Relationship Between Uveitis, Different Types of Viral Hepatitis, and Liver Cirrhosis

Tien, Peng-Tai; Lin, Chun-Ju; Tsai, Yi–Yu; Chen, Huansheng; Hwang, De‐Kuang; Muo, Chih‐Hsin; Lin, Jane-Ming

doi:10.1097/iae.0000000000001103

Cited by 16 publications

(15 citation statements)

References 29 publications

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“…The association between viral hepatitis and uveitis has been proposed in a few studies, most of which investigated the role of hepatitis B and C in the pathogenesis of uveitis. These studies noted that deposition of circulating immune complexes, physiologic immune reaction against an infection within the eye, and complement-mediated immune activation may lead to extra-hepatic manifestations such as glomerulonephritis, uveitis, and polyarteritis nodosa [ 3 – 5 ]. Tien at el.…”

Section: Discussionmentioning

confidence: 99%

“…in a cohort study on the relationship between uveitis and the different types of viral hepatitis concluded that patients with hepatitis B virus and HCV co-infection have the highest risk of uveitis. Also, They reported only one case of uveitis among 82 cases of isolated HAV infection (rate:19.44 per 10,000 person-years) [ 5 ]. The extra-hepatic manifestations which reported to be associated with HAV infection include glomerulonephritis, acute renal failure (ARF), myositis, acute pancreatitis, arthritis, pleural or pericardial effusion, myocarditis, autoimmune thrombocytopenic purpura, erythematous maculopapular rash, and parotitis.…”

Section: Discussionmentioning

confidence: 99%

“…Infections are the vision-threatening causes of AU which should be ruled out by history taking and physical examination combined with guided work up [ 2 ]. Uveitis is a rare complication of acute viral hepatitis B and C which has not been reported as a presentation or extra-hepatic manifestation of hepatitis A virus (HAV) infection so far [ 3 – 5 ]. Hepatitis A is a self-limited viral infection with an average 30 days (range 15 to 49 days) of incubation period [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report

Azimi

Shirvani

Hosseini

et al. 2020

J Ophthal Inflamm Infect

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Anterior uveitis (AU) is the most common form of uveitis. The differential diagnosis of AU is broad, ranging from infectious etiologies to autoimmune causes. However, approximately half remain idiopathic. Infections are the vision-threatening causes of AU which should be ruled out by history taking and detailed physical examination combined with guided work up. We report a rare case of bilateral granulomatous AU following hepatitis A virus (HAV) infection in an immunocompetent patient. A 35-year-old male presented to our center with a chief complaint of pain and redness in both eyes 3 days prior to the presentation. The patient's medical and drug history was unremarkable. He had a history of river water consumption 20 days prior to presentation. The patient was diagnosed with acute bilateral granulomatous AU. All routine work up to investigate the etiology of the disease was unremarkable, except for the serology of acute HAV infection, which was positive. The patient was managed with the topical steroid and cycloplegic for 2 weeks with no recurrence at one-year follow up. Extra-hepatic complications of HAV were reported in previous studies including arthritis, urticaria, myocarditis, nephritis, and myositis. The mechanism of extra-hepatic complication of hepatitis A is unknown; however, immune-complex deposition is most likely the etiological cause. Our report represents a rare case of sudden onset with limited duration granulomatous AU as a presenting manifestation of HAV infection. Previous studies do not provide a direct evidence of granulomatous AU associated with the HAV infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report

Azimi

Shirvani

Hosseini

et al. 2020

J Ophthal Inflamm Infect

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“…(2) Uveitis is a rare complication of acute viral hepatitis B and C which has not been reported as a presentation or extra-hepatic manifestation of hepatitis A virus (HAV) infection so far. (3,4,5) Hepatitis A is a self-limited viral infection with an average 30 days (range 15 to 49 days) of incubation period. (6) In this case study we report a rare case of bilateral granulomatous AU as an extra-hepatic manifestation of HAV infection in an immunocompetent patient.…”

Section: Introductionmentioning

confidence: 99%

Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: A case report

Azimi

Shirvani²,

Hosseini

et al. 2020

Preprint

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Anterior uveitis (AU) is the most common form of uveitis. The differential diagnosis of AU is broad, ranging from infectious etiologies to autoimmune causes. However, approximately half remain idiopathic. Infections are the vision-threatening causes of AU which should be ruled out by history taking and detailed physical examination combined with guided work up. We report a rare case of bilateral granulomatous AU following hepatitis A virus (HAV) infection in an immunocompetent patient. A 35-year-old male presented to our center with a chief complaint of pain and redness in both eyes 3 days prior to the presentation. The patient’s medical and drug history was unremarkable. He had a history of river water consumption 20 days prior to presentation. The patient was diagnosed with acute bilateral granulomatous AU. All routine work up to investigate the etiology of the disease was unremarkable, except for the serology of acute HAV infection, which was positive. The patient was managed with the topical steroid and cycloplegic for two weeks with no recurrence at one-year follow up. Extra-hepatic complications of HAV were reported in previous studies including arthritis, urticaria, myocarditis, nephritis, and myositis. The mechanism of extra-hepatic complication of hepatitis A is unknown; however, immune-complex deposition is most likely the etiological cause. Our report represents a rare case of sudden onset with limited duration granulomatous AU as a presenting manifestation of HAV infection. Previous studies do not provide a direct evidence of granulomatous AU associated with the HAV infection. Keywords ● uveitis ● hepatitis A virus ● infection ● visual acuity.

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“…In addition, the virus may infect lymphatic cells or induce chronic low-grade inflammation that secondarily influences DR, the pathogenesis of which is known to include a prominent inflammatory component. The potential contribution of HCV to inflammatory ocular disease is highlighted by a recent study suggesting higher rates of uveitis among patients with HCV infection 9…”

Section: Introductionmentioning

confidence: 99%

<p>Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy</p>

Koenig

Rosenblatt

Patel

et al. 2019

OPTH

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Purpose There are limited and conflicting data regarding the impact of comorbid hepatitis C virus (HCV) infection on diabetic retinopathy (DR). This study sought to compare the prevalence and severity of DR among patients with diabetes mellitus (DM) with and without HCV. Patients and methods This was a retrospective, case–control study of patients with DM comparing 120 patients with comorbid HCV and 120 age-matched controls. DR prevalence and several measures of severity were compared between groups. Subgroup analyses were performed among HCV patients with cirrhosis, comorbid HIV, or history of treatment with interferon. Statistical analysis for between-group comparisons utilized both univariate and multivariate analyses. Results Cases and controls exhibited similar baseline characteristics: average hemoglobin A1c, DM duration, and age ( p >0.05). Among cases and controls, there was no difference in DR prevalence (35.8% versus 42.5%, respectively, p =0.29) or severity ( p >0.05). Within the HCV subgroup, DR severity was reduced in patients with HIV or cirrhosis. However, multivariate analysis identified reduced DM duration in these subgroups as the primary contributor to lesser DR severity, rather than HIV or cirrhosis. Conclusion In this study, comorbid HCV did not modulate the prevalence or severity of DR among patients with DM. These findings may inform clinical monitoring among HCV-positive diabetics undergoing ophthalmic evaluation.

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Relationship Between Uveitis, Different Types of Viral Hepatitis, and Liver Cirrhosis

Cited by 16 publications

References 29 publications

Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report

Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report

Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: A case report

<p>Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy</p>

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