Relationship Between the Levels of Oxidative Stress in Mesenteric and Peripheral Serum and Clinicopathological Variables in Colorectal Cancer

Yücel, Ahmet Fikret; Kemik, Özgür; Kemik, Ahu Sarbay; Pürisa, Sevim; Tüzün, İshak Sefa

doi:10.5152/balkanmedj.2011.035

Cited by 4 publications

(5 citation statements)

References 16 publications

(14 reference statements)

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“…A comprehensive study of 150 patients with CRC who underwent surgery analyzed OS parameters (MDA and 4-HNE) in peripheral and mesenteric blood according to four tumor stages (I-IV). The authors observed that levels of both OS markers increased with tumor stage [ 58 ], in line with previous results published by our group [ 28 ].…”

Section: Discussionsupporting

confidence: 89%

Oxidative Stress and DNA Damage Markers in Colorectal Cancer

Acevedo-León

Monzó-Beltrán

Pérez-Sánchez

et al. 2022

IJMS

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Oxidative stress (OS) and inflammation are known to play an important role in chronic diseases, including cancer, and specifically colorectal cancer (CRC). The main objective of this study was to explore the diagnostic potential of OS markers in patients with CRC, which may translate into an early diagnosis of the disease. To do this, we compared results with those in a group of healthy controls and assessed whether there were significant differences. In addition, we explored possible correlations with the presence of tumors and tumor stage, with anemia and with inflammatory markers used in clinical practice. The study included 80 patients with CRC and 60 healthy controls. The following OS markers were analyzed: catalase (CAT), reduced glutathione (GSH) and oxidized glutathione (GSSG) in serum; and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and F2-isoprotanes in urine (F2-IsoPs). Tumor markers (CEA and CA 19.9), anemia markers (hemoglobin, hematocrit and medium corpuscular volume) and inflammatory markers (leukocytes, neutrophils, N/L index, platelets, fibrinogen, C-reactive protein, CRP and IL-6) were also determined. Comparison of means between patients and controls revealed highly significant differences for all OS markers, with an increase in the prooxidant markers GSSG, GSSG/GSH ratio, 8-oxodG and F2-IsoPs, and a decrease in the antioxidant markers CAT and GSH. Tumor and inflammatory markers (except CRP) correlated positively with GSSG, GSSG/GSH ratio, 8-oxodG and F2-IsoPs, and negatively with CAT and GSH. In view of the results obtained, OS markers may constitute a useful tool for the early diagnosis of CRC patients.

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Section: Discussionsupporting

confidence: 89%

Oxidative Stress and DNA Damage Markers in Colorectal Cancer

Acevedo-León

Monzó-Beltrán

Pérez-Sánchez

et al. 2022

IJMS

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“…Free radicals and antioxidant can reinforce differing impacts on cells according to their concentration. Reactive oxygen species may participate in carcinogenesis through induction of gene mutations that result in cell damage and the consequences of signal transduction and transcription factors, and the redox status of cancer cells usually differs from that of normal cells [ 14 ]. Because of metabolic and signaling aberrations, cancer cells exhibit elevated ROS levels and it is balanced by an increased antioxidant capacity, which suggests that high ROS levels may constitute a barrier to tumorigenesis [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Blood and Tissue Enzymatic Activities of GDH and LDH, Index of Glutathione, and Oxidative Stress among Breast Cancer Patients Attending Referral Hospitals of Addis Ababa, Ethiopia: Hospital‐Based Comparative Cross‐Sectional Study

Mehdi

Menon

Seyoum

et al. 2018

Oxidative Medicine and Cellular Longevity

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The exact cause of breast cancer is unknown; it is a multifactorial disease. It is the most diagnosed and the second killer cancer among women. Breast cancer can be originated from tissues of breast or secondary from other organs via metastasis. Generally, cancer cells show aberrant metabolism and oxidative stress when compared to noncancerous tissues of breast cancer patients. The current study aims at evaluating glutamate and glucose metabolism through GDH and LDH enzyme activities, oxidant, and antioxidative status among breast cancer patients attending referral hospitals of Addis Ababa, Ethiopia. Result. Catalytic activities of glutamate dehydrogenase, lactate dehydrogenase, and oxidative stress index were significantly increased in both serum (4.2 mU/ml, 78.6 mU/ml, and 3.3 : 1, resp.) and cancerous tissues (1.4 mU/ml, 111.7 mU/ml, and 2.15 : 1, resp.) of breast cancer patients as compared to those in serum of control group (3.15 mU/ml, 30.4 mU/ml, and 2.05 : 1, resp.) and noncancerous tissues of breast cancer patients (0.92 mU/ml, 70.5 mU/ml, and 1.1 : 1, resp.) (P ≤ 0.05). Correspondingly, ratios of reduced to oxidized glutathione were significantly decreased in both serum (20 : 1) and cancerous tissues (23.5 : 1) of breast cancer patients when compared to those in serum of control group (104.5 : 1) and noncancerous tissues of breast cancer patients (70.9 : 1) (P ≤ 0.05). Conclusion. Catalytic activities of GDH and LDH, ratios of GSH to GSSG, and concentration of TOS among breast cancer patients were significantly higher than were those among control group and noncancerous tissues of breast cancer patients, while TAC of breast cancer patients is significantly lower than that of control group and normal tissues of breast cancer patients.

