Relationship between time-dependent variability in cardiometabolic risk factors and biochemical markers with cytokine and adipokine levels in hemodialysis patients

Ribeiro, Anderson Castro; Silva, Robson Eugênio; Justino, Patrícia B I; Santos, Eliziária Cardoso dos; Gonçalves, Reggiani Vilela; Novaes, Rômulo Dias

doi:10.1016/j.cyto.2022.155802

Cited by 4 publications

(1 citation statement)

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“…Thus, we assume that IL-6 is a cytokine which is mostly linked to RRT duration per se and does not relate to body composition parameters a lot. In available literature, a time-dependent increase in IL-6 serum levels of HD patients was also seen [28][29][30].…”

Section: Discussionmentioning

confidence: 93%

Malnutrition and Erythropoietin Resistance among Patients with End-Stage Kidney Disease: Where Is the Perpetrator of Disaster?

et al. 2022

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Background: Hemodialyzed patients with poor erythropoietin response tend to have low volume of visceral adipose tissue and score high on malnutrition-inflammation score. This study investigates in-depth the role of leptin and chosen cytokines in the development of malnutrition-inflammation syndrome (MIS) and erythropoietin resistance. Methods: Eighty-one hemodialyzed patients with erythropoietin-treated anemia were enrolled in the study. Their body composition was measured. Erythropoietin resistance index was calculated. Blood samples for leptin, IL-6, IL-18, TNF-alpha, and IL-1-alpha serum levels were drawn. Results: Leptin showed negative correlation with erythropoietin resistance index (ERI), whilst IL-6 showed the opposite. IL-6 seemed to be linked more to HD parameters and vintage, while TNF-alpha and leptin were more dependent on body composition. IL-18 and IL-1-alpha did not affect nutritional parameters nor ERI. Conclusion: Modulation of adipokine- and cytokine-related signaling is a promising target in tempering malnutrition in hemodialyzed, and thus achieving better outcomes in anemia treatment. Large clinical studies that target the inflammatory response in hemodialysis, especially regarding IL-6, TNF-alpha, and leptin, would be of great worth.

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Section: Discussionmentioning

confidence: 93%