Relationship between true fasting plasma insulin level and angiographic characteristics of coronary atherosclerosis

Abstract

SummaryBackground: Reports about the relationships between specific insulin concentration and coronary heart disease risk are controversial.Hypothesis: The objective of this study was to examine the association between insulin level and the severity of coronary atherosclerosis.Methods: The study population consisted of 507 consecutive patients (376 men and 131 women) who underwent coronary angiography for suspected or known coronary atherosclerosis. The patients' habits of smoking and drinking were investigated, and anthropometric measurements including body mass index, systolic and diastolic blood pressures, as well as plasma measurements including lipids and blood glucose were taken. The true insulin level was measured using a highly sensitive two-site sandwich ELISA. The severity of coronary atherosclerosis was defined by the Gensini score system. The statistical methods including Kruskal-Wallis test, chi-square analysis, Spearman correlation analysis, and multivariate stepwise linear regression analysis were employed to explore the relationship between specific insulin level and coronary atherosclerosis.Results: When the Gensini score was examined as a categorical variable classified by tertile values, subjects with a high

The Polymorphism in Acetaldehyde Dehydrogenase 2 Gene, Causing a Substitution of Glu > Lys504, Is Not Associated with Coronary Atherosclerosis Severity in Han Chinese

“…According to the number of lesioned arteries, there were three ranks, namely, 1 lesioned artery, 2 lesioned arteries, and 3 lesioned arteries; (2) Gensini score: 1-25%, 26-50%, 51-75%, 76-90%, 91-99%, and 100% of coronary luminal narrowing were given scores of 1, 2, 4, 8, 16, and 32, respectively. This score was then multiplied by a factor based on the importance of lesion's position in the coronary arterial tree: 5 for the left main coronary artery, 2.5 for proximal segment of the left anterior descending coronary artery (LAD) or the circumfl ex artery (LCX), 1.5 for mid-segment of the LAD, 1 for distal segment of the LAD or mid-distal of LCX or right coronary artery, and 0.5 for others (Gensini 1983;Jia et al 2006). …”

Prevalence of Undiagnosed Type 2 Diabetes Mellitus in Acute ST Elevation Myocardial Infarction

“…This factor may in turn cause a sudden drop in fasting insulin in response to stress thus rendering our correlation analysis to become falsely insigni cant. Other than that, Jia et al demonstrated signi cant correlations between insulin levels and severity of CAD but the multivariate analysis did not indicate that insulin levels are predictors for the severity of CAD [10]. The inconsistent ndings regarding the correlation between insulin levels and CAD severity, as evidenced by previous literature suggest that insulin levels may not be a de nitive predictor or reliable marker for assessing severity of CAD [10][11][12].…”