Relationship between ultra-widefield optical coherence tomography and ophthalmoscopy for detecting posterior inflammation in posterior uveitis and panuveitis

Abstract

Purpose To confirm the utility of ultra-widefield optical coherence tomography (W-OCT) for diagnosing uveitis. Method We retrospectively studied patients who had been diagnosed with uveitis and had undergone W-OCT. All patients had visited at Osaka Metropolitan University between January 2019 and January 2022. On W-OCT, vitreous opacity (“W-OCT VO”) and the presence of vitreous cells (“W-OCT Cells”) were identified by three specialists. We compared findings from ophthalmoscopy (“Ophthalmoscopic findings”) and fluorescein angiography (“FAG findings”) with those from W-OCT. Results This study investigated 132 eyes from 68 patients (34 males, 34 females; mean age, 53.97±22.71 years). Vitreous cells in posterior uveitis and panuveitis differed significantly between “W-OCT Cells” and “Ophthalmoscopic findings” for all cases (P = 0.00014). Vitreous opacities in posterior uveitis and panuveitis did not differ significantly between “W-OCT VO” and “Ophthalmoscopic findings” (P = 0.144) for all cases. Compared to “Ophthalmoscopic findings”, “W-OCT Cells” offered 51.1% sensitivity and 66.7% specificity for all cases (p<0.01). Compared to “Ophthalmoscopic findings”, “W-OCT VO” offered 78.6% sensitivity and 30% specificity for all cases (p = 0.19). In addition, “W-OCT Cells” did not differ significantly from “FAG findings” for all cases (P = 0.424). Conclusion W-OCT was shown to offer significantly greater sensitivity than ophthalmoscopy for detecting vitreous cells. The results of this study may add an option for the evaluation of uveitis.

Relationship between vitreous interleukin-6 levels and vitreous particles findings on widefield optical coherence tomography in posterior uveitis

“…WOCT is capable of imaging the retina at a wide angle, allowing evaluation of the peripheral retina. Articles reporting on the relationships between WOCT and clinical findings are increasing [ 5 , 6 ]. Recent studies have attempted to analyze OCT from various angles using image analysis software.…”

“…Optical coherence tomography (OCT) is an imaging modality that possibility of enables evaluation of the inflammatory degree [ 3 , 4 ]. In addition, Widefield OCT (WOCT) also allows imaging of the peripheral retina comparing with normal OCT, critical inflammatory diagnosis of uveitis using non-invasive methods [ 5 , 6 ].…”