Relationship Between Ultraviolet Radiation-Induced Immunosuppression and Carcinogenesis

Streilein, J. Wayne; Taylor, J. Richard; Vincek, Vladimir; Kurimoto, Iwao; Richardson, Jeff; Tie, Cynthia; Medema, J. P.; Golomb, Cindy

doi:10.1038/jid.1994.19

Cited by 75 publications

(41 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Increased levels of proin¯ammatory and antiin¯am-matory cytokines in the skin or in the plasma have also been observed following UVR. As illustration, increases in proin¯ammatory cytokines such as IL-1b (Araneo et al, 1989;Gahring et al, 1984;Kupper et al, 1987;Oxholm et al, 1988), TNF-a (KoÈ ck et al, 1990;Oxholm et al, 1988;Streilein et al, 1994) and in antiin¯ammatory cytokines, mainly IL-4 and IL-10 (Araneo et al, 1989;Rivas & Ullrich, 1992;Shreedhar et al, 1998) were reported. Thus our observation, of increased levels of IL-1b and TNF-a, correlates well with previous reports and are in line with established role of these mediators in in¯ammatory reactions.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Modulation of ultraviolet‐induced hyperalgesia and cytokine upregulation by interleukins 10 and 13

Saadé

Nasr

Massaad

et al. 2000

British J Pharmacology

View full text Add to dashboard Cite

1 Exposure to midrange ultraviolet radiation (UVB) is known to produce skin in¯ammation similar to sunburn. The aim of this study was to characterize the hyperalgesia and cytokine upregulation induced by UVB and their modulation by antiin¯ammatory cytokines. 2 Acute exposure of the dorsal skin of mice to UVB (200, 250 and 300 mJ cm 2 ) resulted in a dosedependent decrease in the latencies of the hot plate and tail¯ick tests, without evident signs of skin lesions. 3 The observed hyperalgesia displayed a biphasic temporal evolution with an acute phase (3 ± 6 h) and a late (48 ± 96 h) phase. 4 Exposure to UVB (300 mJ cm 2 ) elicited signi®cant upregulation of interleukin (IL)-1b, tumour necrosis factor (TNF)-a and nerve growth factor (NGF), determined by ELISA in the exposed skin. This upregulation was more important during the acute phase of hyperalgesia. 5 Daily treatment of mice, with i.p. injections of either IL-10 or IL-13 (1.5, 7.5 and 15 ng in 100 ml saline) produced a dose-dependent attenuation of the UVB-induced hyperalgesia. 6 Treatment with the highest doses of either IL-10 or IL-13, produced signi®cant attenuation of the levels of the cytokines and NGF by UVB, with relatively more pronounced e ects by IL-13. 7 Acute exposure to moderate amounts of UVB results in a systemic hyperalgesia related to the upregulation of cytokine and NGF levels, since both were prevented by treatment with antiin¯ammatory cytokines.

show abstract

Section: Discussionmentioning

confidence: 96%

“…Prolonged or repetitive exposure to UVB, however, has been reported to lead to generalized immunosuppression (Streilein et al, 1994) through the production/secretion of antiin¯ammatory cytokines such as IL-4, and IL-10 (Araneo et al, 1989;Rivas & Ullrich, 1992;Shreedhar et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Modulation of ultraviolet‐induced hyperalgesia and cytokine upregulation by interleukins 10 and 13

Saadé

Nasr

Massaad

et al. 2000

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…7 Ultraviolet irradiation of the skin induces cytokine release, causing local and systemic immunosuppression. 9,10 The pro-inflammatory cytokines IL-1, 11 IL-6, 12 TNF-␣ 13 and TGF-␤ 14 are released from these activated keratinocytes. Members of the MAPkinase family such as c-Jun N-terminal kinases (JNK) and p38 are in turn activated by the cytokines IL-1 and TNF-␣.…”

mentioning

confidence: 99%

Opposite regulation of the HPV 20‐URR and HPV 27‐URR promoters by ultraviolet irradiation and cytokines

