Relationship Between Urolithiasis and Fatty Liver Disease: Findings in Computed Tomography

Badillo, Federico Guillermo Lubinus; Cala, Óscar Leonel Ortiz; Campos, Silvia Nathalia Vera; Ibañez, Erick Daniel Villarreal

doi:10.18383/j.tom.2020.00020

Cited by 2 publications

(1 citation statement)

References 23 publications

(19 reference statements)

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“…Federico et al. also confirmed a relationship between urolithiasis and fatty liver disease [ 29 ]. Dyslipidemia was stated to be risk factor for urolithiasis and could serve as the bridge between urolithiasis and these systemic diseases [ 30 ].…”

Section: Discussionmentioning

confidence: 90%

Sex disparities and the risk of urolithiasis: a large cross-sectional study

Liu

Xia

et al. 2022

Annals of Medicine

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Section: Discussionmentioning

confidence: 90%

Sex disparities and the risk of urolithiasis: a large cross-sectional study

Liu

Xia

et al. 2022

Annals of Medicine

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Association between metabolic dysfunction-associated steatotic liver disease and risk of urolithiasis: an updated systematic review and meta-analysis

Mantovani,

Morandin,

Fiorio

et al. 2024

Intern Emerg Med

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Epidemiological studies have reported an association between metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of urolithiasis. However, the magnitude of the risk and whether this risk varies with the severity of MASLD remains uncertain. We performed a meta-analysis of observational studies to quantify the magnitude of the association between MASLD and urolithiasis. We systematically searched PubMed, Scopus, and Web of Science from database inception to March 31, 2024, using predefined keywords to identify relevant observational studies in which imaging methods or survey questionnaires diagnosed MASLD and urolithiasis. Meta-analysis was performed using random-effects modelling. We identified seven cross-sectional studies and one prospective cohort study with aggregate data on 248,936 adults from different countries. MASLD was significantly associated with an increased risk of prevalent urolithiasis (pooled random-effects odds ratio 1.87, 95% CI 1.34–2.60; I2 = 91%). This association remained significant in those studies whose results were adjusted for age, sex, ethnicity, obesity, diabetes, and other potential confounders. There was a positive graded association between the ultrasonographic severity of MASLD and urolithiasis. Meta-analysis of the single prospective cohort study showed that MAFLD was not associated with risk of developing incident urolithiasis (pooled random-effects hazard ratio 1.08, 95% CI 0.90–1.30), although a significant association was reported in men. Sensitivity analyses did not modify these findings. The funnel plot did not reveal any significant publication bias. This updated meta-analysis provides evidence for a significant association between MASLD and the presence of urolithiasis. Whether MASLD is associated with a higher risk of developing incident urolithiasis remains to be established.

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Relationship Between Urolithiasis and Fatty Liver Disease: Findings in Computed Tomography

Cited by 2 publications

References 23 publications

Sex disparities and the risk of urolithiasis: a large cross-sectional study

Sex disparities and the risk of urolithiasis: a large cross-sectional study

Association between metabolic dysfunction-associated steatotic liver disease and risk of urolithiasis: an updated systematic review and meta-analysis

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