Relationship between trace elements and premature hair graying

Priya, Ramya; Kalawat, TC; Kadiyala, Silpa; Manthri, Ranadheer Gupta; Rukmangadha, Nandyala; Kumar, Siva

doi:10.4103/ijot.ijot_8_18

Cited by 10 publications

(1 citation statement)

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“…Nutritional deficiencies, including lower levels of vitamin B12, copper, iron, calcium, and vitamin D3, are also thought to play a role in PGH through the modulation of various metabolic processes [7]. For example, it is proposed that iron modulates tyrosinase activity as the enzyme dopachrome tautomerase, which is responsible for a later stage of melanin biosynthesis, is a metalloenzyme that utilizes ferrous, a form of iron, in its active site [8]. Sharma and Dogra found that patients with PGH reported a significantly higher incidence of atopic diathesis and a sedentary lifestyle, as well as significantly lower levels of high-density lipoprotein (HDL)-cholesterol [9].…”

Section: Table 1: Summary Of Hair Characteristics By Ethnicitymentioning

confidence: 99%

Fractal Pattern in the Premature Graying of Hair: A Case Report

Phan,

Ali,

Black

et al. 2024

Cureus

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Premature graying of hair (PGH) is a multifactorial condition defined by the graying of hair before the age of 20 in Caucasians and before the age of 30 in African Americans. Although the etiology remains unknown, it has been associated with genetic predisposition, oxidative stress, nutritional deficiencies, and autoimmune diseases. Current treatment options are limited but can include anti-inflammatory medications, vitamins, and hair colorants for symptom control. In this report, we present a case of premature graying in a 32-yearold male, onset at age 15, exhibiting a distinctive fractal pattern. This case represents a unique instance of PGH characterized by an unusual pattern, necessitating further investigation into potential etiological factors and underlying pathophysiological mechanisms.

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Section: Table 1: Summary Of Hair Characteristics By Ethnicitymentioning

confidence: 99%

Fractal Pattern in the Premature Graying of Hair: A Case Report

Phan,

Ali,

Black

et al. 2024

Cureus

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Clinical and epidemiological characteristics and associated factors of hair graying: a population-based, cross-sectional study in Turkey

Acer

Arslantaş

Emiral

et al. 2020

Anais Brasileiros de Dermatologia

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Exploration of potential lipid biomarkers for premature canities by UPLC‐QTOF‐MS analyses of hair follicle roots

Wang

He³

2020

Experimental Dermatology

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Background The rate of premature greying, referred to as canities, varies among populations, and effective treatments are lacking. However, few studies at the molecular level have been reported. Objectives Comparing lipid profiles of individuals with premature canities and healthy volunteers to explore the mechanism of premature canities. Methods Ultra‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry (UPLC‐QTOF‐MS) was used to detect lipids in the hair follicle root. Multivariate data analysis was used to show lipid changes in follicle roots. Results We identified lipids in the hair follicle root that differ between black and white hair and analysed key lipids contributing to white hair development. We divided the samples into three groups: PC‐WH (Premature canities‐White hair), PC‐PH (Premature canities‐Pigmented hair), Control‐PH (Pigmented hair). Phosphatidylethanolamine (PE), phosphatidylcholine (PC), vitamin D3 (VD3) and cholesterol in Control‐PH were higher than those in PC‐WH. Sphingomyelin (SP), phosphatidic acid (PA), VD3 and diglyceride (DG) were lower in PC‐WH than in PC‐PH. Levels of VD3 were highest in Control‐PH, gradually decreased as the severity of PC‐PH increased and were lowest in PC‐WH. Conclusion There are 7 main class candidate compounds involved in the generation of white hair. VD3 showed a substantial decrease in white hair and was a potential target for further studies of premature canities.

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Relationship between trace elements and premature hair graying

Cited by 10 publications

References 0 publications

Fractal Pattern in the Premature Graying of Hair: A Case Report

Fractal Pattern in the Premature Graying of Hair: A Case Report

Clinical and epidemiological characteristics and associated factors of hair graying: a population-based, cross-sectional study in Turkey

Exploration of potential lipid biomarkers for premature canities by UPLC‐QTOF‐MS analyses of hair follicle roots

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