Relationship between the &lt;b&gt;&lt;i&gt;FTO&lt;/i&gt;&lt;/b&gt; Genotype and Early Chronic Kidney Disease in Type 2 Diabetes: The Mediating Role of Central Obesity, Hypertension, and High Albuminuria

Marchetti, Júlia Rossetto; Balbino, Karla Pereira; Hermsdorff, Helen Hermana Miranda; Juvanhol, Leidjaira Lopes; Martínéz, J. Alfredo; Steemburgo, Thais

doi:10.1159/000516118

Cited by 4 publications

(2 citation statements)

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“…It is a global public health problem that has a ected more than 230 million people worldwide. Diabetes is expected to a ect the lives of about 10% of the population by 2030 [5][6][7]. e double blow of hypertension and diabetes to the kidney greatly increases the probability of renal function damage.…”

Section: Introductionmentioning

confidence: 99%

The Effect of TCM Syndrome Type and Western Medicine Detection on Patients with Hypertension and Diabetes Mellitus

Chen

Zhang

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the clinical changes of TCM syndrome type and microalbuminuria in patients with hypertension and diabetes mellitus. Methods. A total of 442 patients with hypertension and diabetes who were admitted to our hospital from June 2016 to June 2021 were selected. All patients were divided into medication group and control group according to the random number method. Patients in the medication group were treated with conventional Western medicine-assisted traditional Chinese medicine, while patients in the control group were not treated with adjuvant medicine. The blood pressure and blood glucose of patients in the two groups were controlled within the normal range, and the clinical effects of the two groups were observed. Results. The treatment of hypertension and diabetes in the two groups was diagnosed by the TCM syndrome type, and the cure rate was higher in the medication group. After 3 months, the glomerular filtration rate in the medication group increased steadily and the renal artery resistance index decreased, while the indexes in the control group had no significant change, with statistical significance ( P < 0.05 ). After 6 months, the urinary albumin excretion rate and the ratio of urinary albumin to creatinine in the medication group were significantly decreased compared with those before medication, while there were no significant changes in the control group, with statistical significance ( P < 0.05 ). The urine excretion rate of albumin in hypertensive patients with diabetes is higher, leading to the increased probability of microalbuminuria in patients, which is not only related to the course of hypertension and diabetes but also positively related to the course of hypertension and diabetes, smoking, drinking, and diet. Conclusion. The combination of the TCM syndrome type and Western medicine detection method is more conducive to the two diagnosis and treatment methods that complement each other, improve each other, improve the effect of diagnosis and treatment, and are worthy of further research by researchers, so as to promote clinical application. Some other bad habits should also be corrected, such as smoking, drinking, and irregular diet, through adjusting the diet; control of high protein intake is also an important intervention measure for disease.

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Section: Introductionmentioning

confidence: 99%

The Effect of TCM Syndrome Type and Western Medicine Detection on Patients with Hypertension and Diabetes Mellitus

Chen

Zhang

2022

Evidence-Based Complementary and Alternative Medicine

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“…The inflammatory state of T2DM patients played a stronger role in developing arteriosclerosis problems than the influence on CVD by obesity (70) . The C allele of FTO gene polymorphism rs7204609 contributed to genetic predisposition of chronic kidney disease (74) . Chronic kidney disease patients with central obesity, hypertension, high proteinuria and diabetes are more common than patients with chronic kidney disease alone.…”

Section: Fto and Diabetesmentioning

confidence: 99%

FTO: a critical role in obesity and obesity-related diseases

Yin

Liao

et al. 2023

Br J Nutr

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In recent years, obesity is a growing pandemic in the world and has likely contributed to increasing the incidence of obesity related diseases. Fat mass and obesity associated gene (FTO) is the first gene discovered which has close connection with fat. Recent studies suggested FTO gene has played an important role in the molecular mechanisms of many diseases. Obesity is considered to be a hereditary disease and it can evoke many kinds of diseases, including polycystic ovary syndrome (PCOS), type 2 diabetes mellitus (T2DM), cancer, etc., whose exact possible molecular mechanisms responsible for the effect of FTO on obesity and obesity related diseases remain largely unknown. In this review, we comprehensively discuss the correlation between FTO gene and obesity, cancer, PCOS, T2DM, as well as the molecular mechanism involved in these diseases.

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