Relationship between thyroid function and ICU mortality (sick euthyroid syndrome)

Bose, Priyadarsini; Dasarathan, Ramesh; Murugesan, Arun Shivaraman Mulaur; Chenthil, K S

doi:10.18203/2349-3933.ijam20173662

Cited by 2 publications

(2 citation statements)

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“…The study concluded that FT3 and FT4 were lesser in non-survivors as compared to survivors with significant difference and FT3 and FT4 were best independent predictors of ICU mortality. Similar relationship between thyroid function abnormalities and mortality was also reported by the authors such as Wang et al [18] and Bose et al [19].…”

Section: Discussionsupporting

confidence: 86%

Thyroid Function Abnormalities in Patients Admitted in Medical Intensive Care Unit

Kumar¹,

SHIVAPRASAD²,

NAGAJYOTHI³

2023

Asian J Pharm Clin Res

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Aims and Objectives: The aim of the study was to assess the thyroid hormone levels in patients admitted in intensive care unit (ICU) for various critical medical conditions. Methods: This was a prospective and observational study conducted in the department of medicine of a tertiary care medical college. One hundred and twenty patients admitted in medical ICU for various medical conditions were included in this study on the basis of a predefined inclusion and exclusion criteria. A detailed history with respect to demographic details such as age, gender, and body mass index was noted. APACHE II score of the patients were noted with an objective to assess the severity of the illness. The incidence of thyroid function abnormalities as well as the analysis of patients’ outcome in terms of thyroid function abnormalities was determined. p<0.05 was taken as statistically significant. Results: Out of these 120 patients, there were 78 (65%) were males and 42 (35%) were females with a M: F ratio of 1:1.0.53. The mean age of patients was found to be 44.52±11.27 years. The most common indication for admission was diabetic ketoacidosis (23.33%) followed by stroke (15.00%) and renal failure (11.67%). Thyroid function abnormalities were seen in 26 (21.67%) patients. These abnormalities were seen in patients with diabetic ketoacidosis (4.17%), congestive cardiac failure (4.17%), stroke (3.33%), renal failure (2.50%), hypertensive crisis, and multiorgan dysfunction (2.50%). Mortality was found to be significantly high in patients having thyroid function abnormalities as compared to those who had normal thyroid function. Conclusion: Thyroid function abnormalities are common in patients admitted in ICU and are associated with adverse outcome.

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Section: Discussionsupporting

confidence: 86%

Thyroid Function Abnormalities in Patients Admitted in Medical Intensive Care Unit

Kumar¹,

SHIVAPRASAD²,

NAGAJYOTHI³

2023

Asian J Pharm Clin Res

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“…1 These alterations are correlated with the severity of morbidity and the outcomes of patients in ICU. 2 Thyroid hormones have a crucial role in adapting the metabolic functions during stress and critical illness. Patients who are critically ill may have profound changes in thyroid hormone metabolism.…”

Section: Introductionmentioning

confidence: 99%

Study of thyroid function in patients admitted in intensive care unit

Chintalapudi

Suresh

2022

Int J Res Med Sci

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Background: The thyroid gland produces two related hormones, tetraiodothyronine (T4) and triiodothyronine (T3) play a critical role in cell differentiation during development and maintain thermogenic and metabolic homeostasis in the adult. Critically ill patients have been defined as those that by dysfunction or failure of one or more organ system depend on survival from advanced instruments monitoring and therapy. The objective was to study the thyroid dysfunction in critically ill patients admitted in intensive care units and its relation to the mortality and severity of disease.Methods: This is a cross sectional study carried out in Dr. Pinnamaneni Siddhartha institute of medical sciences and research foundation, Chinoutpalli, Andhra Pradesh from 1st January 2022 to 30th September 2022 involving 100 patients. Patients of age above 18 years, both sexes, admitted to intensive care units with critical illness were analyzed and approved by institutional ethics committee of Dr. PSIMS and RF data were entered in MS-excel and analyzed in SPSS V22 software. Descriptive statistics, Mann-Whitney U test, logistic regression, ROC curves were applied. P values were reported for all statistical tests and a value of<0.05 was considered to be significant.Results: Out of 100 critically ill patients out of which 17 patients had sepsis, 18 had acute renal failure, 19 patients had acute respiratory failure, 19 patients had diabetic ketoacidosis, 16 patients had congestive cardiac failure, and 11 patients had stroke and their correlation with t3 hormone decrement showed positive correlation.Conclusions: Thyroid profile can be used in predicting the mortality in ICU patients.

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Relationship between thyroid function and ICU mortality (sick euthyroid syndrome)

Cited by 2 publications

References 4 publications

Thyroid Function Abnormalities in Patients Admitted in Medical Intensive Care Unit

Thyroid Function Abnormalities in Patients Admitted in Medical Intensive Care Unit

Study of thyroid function in patients admitted in intensive care unit

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