Relationship between urinary bisphenol a levels and cardiovascular diseases in the U.S. adult population, 2003–2014

Cai, Shengguan; Rao, Xianming; Ye, Jianhong; Ling, Yuxiao; Mi, Shuai; Chen, Hanzhu; Fan, Chunhong; Li, Yingjun

doi:10.1016/j.ecoenv.2020.110300

Cited by 44 publications

(22 citation statements)

References 61 publications

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“…Using 2003-2008 data, researchers determined that higher urinary BPA levels were strongly associated with weight circumference (WC) and BMI in males and females over 20 years of age (Shankar et al, 2012). Cai et al used NHANES 2003 data to determine that higher levels of BPA were associated with increased total CVD burden in males; however, no results were determined in female groups (Cai et al, 2020). Through analysis of 2003-2004 data, Lang et al, similarly demonstrated that CVD was associated with relatively high levels of BPA compared to lower quartiles and that an increase in CVD was associated with a one standard deviation increase of BPA (Lang et al, 2008).…”

Section: Exposure To Plasticizers and Risk For Metabolic Syndrome: Epmentioning

confidence: 99%

Plasticizers and Cardiovascular Health: Role of Adipose Tissue Dysfunction

et al. 2021

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Since the 1950s, the production of plastics has increased 200-fold, reaching 360 million tonnes in 2019. Plasticizers, additives that modify the flexibility and rigidity of the product, are ingested as they migrate into food and beverages. Human exposure is continuous and widespread; between 75 and 97% of urine samples contain detectable levels of bisphenols and phthalates, the most common plasticizers. Concern over the toxicity of plasticizers arose in the late 1990s, largely focused around adverse developmental and reproductive effects. More recently, many studies have demonstrated that exposure to plasticizers increases the risk for obesity, type 2 diabetes, and cardiovascular disease (CVD). In the 2000s, many governments including Canada, the United States and European countries restricted the use of certain plasticizers in products targeted towards infants and children. Resultant consumer pressure motivated manufacturers to substitute plasticizers with analogues, which have been marketed as safe. However, data on the effects of these new substitutes are limited and data available to-date suggest that many exhibit similar properties to the chemicals they replaced. The adverse effects of plasticizers have largely been attributed to their endocrine disrupting properties, which modulate hormone signaling. Adipose tissue has been well-documented to be a target of the disrupting effects of both bisphenols and phthalates. Since adipose tissue function is a key determinant of cardiovascular health, adverse effects of plasticizers on adipocyte signaling and function may underlie their link to cardiovascular disease. Herein, we discuss the current evidence linking bisphenols and phthalates to obesity and CVD and consider how documented impacts of these plasticizers on adipocyte function may contribute to the development of CVD.

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Section: Exposure To Plasticizers and Risk For Metabolic Syndrome: Epmentioning

confidence: 99%

Plasticizers and Cardiovascular Health: Role of Adipose Tissue Dysfunction

et al. 2021

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“…Previous studies have reported that urinary BPA is positively associated with an increased prevalence of total CVD in the U.S. population (Cai et al 2020;Hu et al 2019). Another study has shown a positively association between BPA and CVD (Melzer et al 2010).…”

Section: Discussionmentioning

confidence: 96%

“…The survey is unique in its combination of interviews, physical examinations, and laboratory tests designed with a multi-level probability sampling. All participants provided informed consent when they were recruited to participate in the study (Cai et al 2020). The National Center for Health Statistics Research Ethics Review Board has approved the implementation of the protocol for NHANES (Cai et al 2020).…”

Section: Study Populationmentioning

confidence: 99%

“…All participants provided informed consent when they were recruited to participate in the study (Cai et al 2020). The National Center for Health Statistics Research Ethics Review Board has approved the implementation of the protocol for NHANES (Cai et al 2020). From 2013 to 2016, a total of 1,266 NHANES participants with available bisphenols data and CVD data were included in the nal analysis.…”

Section: Study Populationmentioning

confidence: 99%

“…Bisphenol A (BPA) has long been used in plastics (Eladak et al 2015;Casey and Neidell 2013). The higher concentrations of BPA were associated with CVD (Cai et al 2020), obesity (Shankar, Teppala, and Sabanayagam 2012), diabetes (Stojanoska et al 2017), and hypertension(Commodore-Mensah et al 2018), brain (Santoro et al 2019), and reproductive system damage (Pivonello et al 2020). However, due to these adverse effects, some countries starting to ban or restrict the use of BPA in consumer products.…”

Section: Introductionmentioning

confidence: 99%

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The Bisphenol F and Bisphenol S and Cardiovascular disease: results from NHANES 2013-2016

wang¹,

Fei²,

Liu³

et al. 2021

Preprint

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Background Bisphenol F (BPF) and bisphenol S (BPS) are replacing bisphenol A (BPA) in the manufacturing of products containing polycarbonates and epoxy resins, however, the effects of these substitutes on the risk of cardiovascular disease (CVD) have not been assessed. Objective To examine the association of urinary BPS and BPF with the CVD risk in a U.S. representative population. Method A cross-sectional data with 1,266 participants aged 20 to 80 years from the 2013–2016 National Health and Nutrition Examination Survey (NHANES) was analyzed. The logistic regression was used to assess the association between BPF, BPS and CVD. The Bayesian kernel machine regression (BKMR) model was applied to assess the mixed effect. Results A total of 138 patients with CVD were identified. After adjusting for potential confounding factors, T3 concentration of BPS increased the risk of total CVD (OR: 1.98, 95%CI: 1.20–3.28). When stratified by age, we found that BPS increased the risk of CVD in the 50–80 age groups (OR:1.40, 95%CI: 1.05–1.87). BPS was positively associated with the risk of stroke and T3 of BPS increased the stroke risk by 3.46 times (95%CI: 1.09–10.95). No significant association was observed between BPF and CVD. Although BKMR model did not identify the mixed exposure effect of BPS, the risk of CVD increased, with the increase of compound concentration. Conclusion Our results suggest that BPS may increase the risk of total CVD and stroke in the U.S population, and prospective studies are needed to confirm the results.

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