Relationship between tumor infiltrating lymphocytes (Tils) and neutrophil-lymphocyte ratio (NLR) as a prognostic factor in patients with advanced non-small cell lung cancer.

Richardet, Eduardo; Hernández, Patricia; Richardet, Martin Eduardo; Cortes, Matias Nicolas; Molina, Matias; Acosta, Luciana Paola; Dicalbo, L.; Villavicencio, Rocio; Pets, Evelin; Paradelo, Martín

doi:10.1200/jco.2016.34.15_suppl.e20617

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the NLR has been widely used to analyze the severity and poor prognosis of acute and chronic diseases such as pancreatitis, renal failure, coronary heart disease, and neoplasms. [15][16][17][18][19][20] In addition, the NLR has been applied to predict poor prognosis in patients undergoing abdominal surgery, severe trauma, and acute renal injury. [21][22][23][24] However, to date, there have been few reports on the application of the NLR in multiple injuries.…”

Section: Discussionmentioning

confidence: 99%

“…NLR, as a simple and readily available index for inflammation evaluation, can be calculated directly from the patient's neutrophil and lymphocyte counts without any other invasive examinations. Therefore, the NLR has been widely used to analyze the severity and poor prognosis of acute and chronic diseases such as pancreatitis, renal failure, coronary heart disease, and neoplasms 15–20 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Neutrophil‐to‐lymphocyte ratio in relation to trauma severity as prognosis factors in patients with multiple injuries complicated by multiple organ dysfunction syndrome: A retrospective analysis

He,

Liu,

Zhong

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

ObjectiveThis study aimed to explore potential risk factors for the occurrence of multiple organ dysfunction syndrome (MODS) in patients with multiple injuries by evaluating neutrophil‐to‐lymphocyte ratio (NLR)‐associated trauma severity.MethodsThis retrospective case–control study included 95 patients with multiple injuries, who were admitted to our hospital (between January 2018 and December 2020). Clinical data including gender, age, underlying disease, number of injury sites (NIS), injury severity score (ISS), hemoglobin level within 24 h of admission (HL‐24h), neutrophil count (NC), white blood cell count, platelet count (PC), NLR, d‐dimer level, activated partial thromboplastin time (APTT), complicated shock within 24 h of admission (CS‐24h), length of stay, as well as prognostic outcome was systematically analyzed. According to MODS occurrence, patients were divided into a MODS group (n = 27) and a non‐MODS group (n = 68). The risk factors affecting patients with multiple injuries complicated by MODS were identified using univariate and multivariate logistic regression analyses. Candidate risk factors were further analyzed using receiver operating characteristic (ROC) curves.ResultsUnivariate analysis revealed a significant difference between the MODS and non‐MODA groups in terms of NIS, ISS, HL‐24h, PC, APTT, d‐dimer level, CS‐24h, NLR, NC, prognostic outcome, and other indicators (p < .05). Multivariate logistic regression analysis showed that d‐dimer levels within 24 h of admission and ISS, NLR, and CS‐24h were significantly associated with multiple injuries complicated by MODS. Compared with the non‐MODS controls, the NLR in the MODS group showed a much higher level and tended to rise with the increase in ISS score, indicating a significant intergroup difference (p < .05). The ROC curve analysis results suggested that the NLR had good sensitivity and specificity for predicting the prognosis of patients with MODS with multiple injuries.Conclusiond‐dimer level, ISS, NLR, and CS‐24h are important risk factors for MODS in patients with multiple injuries. Notably, NLR expression may be a good indicator of injury severity and predictor of the occurrence of MODS in patients with multiple injuries. Therefore, assessment of injury severity and coagulation function, active resuscitation, as well as prevention of infection should be emphasized during treatment of multiple injuries, to reduce and prevent the risk of MODS in patients with multiple injuries.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neutrophil‐to‐lymphocyte ratio in relation to trauma severity as prognosis factors in patients with multiple injuries complicated by multiple organ dysfunction syndrome: A retrospective analysis

He,

Liu,

Zhong

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

show abstract

Neutrophil-to-lymphocyte ratio in relation to trauma severity as prognosis factors in patients with multiple injuries complicated by multiple organ dysfunction syndrome：A Retrospective Analysis. (Preprint)

