Relationship Between Thyroid Autoimmunity and Yersinia Enterocolitica Antibodies

Çorapçıoğlu, Demet; Tonyukuk, Vedia; Kıyan, Mehmet; Yilmaz, Arif E.; Emral, Rıfat; Kamel, Nurí; Erdoğan, Gürbüz

doi:10.1089/105072502320288483

Cited by 51 publications

(23 citation statements)

References 10 publications

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“…In Greece, 25% of Hashimoto patients had IgG antibodies and 2.8% had IgA antibodies, compared with 2 and 0% respectively in controls (196). A higher incidence of Y. enterocolitica antibodies in Graves and Hashimoto patients than in controls was also found in Japan and Turkey (197,198). However, there are also studies that could not confirm these findings and found a similar rate of seropositivity in AITD patients and controls (199,200).…”

Section: Y Enterocolitica Infectionmentioning

confidence: 98%

The environment and autoimmune thyroid diseases

2004

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Genetic factors play an important role in the pathogenesis of autoimmune thyroid disease (AITD) and it has been calculated that 80% of the susceptibility to develop Graves' disease is attributable to genes. The concordance rate for AITD among monozygotic twins is, however, well below 1 and environmental factors thus must play an important role. We have attempted to carry out a comprehensive review of all the environmental and hormonal risk factors thought to bring about AITD in genetically predisposed individuals. Low birth weight, iodine excess and deficiency, selenium deficiency, parity, oral contraceptive use, reproductive span, fetal microchimerism, stress, seasonal variation, allergy, smoking, radiation damage to the thyroid gland, viral and bacterial infections all play a role in the development of autoimmune thyroid disorders. The use of certain drugs (lithium, interferon-a, Campath-1H) also increases the risk of the development of autoimmunity against the thyroid gland. Further research is warranted into the importance of fetal microchimerism and of viral infections capable of mounting an endogenous interferon-a response.European Journal of Endocrinology 150 605-618

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Section: Y Enterocolitica Infectionmentioning

confidence: 98%

The environment and autoimmune thyroid diseases

2004

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“…Both genetic predisposition and cross-reactivity between antigens have been hypothesized as potential mechanisms for this association. A functional polymorphism in the protein tyrosine phosphatase gene, the PTPN22 620W allele has been recognized as a predisposing factor for several autoimmune disorders, including AITD, Wegener’s granulomatosis, and ANCA positivity (54–56). PTPN22 is located on chromosome 1p13.3–13.1.10 and encodes an 807-amino acid protein that interacts with Csk, a tyrosine kinase that is involved in the intracellular signaling cascade following T-cell activation.…”

Section: Glomerular Disease Related To Aitmentioning

confidence: 99%

Autoimmune Thyroiditis and Glomerulopathies

et al. 2017

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Autoimmune thyroiditis (AIT) is generally associated with hypothyroidism. It affects ~2% of the female population and 0.2% of the male population. The evidence of thyroid function- and thyroid autoantibody-unrelated microproteinuria in almost half of patients with AIT and sometimes heavy proteinuria as in the nephrotic syndrome point to a link of AIT with renal disease. The most common renal diseases observed in AIT are membranous nephropathy, membranoproliferative glomerulonephritis, minimal change disease, IgA nephropathy, focal segmental glomerulosclerosis, antineutrophil cytoplasmic autoantibody (ANCA) vasculitis, and amyloidosis. Different hypotheses have been put forward regarding the relationship between AIT and glomerulopathies, and several potential mechanisms for this association have been considered. Glomerular deposition of immunocomplexes of thyroglobulin and autoantibodies as well as the impaired immune tolerance for megalin (a thyrotropin-regulated glycoprotein expressed on thyroid cells) are the most probable mechanisms. Cross-reactivity between antigens in the setting of genetic predisposition has been considered as a potential mechanism that links the described association between ANCA vasculitis and AIT.

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“…Its success in treating CDI sparked interest in investigating FMT as a treatment for other medical conditions associated with intestinal dysbiosis, such as ulcerative colitis [9–11], Crohn’s disease (CD) [12–14], irritable bowel syndrome (IBS) [15, 16], and others, including metabolic syndrome [17], neurodevelopmental [18], and autoimmune disorders [19]. Despite the excitement due to its therapeutic potential, FMT also presents challenges for researchers and clinicians with potential adverse outcomes, including the transfer of infectious organisms [20] or contaminants from the environment [21, 22].…”

Section: Introductionmentioning

confidence: 99%

Tracking microbial colonization in fecal microbiota transplantation experiments via genome-resolved metagenomics

et al. 2017

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BackgroundFecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection and shows promise for treating other medical conditions associated with intestinal dysbioses. However, we lack a sufficient understanding of which microbial populations successfully colonize the recipient gut, and the widely used approaches to study the microbial ecology of FMT experiments fail to provide enough resolution to identify populations that are likely responsible for FMT-derived benefits.MethodsWe used shotgun metagenomics together with assembly and binning strategies to reconstruct metagenome-assembled genomes (MAGs) from fecal samples of a single FMT donor. We then used metagenomic mapping to track the occurrence and distribution patterns of donor MAGs in two FMT recipients.ResultsOur analyses revealed that 22% of the 92 highly complete bacterial MAGs that we identified from the donor successfully colonized and remained abundant in two recipients for at least 8 weeks. Most MAGs with a high colonization rate belonged to the order Bacteroidales. The vast majority of those that lacked evidence of colonization belonged to the order Clostridiales, and colonization success was negatively correlated with the number of genes related to sporulation. Our analysis of 151 publicly available gut metagenomes showed that the donor MAGs that colonized both recipients were prevalent, and the ones that colonized neither were rare across the participants of the Human Microbiome Project. Although our dataset showed a link between taxonomy and the colonization ability of a given MAG, we also identified MAGs that belong to the same taxon with different colonization properties, highlighting the importance of an appropriate level of resolution to explore the functional basis of colonization and to identify targets for cultivation, hypothesis generation, and testing in model systems.ConclusionsThe analytical strategy adopted in our study can provide genomic insights into bacterial populations that may be critical to the efficacy of FMT due to their success in gut colonization and metabolic properties, and guide cultivation efforts to investigate mechanistic underpinnings of this procedure beyond associations.Electronic supplementary materialThe online version of this article (doi:10.1186/s40168-017-0270-x) contains supplementary material, which is available to authorized users.

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Relationship Between Thyroid Autoimmunity and Yersinia Enterocolitica Antibodies

Cited by 51 publications

References 10 publications

The environment and autoimmune thyroid diseases

The environment and autoimmune thyroid diseases

Autoimmune Thyroiditis and Glomerulopathies

Tracking microbial colonization in fecal microbiota transplantation experiments via genome-resolved metagenomics

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