Relationship between toll-like receptor 2 Arg677Trp and Arg753Gln and toll-like receptor 4 Asp299Gly polymorphisms and cytomegalovirus infection

Jabłońska, Agnieszka; Paradowska, Edyta; Studzińska, Mirosława; Suski, Patrycja; Nowakowska, Dorota; Wiśniewska-Ligier, Małgorzata; Woźniakowska-Gęsicka, Teresa; Wilczyński, J; Leśnikowski, Zbigniew J.

doi:10.1016/j.ijid.2014.04.001

Cited by 33 publications

(43 citation statements)

References 45 publications

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“…We could not confirm that the present HTX patients had a lower rate of CMV-seropositivity associated with the TLR2 R753Q polymorphism before transplantation, despite studying a comparably large cohort of patients [12].…”

Section: Discussioncontrasting

confidence: 58%

“…The TLR2 R753Q polymorphism was proposed to partially protect from CMV infection as the mutated genotype was associated with a lower CMV-seroprevalence [12]. We could not confirm that the present HTX patients had a lower rate of CMV-seropositivity associated with the TLR2 R753Q polymorphism before transplantation, despite studying a comparably large cohort of patients [12].…”

Section: Discussionmentioning

confidence: 57%

“…In contrast, the TLR R753Q polymorphism was not associated with an increased risk for CMV replication and disease in kidney transplant recipients [11]. Moreover, Jablonska et al observed a significantly lower frequency of heterozygosity for the TLR2 R753Q polymorphism in immunocompetent patients with primary CMV infection when compared to non-infected individuals [12]. This observation may even suggest a protective effect of the TLR2 R753Q polymorphism against CMV infection.…”

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

Clinical significance of the single nucleotide polymorphism TLR2 R753Q in heart transplant recipients at risk for cytomegalovirus disease

Schneider

Matiqi

Kundi

et al. 2016

Journal of Clinical Virology

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Clinical significance of the single nucleotide polymorphism TLR2 R753Q in heart transplant recipients at risk for cytomegalovirus disease

Schneider

Matiqi

Kundi

et al. 2016

Journal of Clinical Virology

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“…Other authors have reported that TLR polymorphisms or epigenetic changes in the methylation state of their gene promoter regions influence the duration and magnitude of the immune response to HCMV infection [163]. On the other hand, heterozygosity in TLR2 and TLR4 receptors diminishes the risk of infection by this virus in adults [164].…”

Section: Cytomegalovirusmentioning

confidence: 99%

The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability

Morris¹,

Berk

Walder

et al. 2015

Mol Neurobiol

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Patients who present with severe intractable apparently idiopathic fatigue accompanied by profound physical and or cognitive disability present a significant therapeutic challenge. The effect of psychological counseling is limited, with significant but very slight improvements in psychometric measures of fatigue and disability but no improvement on scientific measures of physical impairment compared to controls. Similarly, exercise regimes either produce significant, but practically unimportant, benefit or provoke symptom exacerbation. Many such patients are afforded the exclusionary, non-specific diagnosis of chronic fatigue syndrome if rudimentary testing fails to discover the cause of their symptoms. More sophisticated investigations often reveal the presence of a range of pathogens capable of establishing life-long infections with sophisticated immune evasion strategies, including Parvoviruses, HHV6, variants of Epstein-Barr, Cytomegalovirus, Mycoplasma, and Borrelia burgdorferi. Other patients have a history of chronic fungal or other biotoxin exposure. Herein, we explain the epigenetic factors that may render such individuals susceptible to the chronic pathology induced by such agents, how such agents induce pathology, and, indeed, how such pathology can persist and even amplify even when infections have cleared or when biotoxin exposure has ceased. The presence of active, reactivated, or even latent Herpes virus could be a potential source of intractable fatigue accompanied by profound physical and or cognitive disability in some patients, and the same may be true of persistent Parvovirus B12 and mycoplasma infection. A history of chronic mold exposure is a feasible explanation for such symptoms, as is the presence of B. burgdorferi. The complex tropism, life cycles, genetic variability, and low titer of many of these pathogens makes their detection in blood a challenge. Examination of lymphoid tissue or CSF in such circumstances may be warranted.

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“…Therefore, donor SNPs in CCR5 gene may modulate the dynamics of CMV replication in allo-HSCT recipients. Other authors have found that heterozygosity for the tolllike receptor (TLR)2 and TLR4 SNPs was associated with lower risk of CMV infection and lower level of viremia, respectively [98] and, therefore, those polymorphisms appear to be protective factors in CMV replication. Saadi and colleagues found association between gene polymorphisms of co-stimulatory molecules and active CMV infection in HSCT recipients [99].…”

Section: Gene Polymorphismsmentioning

confidence: 99%

The immune response to cytomegalovirus in allogeneic hematopoietic stem cell transplant recipients

Ciáurriz

Zabalza

Beloki

et al. 2015

Cell. Mol. Life Sci.

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Approximately, up to 70 % of the human population is infected with cytomegalovirus (CMV) that persists for life in a latent state. In healthy people, CMV reactivation induces the expansion of CMV-specific T cells up to 10 % of the entire T cell repertoire. On the contrary, CMV infection is a major opportunistic viral pathogen that remains a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Due to the delayed CMV-specific immune recovery, the incidence of CMV reactivation during post-transplant period is very high. Several methods are currently available for the monitoring of CMV-specific responses that help in clinical monitoring. In this review, essential aspects in the immune recovery against CMV are discussed to improve the better understanding of the immune system relying on CMV infection and, thereby, helping the avoidance of CMV disease or reactivation following hematopoietic stem cell transplantation with severe consequences for the transplanted patients.

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Relationship between toll-like receptor 2 Arg677Trp and Arg753Gln and toll-like receptor 4 Asp299Gly polymorphisms and cytomegalovirus infection

Abstract: Our results suggest that the wild-type TLR2 genotype may be a risk factor for CMV replication in adult patients.

Cited by 33 publications

References 45 publications

Clinical significance of the single nucleotide polymorphism TLR2 R753Q in heart transplant recipients at risk for cytomegalovirus disease

Clinical significance of the single nucleotide polymorphism TLR2 R753Q in heart transplant recipients at risk for cytomegalovirus disease

The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability

The immune response to cytomegalovirus in allogeneic hematopoietic stem cell transplant recipients

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