Relationship between Urinary Pesticide Metabolites and Pest Control Operation among Occupational Pesticide Sprayers

Kimata, Akiko; Kondo, Takaaki; Ueyama, Jun; Yamamoto, Kenzo; Mochizuki, Aiko; Asai, K.; Takagi, Kenji; Okamura, Ai; Wei, Dong; Kamijima, Michihiro; Nakajima, Tamie; Fukaya, Yukio; Shibata, Eiji; Gotoh, Manabu; Saito, Isao

doi:10.1539/joh.m7005

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…Two of the cis-isomers, namely the 1R,cis- and 1S,cis-stereoisomers make up α-cypermethrin, the most active pair of the cypermethrin isomers [4] , [7] . The urinary concentrations of 3-phenoxybenzoic acid, a cypermethrin metabolite, were positively correlated with the frequency of spraying in Japanese pest control operators [20] . Because of its widespread use, not only persons working with insecticides, but large parts of the population are regularly exposed to cypermethrin.…”

Section: Introductionmentioning

confidence: 96%

Dietary exposure to continuous small doses of α-cypermethrin in the presence or absence of dietary curcumin does not induce oxidative stress in male Wistar rats

et al. 2014

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Section: Introductionmentioning

confidence: 96%

Dietary exposure to continuous small doses of α-cypermethrin in the presence or absence of dietary curcumin does not induce oxidative stress in male Wistar rats

et al. 2014

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“…Among the contaminants that are likely to disturb brain development, cypermethrin (CYP) and other pyrethroid insecticides are highly relevant candidates as the general population is extensively exposed to this family of pollutants through dietary intake and residential application in gardens and homes for pest-control purposes [ 2 , 3 ]. CYP, and more generally, pyrethroids, are included in over 3,500 registered products widely used in households including on pets, as treatment for clothing, mosquito control, and agriculture.…”

Section: Introductionmentioning

confidence: 99%

In utero and lactational exposure to low-doses of the pyrethroid insecticide cypermethrin leads to neurodevelopmental defects in male mice—An ethological and transcriptomic study

et al. 2017

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Accumulating evidence suggests that developmental exposure to environmental chemicals may modify the course of brain development, ultimately leading to neuropsychiatric / neurodegenerative disorders later in life. In the present study, we assessed the impact of one of the most frequently used pesticides in both residential and agricultural applications − the synthetic pyrethroid cypermethrin (CYP) − on developmental neurotoxicity (DNT). Female mice were perinatally exposed to low doses of CYP (5 and 20 mg/kg body weight) from gestation to postnatal day 15. Behavioral analyses were performed during the offspring’s early life and during adulthood. Postnatal analyses revealed that perinatal exposure to CYP disturbed motor development without modifying sensory and communicative skills. We found that later in life, CYP-exposed offspring expressed maladaptive behaviors in response to highly challenging tasks and abnormal sociability. Transcriptomic analyses performed in the offspring’s brain at the end of the exposure, highlighted mitochondrial dysfunction as a relevant pathomechanism underlying CYP-induced DNT. Interestingly, several genes involved in proteostasis maintenance were also shown to be dysregulated suggesting that alterations in biogenesis, folding, trafficking and degradation of proteins may significantly contribute to CYP-related DNT. From a regulatory perspective, this study highlights that behavioral and transcriptomic analyses are complementary tools providing useful direction for better DNT characterization, and as such, should be used together more systematically.

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“…The ill effects of pyrethroids and 3-PBA are massive ingestion include agitation, hypersensitivity, tremor, salivation, choreoathetosis and seizures [24][25][26]. There is strong evidence of its role in determining the exposure of pyrethroids in occupational workers [27]. Thus, it is necessary to detect and analyze 3-PBA so that the implications of pyrethroids on human health can be known.…”

Section: Introductionmentioning

confidence: 99%

Optical sensing of 3-phenoxybenzoic acid as a pyrethroid pesticides exposure marker by surface imprinting polymer capped on manganese-doped zinc sulfide quantum dots

Pandey

Chauhan

Pandey

et al. 2015

Analytical Chemistry Research

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a b s t r a c tThe present communication deals with the synthesis of luminescent Mn-doped ZnS quantum dots (QDs) anchored to surface imprinted polymer for the optical sensing of 3-phenoxy benzoic acid (3-PBA) in urine samples. The combination of sensing and surface functionalization not only improves the selectivity of the method, but also increases the optosensing ability of the material for non-phosphorescent substances. The developed material was utilized for the selective and sensitive detection of 3-PBA in urine samples. The proposed method shows good linearity with a regression coefficient (R 2 ) of 0.98. The limit of detection was found to be 0.117 lM. The method has an acceptable precision and accuracy which are found to be less than 8% and 80-90% respectively at three different concentrations. The quenching constant of quantum dot-molecular imprinted polymer was found to be 3.4 times higher to that of the quantum dot-non imprinted polymer (QD-NIP) as calculated by Stern-Volmer equation. The sensing method developed has shown immense utility to detect 3-PBA in complex biological samples like urine. Ó 2015 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

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Relationship between Urinary Pesticide Metabolites and Pest Control Operation among Occupational Pesticide Sprayers

Cited by 8 publications

References 25 publications

Dietary exposure to continuous small doses of α-cypermethrin in the presence or absence of dietary curcumin does not induce oxidative stress in male Wistar rats

Dietary exposure to continuous small doses of α-cypermethrin in the presence or absence of dietary curcumin does not induce oxidative stress in male Wistar rats

In utero and lactational exposure to low-doses of the pyrethroid insecticide cypermethrin leads to neurodevelopmental defects in male mice—An ethological and transcriptomic study

Optical sensing of 3-phenoxybenzoic acid as a pyrethroid pesticides exposure marker by surface imprinting polymer capped on manganese-doped zinc sulfide quantum dots

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