Relationship between the striatal regulation of the temporal organization of behavior and the state of beta-adrenergic mechanisms

Arushanyan, É. B.; Beyer, Eduard; Shchetinin, Evgeny

doi:10.1007/bf02359496

Cited by 1 publication

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“…It had been known for some time that bilateral striatectomy disorganized the rhythmical structure of forced swimming and circadian motility of rats [57]. In an animal model of Parkinson's disease induced by bilateral striatal injection of 6-hydroxydopamine, significant decreases of mesor and phase advances of rhythms were reported [58].…”

Section: Discussionmentioning

confidence: 99%

Effect of Aging on 24-Hour Changes in Dopamine and Serotonin Turnover and Amino Acid and Somatostatin Contents of Rat Corpus striatum

et al. 2002

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This study examined the 24-hour changes in a number of transmitters in the corpus striatum of young and middle-aged male Wistar rats. The contents of excitatory amino acids (glutamate, aspartate) and inhibitory amino acids (γ-aminobutyric acid, GABA; taurine, glycine) and of somatostatin were measured in 2-month- and 18- to 20-month-old rats killed at six different time points along the 24-hour cycle. The striatal serotonin and dopamine turnover was also measured. Both young and middle-aged rats showed significant 24-hour variations in striatal glutamate and aspartate contents; only in young rats these variations fitted a cosine function, with acrophase during the first part of rest span. Mesor values of striatal excitatory amino acid contents were lowest in middle-aged rats. Significant 24-hour variations in striatal contents of GABA, taurine, and glycine occurred in young rats, while only striatal GABA exhibited 24-hour changes in middle- aged rats (acrophases during the first part of rest span). For every inhibitory transmitter, the mesor values in middle-aged rats were significantly lower than in young rats. The 24-hour variation of the striatal somatostatin content showed acrophase during the first part of rest span, mesor values and amplitude being lowest in middle-aged rats. Aging rats exhibited significantly higher mesor values of striatal serotonin turnover (34% increase) and lower mesor values of dopamine turnover (69% decrease) than their younger counterparts. Some of the circadian modifications of motor function seen in aging rats could be related to the striatal transmitter changes reported herein.

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Section: Discussionmentioning

confidence: 99%