Relationship between TSH, T4, T3 and Prolactin in overweight and lean Sudanese PCOS Patients

Abdelsalam, Kamal Eldin Ahmed; Ibrahim, Waleed

doi:10.7439/ijbr.v6i2.1671

Cited by 6 publications

(4 citation statements)

References 29 publications

(28 reference statements)

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“…This study was found significant association between the level of prolactin and the BMI (Figure 4), and relatively high incidence of overweight among hyperprolactinemic patients, this finding is in complete agreement with recent study in India [18]. The study agree with Kamal Abdelsalam and Waleed Ibrahim who described an association between prolactin and obesity in Sudan [47].…”

Section: Discussionsupporting

confidence: 92%

Assessment of Thyroid Functions Test among Hyperprolactinemic Sudanese Infertile Females

Ahmed¹,

Elmahadi²,

Hamza³

et al. 2017

Health Sci J

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Section: Discussionsupporting

confidence: 92%

Assessment of Thyroid Functions Test among Hyperprolactinemic Sudanese Infertile Females

Ahmed¹,

Elmahadi²,

Hamza³

et al. 2017

Health Sci J

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“…Four studies were excluded after reading the full text (18,19,20,21). Two of them investigated the impact of subclinical hypothyroidism on the metabolic profile of PCOS; however, they also have a control group of healthy women without PCOS which does not meet the eligibility criteria (18,20).…”

Section: Excluded Studiesmentioning

confidence: 99%

“…Two of them investigated the impact of subclinical hypothyroidism on the metabolic profile of PCOS; however, they also have a control group of healthy women without PCOS which does not meet the eligibility criteria (18,20). One more study assessed the influence of different parameters on PCOS but did not investigate the outcomes assessed in the present meta-analysis (21).…”

Section: Excluded Studiesmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: The impact of subclinical hypothyroidism on anthropometric characteristics, lipid, glucose and hormonal profile of PCOS patients: a systematic review and meta-analysis

Pergialiotis

Konstantopoulos

Prodromidou

et al. 2017

European Journal of Endocrinology

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Objective: Subclinical hypothyroidism (SCH) is encountered in 10-25% of women with PCOS. To date, it remains unclear whether this coexistence influences the severity of metabolic and hormonal profile of these patients. The purpose of our systematic review is to investigate this potential relation. Methods: We systematically searched Medline, Scopus, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials (CENTRAL) and Google Scholar databases together with reference lists from included studies. All prospective and retrospective observational cohort studies that investigated the impact of subclinical hypothyroidism on hormonal and metabolic parameters of PCOS patients were included. The methodological quality of studies was assessed with the Ottawa-Newcastle criteria. Statistical meta-analysis was performed with the RevMan 5.3 software. Results: Twelve studies were finally included in the present review, which enrolled 2341 PCOS patients. Among them, 577 had subclinical hypothyroidism, whereas the remaining 2077 were PCOS women with normal thyroid function. The presence of SCH significantly affected HDL (MD -3.92 mg/dL 95% CI: -6.56, -1.29) and triglycerides levels (26.91 mg/dL 95% CI: -3.79, 50.02). HOMA-IR was also affected (MD 0.82 95% CI: 0.15, 1.50). On the other hand, LDL, fasting glucose and 2-h OGTT were not influenced. Similarly, prolactin, FSH, LH, LH/FSH ratio and sex hormone-binding globulin remained unaffected. Conclusion: Subclinical hypothyroidism does not influence the hormonal profile of women with PCOS. On the other hand, it results in mild metabolic abnormalities, which are not clinically important in a short-term setting.

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“…PCOS is thought to be a multifactorial dysfunction with a heterogeneous etiology. It has also been related to hypothyroidism in 6.3% of women with PCOS [28]. Women who test positive for thyroid antibodies do have 2-3-fold increased risk of spontaneous miscarriage compared to all those who test negative.…”

Section: Discussionmentioning

confidence: 99%

Effect of Metformin and Its Combination with Probiotic on Menstrual Irregularity and TSH Levels in Patients with Polycystic Ovarian Syndrome: A Randomized Controlled Trial

Zafar

Iqbal

Mughal

et al. 2021

JPRI

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Background: Polycystic ovarian syndrome (PCOS), the far most common endocrine disorder among sexually active women. The disease is typically characterized by irregular menstrual cycles and appears to be influenced by associated thyroid dysfunction. Aim: The goal of this research was to assess and compare the effects of Metformin and its combination with Probiotic on monthly cycle irregularity and TSH levels in PCOS women. Methodology: This was a single-center study conducted at Karachi's Gynecological Outpatient department from January 2019 to September 2019. A total of 52 PCOS patients aged 18 to 40 years were included in this trial, which followed Rotterdam criteria. After providing written and consent form, individuals were randomized into one of the two groups and received Metformin 500 mg TD (n = 26) or Metformin Combination (n = 26). Results: After three months of treatment, both groups improved in terms of menstrual cycle irregularity and TSH levels, but the combination treatment improved the most. Conclusion: Probiotics may be considered in conjunction with Metformin for improving TSH levels to achieve better results.

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Relationship between TSH, T4, T3 and Prolactin in overweight and lean Sudanese PCOS Patients

Cited by 6 publications

References 29 publications

Assessment of Thyroid Functions Test among Hyperprolactinemic Sudanese Infertile Females

Assessment of Thyroid Functions Test among Hyperprolactinemic Sudanese Infertile Females

MANAGEMENT OF ENDOCRINE DISEASE: The impact of subclinical hypothyroidism on anthropometric characteristics, lipid, glucose and hormonal profile of PCOS patients: a systematic review and meta-analysis

Effect of Metformin and Its Combination with Probiotic on Menstrual Irregularity and TSH Levels in Patients with Polycystic Ovarian Syndrome: A Randomized Controlled Trial

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