Relationship between the Size and Location of the Mass and Hilar and Mediastinal Lymph Node Metastasis in Early and Locally Advanced Non-small Cell Lung Cancer

Kuzucuoğlu, Mustafa; Gökyer, Ali; Kula, Osman; Yekdeş, Ali Cem; Sunal, Baran Serdar; Karamustafaoğlu, Yekta Altemur; Yörük, Yener; Çiçin, İrfan

doi:10.29271/jcpsp.2020.02.172

Cited by 6 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Upper lobe NSCLCs are more likely to metastasize to the mediastinal LN, which is the underlying theory for dedicated lung lymphadenectomy [10,23,24]. Our results also suggested that the pT stage was a risk factor for station 4R metastasis, which was in agreement with other studies showing a relationship between tumor size and mediastinal LN metastasis [25,26]. Zhang et al suggested that systematic LN dissection should be performed, since tumor size was an independent risk factor for LN metastasis in patients even with pT1 stage lung adenocarcinoma [27].…”

Section: Discussionsupporting

confidence: 91%

Prognostic significance of 4R lymph node dissection in patients with right primary non-small cell lung cancer

et al. 2022

View full text Add to dashboard Cite

Background To investigate the prognostic significance of station 4R lymph node (LN) dissection in patients who underwent operations for right primary non-small cell lung cancer (NSCLC). Methods We performed a retrospective study involving patients with right primary NSCLC who received lobotomy or pneumonectomy with mediastinal LN dissection between January 2011 and December 2017. Propensity score matching was performed. Disease-free survival (DFS) and overall survival (OS) were compared between patients with and without station 4R dissection. Results Our study included 2070 patients, with 207 patients having no station 4R dissection (S4RD− group) and 1863 patients having station 4R dissection (S4RD+ group). The 4R LN metastasis rate was 13.4% (142/1748), higher than that for other mediastinal LN metastases. Compared with the S4RD− group, the S4RD+ group had higher 5-year DFS (48.1% vs. 39.1%, P = 0.009) and OS (54.4% vs. 42.8%, P = 0.025). Station 4R dissection was an independent risk factor for DFS (odds ratio, OR, 1.28, 95% confidence interval, CI, 1.08–1.64, P = 0.007) and OS (OR 1.31, 95% CI 1.04–1.63, P = 0.018). Patients with adjuvant chemotherapy had a better prognosis after station 4R dissection than those without adjuvant chemotherapy (57.4% vs. 52.3%, P = 0.006). The 5-year OS in the station 4R metastasis group was lower than that in the station 4R non-metastasis group (26.9% vs. 44.3%, P = 0.006) among N2 patients. The 5-year OS of the single-station 4R metastasis group was lower than that of the single-station 7 metastasis group (15.7% vs. 51.6%, P = 0.002). Conclusions Station 4R metastasis was the highest among all the mediastinal station metastases in right primary NSCLC patients. Station 4R dissection can improve the prognosis and should be recommended as a routine procedure for these patients.

show abstract

Section: Discussionsupporting

confidence: 91%

Prognostic significance of 4R lymph node dissection in patients with right primary non-small cell lung cancer

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The number and area of MLNM are closely related to the surgical method, resection range and postoperative recurrence. 16 At present, CT, bronchoscopy, mediastinoscopy and thoracoscopy are the methods for clinical diagnosis of MLNM. However, invasive surgery is not easily accepted by patients before definite diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical evaluation of contrast-enhanced CT combined with PET/CT in diagnosis of mediastinal lymph node metastasis of non-small-cell lung cancer

Li¹,

Zheng

Zhang³

et al. 2022

Pak J Med Sci

View full text Add to dashboard Cite

Objectives: To investigate the clinical value of contrast-enhanced CT combined with PET/CT in the differential diagnosis of mediastinal lymph node metastasis (MLNM) of non-small-cell lung cancer (NSCLC). Methods: A total of 120 patients with NSCLC combined with mediastinal lymphadenopathy hospitalized in our hospital were selected. All the patients received radical resection of lung cancer and mediastinal lymphadenectomy. After pathological diagnosis, they were divided into MLNM group (malignant group, undergoing contrast-enhanced CT) and non-MLNM group (benign group, receiving contrast-enhanced CT combined with PET-CT). The results were judged by two senior radiologists independently. The results of different scanning methods and postoperative pathology were compared using the t test, χ2 test and Pearson correlation coefficient test. Results: Compared with the pathological results, contrast-enhanced CT diagnosed 31 cases, with a coincidence rate of 62%, and contrast-enhanced CT combined with PET-CT diagnosed 42 cases, with a coincidence rate of 84%, presenting a statistically significant difference (P = 0.02). Among the 120 patients with lung cancer, pathological examination confirmed MLNM in 50 patients and benign enlargement in 70 patients, contrast-enhanced CT alone detected metastasis in 40 patients and benign enlargement in 80 patients, and contrast-enhanced CT combined with PET-CT detected metastasis in 47 patients and benign enlargement in 73 patients. The sensitivity and accuracy of the latter were significantly higher than those of the former (sensitivity, P = 0.01; accuracy, P = 0.01). With the increase in the malignancy of lymph nodes, the degree of CT enhancement, the concentration of radioactive substances and SUV value increased, showing positive correlations. Conclusion: Contrast-enhanced CT combined with PET/CT in the diagnosis of MLNM of NSCLC presents higher coincidence rate, sensitivity and accuracy. With the increase in tumor malignancy, the enhancement degree and radioactive substance concentration increase. The two methods are synergistic and complementary in diagnosing MLNM. doi: https://doi.org/10.12669/pjms.38.5.5528 How to cite this:Li X, Zheng X, Zhang T, Dong X, Su J. Clinical evaluation of contrast-enhanced CT combined with PET/CT in diagnosis of mediastinal lymph node metastasis of non-small-cell lung cancer. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5528 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

“…The lesion size is considered a critical predictor of the outcome in different types of cancers [ 18 , 19 , 20 ]. The increase in tumor size has been associated with mass-related complications like compression and hemorrhage, and with higher invasion and metastasis rates in cases of malignancies [ 20 , 21 ]. This will eventually result in more unfavorable management outcomes.…”

Section: Discussionmentioning

confidence: 99%

Isolated tectal cavernomas: A comprehensive literature review with a case presentation

Barbarawi

Asfour

Qudsieh

et al. 2022

Heliyon

View full text Add to dashboard Cite

Relationship between the Size and Location of the Mass and Hilar and Mediastinal Lymph Node Metastasis in Early and Locally Advanced Non-small Cell Lung Cancer

Cited by 6 publications

References 15 publications

Prognostic significance of 4R lymph node dissection in patients with right primary non-small cell lung cancer

Prognostic significance of 4R lymph node dissection in patients with right primary non-small cell lung cancer

Clinical evaluation of contrast-enhanced CT combined with PET/CT in diagnosis of mediastinal lymph node metastasis of non-small-cell lung cancer

Isolated tectal cavernomas: A comprehensive literature review with a case presentation

Contact Info

Product

Resources

About