Relationship Between Total Tear IgE and Specific Serum IgE in Autumnal Allergic Conjunctivitis

Mimura, Tatsuya; Usui, Tomohiro; Yamagami, Satoru; Miyai, Takashi; Amano, Shiro

doi:10.1097/ico.0b013e318253214b

Cited by 19 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, the mean total tear IgE level (for those with detectable levels) in our population was 0.363 IU/mL (0.873 ng/mL), which is higher than prior reports from healthy controls (0.058 IU/mL; 95% CI 0.012–0.287), but lower than what has been reported in patients with AC (5.259 IU/mL; 95% CI 0.053–523.219) [24,31,32,33]. This is not surprising, as none of our subjects had a diagnosis of AC, but points to a possible subclinical component of allergy in a portion of our patients.…”

Section: Discussioncontrasting

confidence: 75%

Total Tear IgE Levels Correlate with Allergenic and Irritating Environmental Exposures in Individuals with Dry Eye

Dermer

Theotoka

Lee

et al. 2019

JCM

View full text Add to dashboard Cite

Dry eye (DE) and allergic conjunctivitis may present similarly, and it remains unclear whether some individuals have an underlying allergic component to their DE. To better understand this relationship, we performed a cross-sectional study in 75 individuals with DE symptoms and/or signs. Immunoglobulin E (IgE) levels in tear samples were quantified and home environmental exposures assessed via standardized survey. Tears were collected by Schirmer strip, and total tear IgE levels were quantified using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using descriptive statistics and linear and logistic regressions. The main outcome measures were total tear IgE levels and their association with environmental exposures. The mean age of the subjects was 66.2 ± 7.8 years. Sixty-two individuals had dry eye symptoms (Dry Eye Questionnaire-5 ≥ 6), and 75 had one or more signs of DE. Detectable total tear IgE levels were observed in 76% of subjects, and 17.3% had high levels (>1 ng/mL). Individuals with exposure to pet(s) (odds ratio (OR) 11.5, p = 0.002) and smoke (OR 38.6, p = 0.008) at home were more likely to have high IgE levels compared to those not exposed. Individuals with tears collected during spring or summer were 3.9 times (p = 0.028) more likely to have high IgE compared to those sampled at other times of year. Subjects born in the US were 3.45 times (p = 0.010) more likely to have high IgE compared to individuals born outside the US. To conclude, a majority of individuals with DE symptoms and/or signs had detectable IgE levels in their tears. High tear IgE levels were correlated with allergy season and exposures in the home linked with allergy.

show abstract

Section: Discussioncontrasting

confidence: 75%

Total Tear IgE Levels Correlate with Allergenic and Irritating Environmental Exposures in Individuals with Dry Eye

Dermer

Theotoka

Lee

et al. 2019

JCM

View full text Add to dashboard Cite

show abstract

“…The number of patients was significantly correlated with the level of SPM in winter (r = 0.70), but there was no relationship in spring (r = 0.53), summer (r = 0.01), or autumn (r = 0.20) (Table 2). One possible reason is that atmospheric pollen levels increase during spring and autumn in Japan as pollen is released from the forests twice per year [44][45][46][47][48], while house dust mites and mold are the main causes of seasonal allergy in the humid summer and autumn months. Because our study did not assess outdoor allergens such as pollen and mites, our results might have been influenced by airborne allergens (pollen and mites) as well as air pollutants during spring, summer, and autumn.…”

Section: Discussionmentioning

confidence: 99%

Airborne Suspended Particulate Matter and the Prevalence of Allergic Conjunctivitis in Japan

Mimura,

Ichinose,

Inoue

et al. 2024

Cureus

Self Cite

View full text Add to dashboard Cite

BackgroundThis study aimed to examine the association of suspended particulate matter (SPM) with outpatient attendance for allergic conjunctivitis. MethodologyThe information on air pollution, encompassing total hydrocarbons, non-methane hydrocarbons, methane, carbon monoxide, nitrogen oxide, nitric oxide, oxidants, and SPM alongside data concerning daily weather conditions such as temperature, wind speed, and humidity, was gathered. Subsequently, the weekly mean values for outpatient visits, air pollution, and weather parameters were computed. ResultsThe number of outpatient visits for allergic conjunctivitis was significantly associated with SPM levels (r = 0.70, p = 0.0037), oxidant levels (r = 0.70, p = 0.0038), wind speed (r = 0.48, p = 0.0472), and humidity (r = 0.77, p = 0.0009) from January to March, as well as SPM levels (r = 0.53, p = 0.0309) and carbon monoxide (r = 0.56, p = 0.0230) from April to June. Multivariate analysis showed that SPM (odds ratio = 1.37, p = 0.0161) and wind velocity (odds ratio = 1.52, p = 0.0038) were significant predictors of the number of outpatient visits from January to December. ConclusionsSPM levels were the only independent predictor of outpatient visits for allergic conjunctivitis, suggesting that SPM contributes to the pathophysiology of this condition.

show abstract

“…A commercial kit, Allerwatch® Tear IgE [12][13][14][15], that measures total IgE antibody levels in lachrymal fluids has recently become available, and it confirms the local production of IgE antibodies in the eye.…”

Section: Discussionmentioning

confidence: 99%

Relationship among total tear IgE, specific serum IgE, and total serum IgE levels in patients with pollen-induced allergic conjunctivitis

Yamana¹,

Yamana

Uchio

2021

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Background Recently, the number of patients with pollinosis, particularly Japanese cedar pollinosis, has markedly increased. We previously reported about local allergic conjunctivitis, which is a phenotype of allergic conjunctivitis (AC). AC cases are often sensitized by various antigens. This study aimed to investigate the relationship among total tear IgE (t-tIgE), specific serum IgE (s-sIgE), and total serum IgE (t-sIgE) levels in patients with pollen-induced AC. Methods In 2019, 1372 patients were clinically diagnosed with AC at the Yamana Eye Clinic using t-tIgE, t-sIgE, and s-sIgE tests against 39 allergens. Among the pollen-induced AC patients who underwent allergen testing, 99 tested positives for s-sIgE against pollen. The subjects comprised 33 (33.3%) male and 66 (66.7%) female individuals aged 9–86 years. Results The t-tIgE test was positive in 68 (68.7%) patients and negative in 31 (31.3%) patients. In the t-sIgE test, 45 (45.5%) patients had t-sIgE levels above the reference value of 170 IU/mL. The higher the total score of the positive class value of each pollen-specific IgE (pollen-sIgE) antibody, the higher the positive rate of t-tIgE (p < 0.001). Of 32 patients in whom food-specific IgE (food-sIgE) was detected, 81.3% of the pollen-sIgE-positive and food-sIgE-positive cases were also positive for t-sIgE and t-tIgE. However, significant difference was not found between the total score of food-sIgE of the t-tIgE positive group and negative group. Conclusions Pollen-induced AC is caused by pollen sensitization of the conjunctiva. Food-induced AC might be induced by the different pathological mechanism involved in pollen-induced AC.

show abstract

Relationship Between Total Tear IgE and Specific Serum IgE in Autumnal Allergic Conjunctivitis

Cited by 19 publications

References 16 publications

Total Tear IgE Levels Correlate with Allergenic and Irritating Environmental Exposures in Individuals with Dry Eye

Total Tear IgE Levels Correlate with Allergenic and Irritating Environmental Exposures in Individuals with Dry Eye

Airborne Suspended Particulate Matter and the Prevalence of Allergic Conjunctivitis in Japan

Relationship among total tear IgE, specific serum IgE, and total serum IgE levels in patients with pollen-induced allergic conjunctivitis

Contact Info

Product

Resources

About