Liu¹,

He²,

Zhong³

et al. 2022

Preprint

View full text Add to dashboard Cite

BACKGROUND Multiple injuries refer to serious injuries to more than two sites and organs caused by one causative factor . Multiple injuries are severe and complicated, and are prone to secondary infection. Within the first 12 hours after trauma, the expression of some genes is up regulated in inflammatory cells and lymphocytes, leading to overexpression of some inflammatory factors . If effective interventions were not provided in time after trauma, once uncontrolled inflammatory reaction occurs, a chain waterfall reaction process of "systemic inflammatory response syndrome sepsis (SIRSS) multiple organ dysfunction syndrome (MODS) multiple organ failure" might be gradually developed, eventually, the patient even died. The incidence of MODS after multiple injuries has been reported to be 8.3% - 28%. MODS is a reversible dysfunction syndrome of two or more organs suffered from severe trauma, infection, or other damages. The essence of MODS is the over-activation of systemic inflammation, which is one of the major causes of death in critically ill patients. However, due to the reversibility of its process, early detection and attention to MODS and interruption of its progression by removing the cause and modulating inflammatory responses might be the key to treating MODS. Neutrophil lymphocyte ratio (NLR) is an emerging composite inflammatory biomarker in recent years, which is more and more recognized as a rapid reflection of a patient's immune and inflammatory status . Compared to other inflammatory markers such as C-reactive protein, NLR has its own characteristics. NLR integrates two distinct but complementary immune pathways, reflecting the degree of the body's stress response through lymphocyte counts. In addition, it reflects the degree of deterioration of systemic inflammatory response through neutrophil counts. A lower ratio of the two indicates a higher level of the body stress . Currently, research and application of NLR in multiple injury is still rare. Therefore, here we retrospectively reviewed the clinical data of patients with multiple injury treated in our hospital from January 2018 to December 2021. Risk factors for MODS patients with multiple injuries were systematically analyzed. Notably, the possibility of using NLR to predict MODS occurrence in multiple injury patients was also explored in detail. OBJECTIVE The aim of this study was to explore potential risk factors for the occurrence of multiple organ dysfunction syndrome (MODS) in patients with multiple injuries, by evaluating neutrophil-to-lymphocyte ratio (NLR)-associated trauma severity. METHODS A retrospective case-control study was performed on 95 patients with multiple injuries admitted to our hospital (from Jan. 2018 to Dec. 2020). Clinical data including gender, age, underlying disease, number of injury sites (NIS), injury severity score (ISS), hemoglobin level within 24 h of admission (HL-24h), neutrophil count (NC), white blood cell count (WBCC), platelet count (PC), NLR, D-dimer level, activated partial thromboplastin time (APTT), complicated shock within 24h of admission (CS-24h), length of stay, as well as prognostic outcome was systematically analyzed. According to MODS occurrence, patients were divided into MODS group (n = 27) and non-MODS group (n = 68), respectively. Risk factors affecting patients with multiple injuries complicated by MODS were identified using univariate and multivariate logistic regression analysis. The candidate risk factors were further analyzed with receiver operating characteristic (ROC) curves. RESULTS According to univariate analysis, significant difference was observed between MODS and non-MODA groups in NIS, ISS, HL-24h, platelet count, APTT, D-dimer level, CS-24h, NLR, NC, prognostic outcome and other indicators (P < 0.05). Multivariate logistic regression analysis results showed that D-dimer levels within 24 h of admission, ISS, NLR, and CS-24h were more significantly associated with multiple injuries complicated by MODS. Compared to the non-MODS controls, NLR in MODS groups showed a much higher level and up-regulated tendency with the increase of ISS score, indicating a significant inter-group difference (P < 0.05). ROC curve analysis results suggested that NLR had good sensitivity and specificity for prognosis predictions of MODS patients with multiple injuries. CONCLUSIONS Collectively, D-dimer levels, ISS, NLR, and CS-24h are all important risk factors for MODS patients with multiple injuries. Notably, NLR expression level might be a good indicator of the injury severity and a good predictor of the occurrence of MODS in patients with multiple injuries. Therefore, assessment of injury severity and coagulation function, active resuscitation, as well as prevention of infection should be emphasized during treatment of multiple injuries, to reduce and prevent the risk of MODS in patients with multiple injuries.

show abstract

Relationship between tumor infiltrating lymphocytes (Tils) and neutrophil-lymphocyte ratio (NLR) as a prognostic factor in patients with advanced non-small cell lung cancer.

Cited by 2 publications

References 0 publications

Neutrophil‐to‐lymphocyte ratio in relation to trauma severity as prognosis factors in patients with multiple injuries complicated by multiple organ dysfunction syndrome: A retrospective analysis

Neutrophil‐to‐lymphocyte ratio in relation to trauma severity as prognosis factors in patients with multiple injuries complicated by multiple organ dysfunction syndrome: A retrospective analysis

Neutrophil-to-lymphocyte ratio in relation to trauma severity as prognosis factors in patients with multiple injuries complicated by multiple organ dysfunction syndrome：A Retrospective Analysis. (Preprint)

Contact Info

Product

Resources

About