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“…estudos apontam que quanto maior o estadiamento menor concentração de antioxidantes enzimáticos, como superóxido dismutase, e não enzimáticos como vitamina e 10,[20][21] . além disso, foi observado que, em amostras sorológicas do mesentério e do peritônio de pacientes em estágios mais avançados, os níveis de Mda foram mais elevados quando comparados aos estágios iniciais em pacientes com câncer colorretal 12 . em um estudo de coorte, também foram encontradas concentrações mais elevadas de Mda em pacientes com câncer de cabeça e pescoço em estadiamento avançado em relação aos pacientes com estadiamentos iniciais, assim como os pacientes com níveis maiores de Mda tiveram pior prognóstico 22 .…”

Section: Discussionunclassified

“…da mesma forma, níveis significativamente mais baixos de marcadores antioxidantes não enzimáticos, como selênio e vitaminas antioxidantes, encontram-se reduzidos 11 . apesar de alguns estudos já demonstrarem uma tendência aos níveis de marcadores oxidantes, como o malondialdeído, serem maiores em amostras de pacientes com estágios mais avançados do câncer quando comparados aos em estágios iniciais 12,13 , ainda não há muitos estudos trazendo-o como marcador de resposta terapêutica no controle do estado de estresse oxidativo.…”

Section: Introductionunclassified

Interações entre Estresse Oxidativo, Terapia Utilizada e Estadiamento em Pacientes com Câncer Colorretal

Mendonça

Carioca²,

Maia

2014

Rev. Brasileira.De.Cancerologia

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Introdução: O malondialdeído (MDA) é um biomarcador importante na detecção do estresse oxidativo em amostras biológicas. Objetivo: Analisar a associação entre os níveis séricos de marcadores de estresse oxidativo, o estadiamento e terapia no câncer colorretal e compará-los com indivíduos saudáveis. Método: A amostra foi composta por 40 pacientes com câncer colorretal, recebendo radioterapia e realizando ou não quimioterapia, e 80 indivíduos saudáveis, recrutados em uma clínica especializada em Oncologia, no período de janeiro a junho de 2013. O estresse oxidativo foi analisado através da peroxida..o lipídica, que foi baseada nas espécies reativas ao ácido tiobarbitúrico (TBARS). Os resultados foram calculados de acordo com curva-padrão feita com malondialdeído. O estadiamento do câncer colorretal foi obtido dos prontuários dos pacientes. As análises estatísticas foram realizadas por meio dos testes exato de Fisher e Mann-Whitney, sendo o valor de p<0,05 definido como estatisticamente significante. Resultados: A concentração sérica de MDA (μM/L) foi de 4,1±2,9 no grupo com cancer e de 1,1±0,4 no grupo sem câncer (p=0,001). Em relação ao estadiamento do tumor, a média de MDA foi de 2,3±1,5 entre o grupo com estadiamento inicial (II) e de 5,4±3,0 entre o grupo com estadiamento avançado (III) (p<0,001). Não houve associação entre concentrações séricas de MDA e terapia realizada (p>0,05). Conclusão: As concentra..es séricas de malondialdeído foram superiores no grupo câncer em relação ao grupo sem câncer. Além disso, os níveis elevados de malondialdeído foram associados positivamente ao grau de estadiamento do tumor.

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Relationship Between the Levels of Oxidative Stress in Mesenteric and Peripheral Serum and Clinicopathological Variables in Colorectal Cancer

Cited by 4 publications

References 16 publications

Oxidative Stress and DNA Damage Markers in Colorectal Cancer

Oxidative Stress and DNA Damage Markers in Colorectal Cancer

Blood and Tissue Enzymatic Activities of GDH and LDH, Index of Glutathione, and Oxidative Stress among Breast Cancer Patients Attending Referral Hospitals of Addis Ababa, Ethiopia: Hospital‐Based Comparative Cross‐Sectional Study

Interações entre Estresse Oxidativo, Terapia Utilizada e Estadiamento em Pacientes com Câncer Colorretal

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