Relationship between triglyceride–glucose index and carotid plaques in a high-stroke-risk population in southeast china: A population-based cross-sectional survey

Abstract

BackgroundCervical arterial atherosclerosis (CAA) is an important risk factor of stroke in China. The triglyceride–glucose (TyG) index is a simple and low-cost marker for ischemic stroke. Whether the TyG index predicts cervical arterial atherosclerosis remains uncertain. This study aimed to investigate the relationship between the TyG index and cervical arterial atherosclerosis.MethodsThis cross-sectional study was conducted in residents aged ≥40 years in the general population of southeast China. All participants completed a detailed questionnaire and provided blood samples. The high-stroke-risk groups further completed cervical artery ultrasonography. The TyG index was calculated using a well-established formula and analyzed in quartiles (Q1–Q4). Multivariate logistic regression was used to investigate the relationship between the TyG index and cervical arterial atherosclerosis.ResultsA total of 4,499 participants aged ≥40 years were finally included, with 23.47% comprising the high-stroke-risk population. The prevalence rates of increased intima–media thickness (IMT), carotid plaque, and cervical artery stenosis (CAS) in the high-stroke-risk population were 21.97%, 39.3%, and 6.1%, respectively. Subjects with higher TyG were still more likely to have carotid plaque. After adjusting for several established risk factors, compared with the TyG-Q1 group, the TyG-Q2, TyG-Q3, and TyG-Q4 groups were more likely to have carotid plaque (OR = 1.85, 95%CI = 1.28–2.67; OR = 1.51, 95%CI = 1.05–2.18; and OR = 1.29, 95%CI = 0.90–1.84). TyG was an independent predictor of the presence of plaque in the carotid artery of the high-stroke-risk population.ConclusionsAn elevated TyG index is a potential predictor of carotid plaques in the high-stroke-risk population older than 40 years.

The atherogenic index of plasma and carotid atherosclerosis in a community population: a population-based cohort study in China

“…Subjects with at least three of these risk factors were classified into the high-risk stroke population, while the participants with less than 3 risk factors but having one of the following medical histories: diabetes, hypertension, and atrial fibrillation were defined as medium-risk group. Low risk of stroke was defined as having < 3 risk factors and without diabetes, hypertension, and atrial fibrillation [ 30 ]. The atherogenic index of plasma (AIP) was defined as the logarithm to the base 10 of the ratio of fasting plasma triglyceride (TG) (mg/dL) to high-density lipoprotein cholesterol (HDL-C) [log (TG/HDL-C)] [ 20 , 31 ].…”

The role of triglyceride-glucose index in the differential diagnosis of atherosclerotic stroke and cardiogenic stroke

“…Additionally, one of our previous studies has found that the TyG index is an independent predictor of carotid plaque formation in people over 40 years of age at high risk of stroke [18]. TyG index is closely related to stroke, particularly LAA.…”