Relationship between two-dimensional ultrasound measurement of placental thickness and estimated fetal weight

El-Bassioune²,

International Journal of Medical Arts

et al. 2020

Background: Placental thickness appears to be a promising parameter for estimation of gestational age of the fetus due to steady increase in placental thickness with gestational age. Aim of the work: To investigate the relationship between placental thickness and fetal outcome in patients with intrauterine growth restriction [IUGR]. Patients and Methods: This study included patients with fetuses diagnosed clinically and by ultrasound as IUGR [estimated fetal weight <10 th percentile for gestational age], singleton pregnancy, gestational age between 28-40 weeks of gestation, maternal age between 20-40 years old and body mass index between 18-30 kg/m 2. The placental thickness was measured at the second and third trimesters and correlated with the fetal outcome. Results: Results revealed that, estimated fetal weight significantly increased in normal placenta when compared to either thin or thick placentae. In addition, thin placentae had significantly low fetal birth weight [1936.4±409.2] when compared to thick placentae [2236.4±410.1] or normal placentae [2636.4±421.4]. Also, Apgar score was significantly higher and need for NICU admission were significantly lower with normal placentae. In addition, there is significant positive correlation between 3rd trimester placental thickness and fetal birth weight, placental weight and APGAR score. Conclusion: Placental thickness could predict deviations from norms of birth weight in late pregnancy. It seems to be promising for estimation of gestational age of the fetus and predicting fetal outcome.

Section: Disucssionsupporting

confidence: 93%

Section: Disucssionsupporting

confidence: 90%

Section: Disucssionmentioning

confidence: 81%

Section: Several Studies Have Reported An Association Between Small Pmentioning

confidence: 99%

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Relation Between Placental Thickness Measurements and Fetal Outcome in Patients with Intrauterine Growth Restriction (IUGR)

El-Bassioune²,

International Journal of Medical Arts

et al. 2020

“…In the current study it was found that, there was a statistically significant positive correlation between sonographic placenta thickness and foetal weight yielding a Pearson's correlation coefficient (r) of 0.902 for second trimester and 0.856 for third trimester within a P value of 0.001. This is in accordance with other documented Nigerian studies conducted by Abu and colleagues 31 and that carried out by Adeyekun et al 32 It is also in consonance with the study conducted by Maryam Afrakhteh et al 33 with 250 pregnant women (in Tajrish, Tehran, Iran) and Daskalakis et…”

Section: Relationship Between Fetal Weight and Placental Thicknesssupporting

confidence: 92%

Correlation of Placental Thickness in Relation to Gestational Age and Fetal Weight by using Ultrasonography

J¹,

Kallepally²

2019

IJCMSR

al 34 (in Athens, Greece) which are studies performed outside this country. Similar findings were reported during second and thirdtrimesters showing significant positive correlation placental thickness and fetal weights in studies by Elachel et al 35 , Ohagwu et al 36 , De Paula et al 37 , Daskalis et al 34 , Sanin et al 38 , Habib 39 , Abu et al 31 , Clapp et al 40 , Kinare et al 41 and previous studies. 30,32,42 EFWs showed a progressive increase in value throughout gestation.

Reactive Milieu of Hodgkin Lymphoma With Emphasis on Mast Cells and Macrophages

Kumar¹,

Pai²,

Halim³

2016

jemds

AIM OF STUDYTo study the clinical importance of reactive microenvironment in Hodgkin Lymphoma (HL) with special reference to macrophages and mast cells. MATERIALS AND METHODSThe present prospective and retrospective study was undertaken for a period ranging from January 2011 to June 2015 at the Department of Pathology, Kasturba Medical College, Mangalore. The Haematoxylin and Eosin (H and E) stained slides were reviewed and classified using WHO (2008) classification. Six immuno-histochemical markers were used in the study. CD 68 was for the macrophage count. Giemsa stain was done to highlight the mast cells. RESULTS AND ANALYSISThirty cases of HL were studied. Out of the 5 cases of Lymphocyte Depleted (LD) Classical Hodgkin Lymphoma (cHL), all cases showed high macrophage count. Out of 30 cases of HL, only 6 cases showed increased mast cell count. DISCUSSIONMast cells act actively in various types of cancers. They can either have a pro-tumorigenic function or an anti-tumorigenic function depending on the type of cancer. Four (80%) cases of LD-cHL showed macrophage count between 25-50% and 1 (20%) case showed macrophage count >50% correlating with the aggressive nature and advanced stage of the disease. CONCLUSIONIn this study of microenvironment of HL mast cells and macrophages were analysed in each subtype. Though the mast cells were seen in all cases, an increased count of >10/10 (High power field) HPF was observed only in 6 cases. The macrophage count was highest in LD-cHL and was statistically significant and thus correlated with this aggressive subtype of HL. The mast cell and macrophage count did not correlate with B-symptoms and stage of the disease a conclusion on survival versus the macrophage count and mast cell count was not possible in this study because of shorter follow up. A longer follow up and more number of cases are needed for a significant outcome.