Relationship between vacA Types and Development of Gastroduodenal Diseases

Trang, Trần Thị Huyền; Binh, Tran Thanh; Yamaoka, Yoshio

doi:10.3390/toxins8060182

Cited by 44 publications

(26 citation statements)

References 68 publications

(109 reference statements)

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“…Numerous studies have provided evidence for a stronger association of disease outcomes in individuals infected with H. pylori strains possessing active vac A genotypes such as s 1 and m 1 than that with less or non-active vac A types. 51 , 52 …”

Section: Discussionmentioning

confidence: 99%

Primary antibiotic resistance and its relationship with cagA and vacA genes in Helicobacter pylori isolates from Algerian patients

Bachir

Allem

Tifrit

et al. 2018

Brazilian Journal of Microbiology

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The epidemiology of Helicobacter pylori resistance to antibiotics is poorly documented in Africa and especially in Algeria. The aim of our study was to determine the antibiotic resistance rates, as well as its possible relationship with VacA and CagA virulence markers of isolates from Algerian patients. One hundred and fifty one H. pylori isolate were obtained between 2012 and 2015 from 200 patients with upper abdominal pain. Antimicrobial susceptibility testing was performed for amoxicillin, clarithromycin, metronidazole, ciprofloxacin, rifampicin and tetracycline. Molecular identification of H. pylori and the detection of vacA and cagA genes were performed using specific primers. We found that H. pylori was present in 83.5% of collected biopsies, 54.9% of the samples were cagA positive, 49.67% were vacA s1m1, 18.30% were vacA s1m2 and 25.49% were vacA s2m2. Isolates were characterized by no resistance to amoxicillin (0%), tetracycline (0%), rifampicin (0%), a high rate of resistance to metronidazole (61.1%) and a lower rate of resistance to clarithromycin (22.8%) and ciprofloxacin (16.8%). No statically significant relationship was found between vagA and cagA genotypes and antibiotic resistance results (p > 0.5) except for the metronidazole, which had relation with the presence of cagA genotype (p = 0.001).

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Section: Discussionmentioning

confidence: 99%

Primary antibiotic resistance and its relationship with cagA and vacA genes in Helicobacter pylori isolates from Algerian patients

Bachir

Allem

Tifrit

et al. 2018

Brazilian Journal of Microbiology

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“…Of the Sec-related proteins, SecA functions as an ATPase bound to a complex formed by inner membranebound Sec-related proteins. [36,38,39] Acidic pH of the gastric environment highly affects the bioaccessibility and bioavailability of chemicals. Sui et al reported that the degradation rate of C3G increased with an increase in pH and that degradation rate constants increased with an increase in temperature.…”

Section: Discussionmentioning

confidence: 99%

Regulatory Effects of Black Rice Extract on Helicobacter pylori Infection‐Induced Apoptosis

Kim

Lee

Park

et al. 2017

Molecular Nutrition Food Res

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“…In a recent meta-analysis, CagA with a single EPIYA-D motif was significantly associated with the development of gastric cancer while CagA with multiple EPIYA-C motifs was found to be a significant risk factor for peptic ulcer disease (PUD) in Asian countries; however, in the US and Europe, CagA with multiple EPIYA-C motifs was associated with the development of gastric cancer 21 . The VacA is an exotoxin which affects multiple cellular pathways and induces host cell vacuolation and cell death (reviewed in 22 ).…”

Section: Virulence Factors Implicated In Gastro-duodenal Diseasesmentioning

confidence: 99%

Current understanding and management of Helicobacter pylori infection: an updated appraisal

Ansari

Yamaoka

2018

F1000Res

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In addition to its role in gastric conditions, Helicobacter pylori has been found to contribute to the development of several non-gastric issues in recent years. Eradication therapy is the only effective management strategy to minimize the H. pylori-related gastric cancer and extra-gastric complications. For an effective “test and treat” strategy, diagnosis and therapy are both important. Because the infection is usually asymptomatic, patient selection is a critical issue for timely diagnosis and many clinical and demographic factors should be considered. Clarithromycin and metronidazole resistance rates also need to be considered while eradication therapy is offered. In this report, we discuss the issues which must be taken into account for the correct and timely diagnosis and for the antibiotic therapy-based management of H. pylori infection.

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Relationship between vacA Types and Development of Gastroduodenal Diseases

Cited by 44 publications

References 68 publications

Primary antibiotic resistance and its relationship with cagA and vacA genes in Helicobacter pylori isolates from Algerian patients

Primary antibiotic resistance and its relationship with cagA and vacA genes in Helicobacter pylori isolates from Algerian patients

Regulatory Effects of Black Rice Extract on Helicobacter pylori Infection‐Induced Apoptosis

Current understanding and management of Helicobacter pylori infection: an updated appraisal

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