Relationship between the neutrophil to high-density lipoprotein cholesterol ratio and severity of coronary artery disease in patients with stable coronary artery disease

Gao, Jie; Sha, Wenjun; Bin, Xu; Zhang, Cuiping; Wang, Hongping; Xia, Juan; Zhang, Hong; Tang, Wenjun; Tao, Ling

doi:10.3389/fcvm.2022.1015398

Cited by 8 publications

(7 citation statements)

References 49 publications

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“…Based on the Gensini score, the patients were divided into the negative (0, n = 46) and coronary artery lesion groups (> 0, n = 221). Based on the tertiles of the Gensini score, the patients in the coronary artery lesion group were further divided into mild lesion (≤ 8, n = 71), moderate lesion (8-23 points, n = 76), and severe lesion (≥ 23 points, n = 74) groups 13 .…”

Section: Methodsmentioning

confidence: 99%

Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis

Liu,

Chen,

et al. 2024

Int. J. Med. Sci.

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Background: Cleavage factor Im25 (CFIm25) regulates cell function by affecting mRNA editing processes and plays diverse roles in various diseases. Studies have found that peripheral blood monocytes are valuable in diagnosing and prognosing coronary atherosclerosis. However, no studies have examined the predictive value of CFIm25 expression in peripheral blood monocytes for coronary atherosclerosis. Methods and Results: We collected the coronary angiography results of 267 patients and calculated the Gensini score to evaluate their degree of coronary atherosclerosis. We isolated peripheral blood monocytes and detected CFIm25 RNA expression. Based on their Gensini score, we divided the patients into negative (0, n = 46), mild lesion (≤ 8, n = 71), moderate lesion (8-23, n = 76), and severe lesion (≥ 23, n = 74) groups. Results showed that CFIm25 expression correlated negatively with the Gensini score and the number of involved coronary vessels. Univariate and multivariate binary logistic regression analyses showed that CFIm25 expression in peripheral blood monocytes was a protective factor for severe lesions, ≥ 50% stenosis, and three-vessel lesions. The areas under the receiver operating characteristic curve of CFIm25 expression for predicting lesions, severe lesions, ≥50% stenosis, and three-vessel lesions were 0.743, 0.735, 0.791, and 0.736, respectively. Conclusions: CFIm25 expression in peripheral blood monocytes correlates negatively with the degree of coronary atherosclerosis and helps predict the severity and number of coronary artery lesions.

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Section: Methodsmentioning

confidence: 99%

Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis

Liu,

Chen,

et al. 2024

Int. J. Med. Sci.

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“…The patient's anthropometric and biochemical measurements were taken at admission. The height and weight were measured to calculate the body mass index (BMI) by using the formula weight/height 2 (kg/m 2 ) [ 24 ] while the patients were barefoot and in light clothing. The blood pressure was measured twice after the patient rested about 10 minutes and calculated the average value.…”

Section: Methodsmentioning

confidence: 99%

“…The blood pressure was measured twice after the patient rested about 10 minutes and calculated the average value. The fasting blood samples were taken for measurement of fasting insulin, fasting plasma glucose, lipid profiles, WBC, and monocyte automatically using a Beckman Coulter AU5800 biochemical analyzer (Brea, CA, USA) [ 24 ]. HOMA-IR was calculated by using the formula fasting plasma glucose multiplied by fasting insulin and then divided by 22.5.…”

Section: Methodsmentioning

confidence: 99%

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Association of Monocyte-to-HDL Cholesterol Ratio with Endothelial Dysfunction in Patients with Type 2 Diabetes

Zhang,

Lu,

Gao

et al. 2024

Journal of Diabetes Research

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Aims. To explore the relationship between monocyte-to-HDL cholesterol ratio (MHR) and endothelial function in patients with type 2 diabetes (T2DM). Methods. 243 patients diagnosed with T2DM were enrolled in this cross-sectional study. Patients were divided into two groups by flow-mediated dilation (FMD) quintile as nonendothelial dysfunction (FMD≥6.4%) and endothelial dysfunction (FMD<6.4%). The relationship between MHR and FMD was analyzed using Spearman’s correlation, partial correlation, and multiple logistic regression analysis. ROC curve was fitted to evaluate the ability of MHR to predict endothelial dysfunction. Results. Endothelial dysfunction was present in 193 (79%) patients. Patients with endothelial dysfunction had higher MHR (p<0.05) than those without endothelial dysfunction. Furthermore, MHR had a significantly positive correlation with endothelial dysfunction (r=0.17, p<0.05), and the positive association persisted even after controlling for confounding factors (r=0.14, p<0.05). Logistic regression showed that MHR was an independent contributor for endothelial dysfunction (OR: 1.35 (1.08, 1.70), p<0.05) and the risk of endothelial dysfunction increases by 61% with each standard deviation increase in MHR (OR: 1.61 (1.12, 2.30), p<0.05) (model 1). After adjusting for sex, age, BMI, disease course, hypertension, smoking, and drinking (model 2) as well as HbA1c, HOMA-IR, C-reactive protein, and TG (model 3), similar results were obtained. In ROC analysis, the area of under the ROC curve (AUC) for MHR was 0.60 (95% CI 0.52-0.69, p<0.05). Conclusion. MHR was independently associated with endothelial dysfunction in T2DM patients. It could be a new biomarker for vascular endothelial function assessment.

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“…Elevated NHR value is generally considered as an indicator of chronic in ammation and lipid metabolism disorder [19]. There have been several disorders that have been linked to NHR, such as coronary heart disease [20], diabetes [21], mental illness [22], and…”

Section: Introductionmentioning

confidence: 99%

Association of neutrophil-to-high-density lipoprotein cholesterol ratio with nonalcoholic fatty liver disease and liver fibrosis: a nationally representative cross-sectional study by NHANES from 2017 to 2020

Lu,

Xu,

et al. 2024

Preprint

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Background The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) has emerged as a promising biomarker reflecting inflammation and lipid dysregulation. Mounting evidence indicates that these metabolic disturbances play a pivotal role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). This study aims to elucidate the interplay among NHR, NAFLD, and liver fibrosis. Methods This cross-sectional investigation utilized data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES). Weighted multivariate logistic regression models were applied to explore the association between NHR and both NAFLD and liver fibrosis. Smoothed curve fitting and threshold effect analysis were conducted to uncover potential nonlinear relationships. Subgroup analyses were conducted to assess the consistency of these associations across different groups. Results The study encompassed 4602 participants. Our results demonstrated a significant positive association between NHR and NAFLD (OR = 1.09, 95% CI: 1.01–1.18). However, no significant association was found between NHR and liver fibrosis (OR = 1.02; 95% CI: 0.96–1.09). The analysis of smoothed curve fitting and threshold effect indicated an inverted U-shaped relationship between NHR and NAFLD, with a turning point at 5.92. Conclusion Our findings highlight a positive correlation between elevated NHR levels and NAFLD prevalence. However, no significant association was observed between NHR and liver fibrosis prevalence. Further prospective research is warranted to verify these results in a longitudinal setting.

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Relationship between the neutrophil to high-density lipoprotein cholesterol ratio and severity of coronary artery disease in patients with stable coronary artery disease

Cited by 8 publications

References 49 publications

Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis

Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis

Association of Monocyte-to-HDL Cholesterol Ratio with Endothelial Dysfunction in Patients with Type 2 Diabetes

Association of neutrophil-to-high-density lipoprotein cholesterol ratio with nonalcoholic fatty liver disease and liver fibrosis: a nationally representative cross-sectional study by NHANES from 2017 to 2020

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