Relationship between uric acid and lipid accumulation product index by gender in Korean adults: The 2016 Korean National Health and Nutrition Examination Survey

Seong, Jeong-Min; Park, Chang-Eun; Gi, Mi Young; Ae, Ju; Jung, Eun Young; Lee, Jun Ho; Sung, Hyun Ho; Yang, Seung Bum; Lee, Bae; Lim, Jae Heon; Yoon, Hyun Ju

doi:10.1016/j.pcd.2020.12.001

Cited by 9 publications

(8 citation statements)

References 38 publications

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“… 29 , 30 But in recent years, many scholars found that the IR and hyperuricemia were mutual causal relationship, even sometimes the hyperuricemia prior the IR occurs, IR enhances renal urate reabsorption via stimulation of uric acid transporter 1 and/or the Na-dependent anion co-transporter in brush border membranes or the renal proximal tubule; 31 , 32 and IR accelerates the rate of lipolysis and decreases adipose tissue lipoprotein lipase activity, 33 which in turn causes hyperlipemia and the subsequent over-production of uric acid; 34 on the contrary, the hyperuricemia can induce endothelial dysfunction and/or oxidative changes in adipocytes, which are typical stigmata of IR; 35 , 36 In this study, VAI was associated with SUA level, but when fully adjusted for age, gender, BMI and biomarkers, the association with hyperuricemia disappeared. In addition, previous study 37 found that LAP was positively associated with hyperuricemia. But contrary to our results, there was not association between the LAP and hyperuricemia.…”

Section: Discussionmentioning

confidence: 80%

Association Between the Cardiometabolic Index and Hyperuricemia in an Asymptomatic Population with Normal Body Mass Index

Zuo

Gao

Yin

et al. 2021

IJGM

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Section: Discussionmentioning

confidence: 80%

Association Between the Cardiometabolic Index and Hyperuricemia in an Asymptomatic Population with Normal Body Mass Index

Zuo

Gao

Yin

et al. 2021

IJGM

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“…The results of the present study confirm in a large general population sample the close relationships between SUA, lipid profile and adiposity indices (VAI, CMI and LAP) reported in previous studies. 10 , 11 , 12 , 15 , 16 , 17 They add to this information two novel sets of data. First, our study provides new data on the above mentioned SUA association in a clinical phenotype of common detection characterized by the concomitant presence of both lipids profile and adiposity indices alterations.…”

Section: Discussionmentioning

confidence: 99%

Uric acid relationships with lipid profile and adiposity indices: Impact of different hyperuricemic thresholds

Maloberti

Vanoli

Finotto

et al. 2022

J of Clinical Hypertension

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Previous studies focused on the relationships between Serum Uric Acid (SUA) and lipids have found an association mainly with triglycerides. Furthermore, previous studies on adiposity indices have been focused on the evaluation of the Visceral Adiposity Index (VAI). The present study was aimed at providing within the same population a systematic evaluation of lipids and adiposity indices with SUA, employing both the classic cutoff for hyperuricemia and the newly one identified by the Uric Acid Right for Heart Health (URRAH) study. We analyzed data collected in 1892 subjects of the Pressioni Arteriose Monitorate E loro Associazioni (PAMELA) study with available SUA, lipid profile and variables necessary to calculate VAI, Cardio-Metabolic Index (CMI) and Lipid Accumulation Product (LAP). At linear regression model (corrected for confounders) SUA correlated with all the lipids values (with the strongest β for triglycerides) and adiposity indices. When the two different cutoffs were compared, the URRAH one was significantly related to atherogenic lipids profile (OR 1.207 for LDL and 1.33 for non-HDL, P < 0.001) while this was not the case for the classic one.Regarding adiposity indices the classic cutoff displays highest OR as compared to the URRAH one. In conclusions, newly reported URRAH cutoff for hyperuricemia better relate to atherogenic lipoprotein (LDL and non-HDL) when compared to the classic one. The opposite has been found for adiposity indexes where the classic cut-off seems to present highest performance. Among adiposity indexes, LAP present the highest OR for the relationship with hyperuricemia.

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“…A number of epidemiological studies have reported an association between serum uric acid levels and the risk of DKD and DKD progression [20][21][22]. Lipid accumulation is known to be related to renal damage [23] and hyperuricemia [24]. A previous study also indicated that FABP3 was a possible marker linking lipid metabolism and renal damage [25].…”

Section: Discussionmentioning

confidence: 99%

Association of plasma fatty acid-binding protein 3 with estimated glomerular filtration rate in patients with type 2 diabetes mellitus

Yu¹,

Hsuan²,

Wu³

et al. 2022

Int. J. Med. Sci.

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Background: Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). Our previous study revealed that plasma FABP1 and FABP2 were independently associated with CKD, however, little is known about the relationship between plasma FABP3 level and CKD. The aim of this study was therefore to evaluate the plasma levels of FABP3 at different stages of estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 334 subjects with T2DM who enrolled in a disease management program were included in this study and stratified according to eGFR. Plasma FABP3 concentrations were measured by an enzyme-linked immunosorbent assay. Results: FABP3 levels increased in parallel with the eGFR level. Increasing concentrations of FABP3 were independently and significantly associated with eGFR stage G2-G4. Age-and sex-adjusted FABP3 levels were positively associated with uric acid, urinary albumin-to-creatinine ratio, FABP1, FABP2, and fatty liver index, but negatively associated with eGFR and hemoglobin. Conclusion:Our results indicate that circulating FABP3 in patients with T2DM is associated with eGFR, which suggests that increased plasma FABP3 may be involved in the pathogenesis of CKD.

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Relationship between uric acid and lipid accumulation product index by gender in Korean adults: The 2016 Korean National Health and Nutrition Examination Survey

Cited by 9 publications

References 38 publications

Association Between the Cardiometabolic Index and Hyperuricemia in an Asymptomatic Population with Normal Body Mass Index

Association Between the Cardiometabolic Index and Hyperuricemia in an Asymptomatic Population with Normal Body Mass Index

Uric acid relationships with lipid profile and adiposity indices: Impact of different hyperuricemic thresholds

Association of plasma fatty acid-binding protein 3 with estimated glomerular filtration rate in patients with type 2 diabetes mellitus

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