Relationship between the precursors of high grade serous ovarian cancer and patient characteristics: decreased incidence of the p53 signature in pregnant women

Abstract

ObjectiveTo investigate the relationship between the precursors of high grade serous ovarian cancer (HGSOC) and the characteristics of patients with a low HGSOC risk in terms of the effects of pregnancy.MethodsWe prospectively examined consecutive cases in which the bilateral fallopian tubes were removed during benign gynecological or obstetric surgery and assessed the relationship between the patient characteristics, including parity and pregnancy, and the incidence of HGSOC precursors. All the fallopian tubes were examined by applying the Sectioning and Extensively Examining the Fimbriated End (SEE-FIM) Protocol.ResultsOf the 113 patients enrolled, 67 were gynecological and 46 were obstetric. The p53 signature was identified in 21 patients. No other precursors were identified. In a comparison of the p53 signature-positive and negative groups, parous women and pregnant women were significantly fewer in the p53 signature-positive group (53% vs. 86%, p=0.002, 10% vs. 47%, p=0.001, respectively). Current pregnancy was also associated with a significantly lower incidence of the p53 signature after multivariate adjustment (odds ratio [OR]=0.112; 95% confidence interval [95% CI]=0.017–0.731; p=0.022). Among gynecological patients, parous women were fewer in the p53 signature-positive group on univariate (47% vs. 73%, p=0.047) and multivariate analysis (OR=0.252; 95% CI=0.069–0.911; p=0.036). No other characteristics were associated with p53 signature positivity.ConclusionsThe incidence of the p53 signature was significantly lower in parous women and pregnant women. This decreased incidence of early phase serous carcinogenesis may be one of the possible mechanisms underlying HGSOC risk reduction among parous women.

Identification of AK4 as a novel therapeutic target for serous ovarian cancer

“…Ovarian cancer is asymptomatic in its early stages, and the rapid growth of ovarian cancer makes its diagnosis and treatment challenging ( 4 , 5 ). Serous ovarian cancer (SOC) is the main type of ovarian cancer, which progresses quickly, lacks effective treatment and is prone to bladder metastasis ( 6 ). At present, surgery supplemented by chemotherapy remains the main treatment option for advanced stages of SOC, and treatment outcomes are unsatisfactory ( 7 ).…”

Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

“…In total, 138 women who underwent BTL during S/C were included in this study. The mean age was 34.62 , the mean gravity was 4.89 (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), and the mean parity was 3.46 (1-10). In the extended period, which includes the study period (between 15 August 2020 and 31 December 2021), there were 4568 S/Cs, 643 BTLs, and 2 re-anastomoses in our institution.…”

“…Most of them are bilateral. Low-grade OSC is uncommon (<5% of all ovarian cancers) [10,12]. High and low-grade OSCs are said to have different carcinogenesis origins [13].…”

The role of non‐genomic actions of progesterone and its membrane receptor agonist in ovarian cancer cell death

“…9 Our group previously reported that the incidence of the p53 signature in fallopian tubes was significantly lower in pregnant and parous women. 10 Another report suggested that progesterone from follicular fluid during ovulation induces necroptosis in p53 mutated tubal epithelial cells and prevents carcinogenesis. 11 Progesterone may prevent early-phase serous carcinogenesis and suppress ovarian cancer cell growth.…”