin lesions, either independently or concurrently, have been significantly increased in the hairdressing apprentices [12,[22][23][24]. Dysfunction of pulmonary, immune, and other systems [10,[25][26][27] have been among various potential health impacts often ascribed to these exposures. The occupational environment of hairdressers has been found hazardous for the initiation of airway syndromes, varying from bronchial irritation to asthma [28] with a prevalence of 5%-25% [29][30][31]. Although most patients with occupational asthma are mature adults, there is evidence that the inflammation of airways started soon after early exposures in hairdressing apprenticeship [32,33]. Associations with other respiratory diseases and symptoms were also reported [12,[34][35][36][37][38][39][40]. Concerning outcomes of such exposures, as a possible mechanistic link to airway diseases, the modulatory effects on peroxisome proliferation activated receptors (PPAR) have been suggested [2].The aim of thi...

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“…, and mono-n-octyl phthalate (MnOP) were measured. We used high-performance liquid chromatography (HPLC) and tandem mass spectrometry (MS/MS) (Infinity 1260 and 6410 triple quad instruments, (Agilent Technology) using the method reported by [14]. Briefly, 1 ml of urine was thawed, buffered with ammonium acetate, spiked with isotopelabelled phthalate standards, β-glucuronidase enzyme (K12 E. Coli, Roche, Mannheim, Germany), and incubated (37ºC; 60 minutes).…”

Section: Data Collection By Questionnairementioning

confidence: 99%

Association between Consumer Practices and Phthalate Exposure in Children and their Parents from Slovakia

Hlisníková¹,

Šidlovská²,

Kolena³

et al. 2019

Pol. J. Environ. Stud.

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Phthalates represent endocrine disrupting chemicals, with harmful effect on the hormonal balance of the human body. Food is a substantial source of exposure to phthalates. The aim of study was to investigate association between phthalate exposure of children and their parents from Slovakia (children n = 51, parents n = 27) and their consumer practices. We analysed urine samples by high performance liquid chromatography and tandem mass spectrometry (HPLC-MS/MS) to determine concentrations of phthalate metabolites monoethyl phthalate (MEP), monomethyl phthalate (MMP), mono-n-buthyl phthalate (MnBP), mono-iso-buthyl phthalate (MiBP), monocyclo-hexyl phthalate (MCHP), mono(2ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono(2-ethyl-5-carboxypentyl) phthalate (MECPP) and mono(2carboxymethylhexyl) phthalate (McMHP), mono-n-octyl phthalate (MnOP) and mono-isononyl phthalate (MiNP). We observed significantly higher concentrations of di (2-ethylhexyl) phthalate (DEHP) metabolites and MiBP in children in comparison with parents (p≤0.05). We found statistically significant association between concentrations of some phthalates and consumption of food packed in the plastic containers, drinking of milk and strongest association was detected between consumption of sliced salami in a plastic package and concentrations of all DEHP metabolites (p≤0.05). We concluded that consumption of the fat rich food stored in the plastic containers together with socioeconomic status and age could affect urinary concentration of phthalate metabolites.

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Relationship between variation of seasonal temperature and extent of occupational exposure to phthalates

Cited by 33 publications

References 21 publications

A Review of Biomonitoring of Phthalate Exposures

A Review of Biomonitoring of Phthalate Exposures

Phthalates Exposure and Occupational Symptoms among Slovakian Hairdressing Apprentices

Association between Consumer Practices and Phthalate Exposure in Children and their Parents from Slovakia

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