Ruhland

Villiers

2001

Int. J. Cancer

View full text Add to dashboard Cite

Epidemiological evidence implicates ultraviolet radiation and genetic changes (e.g., p53 mutations) as important factors in the etiology of nonmelanoma skin cancer. Little is known about a possible role of cutaneous papillomaviruses in these tumors. We previously reported both positive and negative regulation of the promoter activity of a number of HPV types by UV irradiation. To determine the underlying mechanism, we examined the influence of pro-inflammatory cytokines and MAP-kinases induced by UV irradiation by transfecting the HPV 20-URR and the HPV 27-URR into the RKO, HaCaT and H1299 cell lines expressing wild-type or mutated p53 or lacking p53, respectively. IL-1␣, IL-1␤, IL-6, IL-17, TNF-␣, as well as interferon-␣, -␤ and -␥ activated the promoter in the HPV 20-URR but inhibited the HPV 27-URR promoter. The effect of IL-1␣ and UV light was abolished by the addition of IL-1 receptor antagonist. UV irradiation induced a prolonged activation of JNK in HaCaT and H1299 but not in RKO cells, and its dephosphorylation was enhanced in the presence of p53 and the HPV-URRs. © 2001 Wiley-Liss, Inc. Key words: HPV; UV; cytokineEpidemiological evidence has implicated ultraviolet radiation as an important environmental factor in the pathogenesis of nonmelanoma skin cancer (NMSC). 1,2 These tumors occur mainly on sun-exposed sites, and differences in the prevalence of 100-fold for squamous-cell carcinoma and 50-fold for basal-cell carcinoma have been noted among the Caucasian populations of northern Europe and Australia. The incidence rates observed in the white population of Hawaii are, in comparison, substantially lower, possibly suggesting that factors other than changing sun-exposure patterns may play an important role in the etiology of these tumors. 3 Several genetic changes, partially induced by ultraviolet radiation, have been described. These are mutations in the p53 gene, the PTCH gene (chromosome 9q22.3), p21WAF1/CIP1 and p16 NK4/CDKN2A . 4 Papillomavirus (HPV) DNA has been demonstrated in NMSC occurring in renal transplant recipients, as well as in immunocompetent patients. A wide range of HPV types has been demonstrated in biopsies or surface-scrapings of normal skin, 5,6 as well as preand malignant lesions. 2,7 Even though controlled epidemiological studies have to date not been conducted, published data indicate that a few HPV types are more frequently demonstrable than others, independent of which PCR primers had been used for viral DNA amplification. 7,8 The influence of UV irradiation varies on the gene expression of a number of HPV types tested. These HPV types were selected according to their association with different types of skin lesions ranging from benign to malignant. UV irradiation activated the upper regulatory regions (URR) of HPV 1, 5, 7, 20 and 23, whereas it inhibited the URRs of HPV 2, 3, 27, 38 and 77. 4 No activity could be measured for the HPV 41 URR. The presence or absence of wild-type or mutated p53 influenced the gene expression of HPV 20, 27 and 77 but not HPV 41.HPV 20 and HPV ...

show abstract

“…We have no explanation for the mechanistic or biological relevance of this phenomenon. On the contrary, an increased isomerization propensity could have been anticipated, since cis-urocanic acid is an immune suppressive substance (7) and UV-induced immune suppression has been shown to be more readily induced in skin cancer patients than in their controls (26). We conclude that any crucial role of epidermal urocanic acid synthesis and UV-induced photoisomerization in the development of human skin cancer remains unproven.…”

Section: Discussionmentioning

confidence: 91%

Epidermal Urocanic Acid Concentration and Photoisomerization Reactivity in Patients with Cutaneous Malignant Melanoma or Basal Cell Carcinoma

Snellman

Ct²,

Rantanen³

et al. 1999

Acta Dermato-Venereologica

View full text Add to dashboard Cite

The relationship of epidermal urocanic acid concentration and photoisomerization reactivity to human skin cancer was studied. Twelve cutaneous malignant melanoma patients, 10 basal cell carcinoma patients and 22 healthy matched controls were enrolled in the study. A solar simulating ultraviolet irradiator was used for phototesting the minimal erythema dose. Using the Finn Chamber technique, urocanic acid was sampled from the healthy skin of the upper back, prior to and after exposure to suberythemal UV doses. The mean values of total and trans-urocanic acid were higher in basal cell carcinoma patients than in controls, but this difference was not statistically significant. No corresponding phenomenon was evident in the case of cutaneous malignant melanoma patients and their controls. Photoisomerization induced by irradiation with 1 mJ/cm2 CIE (Commission Internationale de l'Eclairage) was statistically significantly lower in cutaneous malignant melanoma patients than in controls (p=0.04). A similar trend was seen in basal cell carcinoma patients vs. their controls, but the difference was not significant.

show abstract

Relationship Between Ultraviolet Radiation-Induced Immunosuppression and Carcinogenesis

Cited by 75 publications

References 23 publications

Modulation of ultraviolet‐induced hyperalgesia and cytokine upregulation by interleukins 10 and 13

Modulation of ultraviolet‐induced hyperalgesia and cytokine upregulation by interleukins 10 and 13

Opposite regulation of the HPV 20‐URR and HPV 27‐URR promoters by ultraviolet irradiation and cytokines

Epidermal Urocanic Acid Concentration and Photoisomerization Reactivity in Patients with Cutaneous Malignant Melanoma or Basal Cell Carcinoma

Contact Info

Product

Resources

About