Relationship between the length of the uterine cavity and clinical pregnancy rates after in vitro fertilization or intracytoplasmic sperm injection

Chun, Sang Sik; Chung, Min Ji; Chong, Gun Oh; Park, Kee Sang; Lee, Taek Hoo

doi:10.1016/j.fertnstert.2009.08.067

Cited by 9 publications

(8 citation statements)

References 15 publications

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“…This is similar to Sang Sik Chun et al, who found that the correlation between length of the uterine cavity (measured from the fundus to external os) and pregnancy rates was positive, i.e ., longer uterine cavity lengths were associated with greater clinical pregnancy rates in IVF-ICSI patients. There is a good possibility that an increased uterine cavity length correlates with an endometrial volume increase, which contributes to higher pregnancy rates [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…IVF procedures, ovarian hyperstimulation regimens, and embryo transfer have all improved in recent years, but the pregnancy rates did not follow the upward trend. The quality of the embryo and the receptiveness of the endometrium are two of the most important variables in establishing pregnancy [ 2 ]. Good quality embryos and endometrium with high receptivity are both vital factors for human implantation to be successful [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Accuracy of endometrial length measurement in predicting IVF/ICSI outcome

Nayyef¹,

Abdullah

Al-Obaidi³

2022

JMedLife

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This study aimed to evaluate if endometrial length (EL) affects the likelihood of a positive pregnancy test in individuals who had in vitro fertilization/intra cytoplasmic sperm injection (IVF/ICSI). Between December 2020 and June 2021, 100 women from those referred to the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, for IVF/ICSI were selected. These women were 20–40 years old with primary type sub-fertility and met the inclusion criteria. Controlled ovarian hyperstimulation (antagonist protocol), followed by transvaginal sonography (TVS), was used to measure the endometrial length (EL) from the internal ostium to the fundus on the day of ovum collection. Afterwards, the association between endometrial length and the outcome was examined. The data were analyzed using the Statistical Package for Social Sciences (SPSS). The data show an important link between EL and treatment success. Endometrial length of ≥39 mm was considered a good cut-off point for IVF/ICSI pregnancy rates with a sensitivity of 75%, a specificity of 68%, a positive predictive value of 57%, and a negative predictive value of 83, and area under the curve of 0.81. An endometrial length of 39 mm can be used as an appropriate cut-off point in IVF/ICSI to predict a greater pregnancy rate. Vaginal sonography could be used in the ART cycle to measure the endometrial length and thickness and to determine endometrial receptiveness.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Accuracy of endometrial length measurement in predicting IVF/ICSI outcome

Nayyef¹,

Abdullah

Al-Obaidi³

2022

JMedLife

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“…12 With the advent of IVF, women with a unicornuate uterus with adequate uterine cavity have been able to achieve higher conception rates. 15 However, regardless of the method of conception, women with unicornuate uterus remain a high-risk obstetrical group. 16 Previous studies have reported rates for live birth of 29.2%, miscarriage of 29%, and premature birth of 44% (Akar et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Reproductive and neonatal outcomes in women with unicornuate uterus: a population-based study

Badeghiesh¹,

Vilos²,

Baghlaf³

et al. 2021

OGIJ

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Objective: To investigate reproductive and neonatal outcomes in women with unicornuate uterus. Study design: Data from the Health Care Cost and Utilization Project-Nationwide Inpatient Sample database were extracted from 2010 through 2014 to create a delivery cohort using ICD-9 codes. Code 752.33 was used to identify cases with unicornuate uterus and reproductive outcomes were compared to pregnancies without unicornuate uterus. A multivariate logistic regression model was used to adjust for statistically significant variables (P-value<0.05). Results: Among 3,850,226 deliveries during the study period, 802 women had unicornuate uterus. Patient with unicornuate uterus were more likely to be older (P<0.001), have thyroid disease (P<0.001), previous Caesarean section (P<0.001), and to have had in-vitro fertilization (IVF) (P<0.001). The risk of gestational diabetes, pregnancy induced hypertension, gestational hypertension and preeclampsia were significantly greater in the unicornuate uterus group relative to controls, after controlling for baseline risk factors; aOR 1.32 [95% CI 1.03–1.71], aOR 1.46 [95% CI 1.16–1.85], aOR 1.16 [95% CI 1.22-2.28] and aOR 1.70 [95% CI 1.24-2.32], respectively. Also, the rates of preterm delivery, preterm premature rupture of membranes and caesarean section were higher in the unicornuate uterus group compared to controls after controlling for confounding factors, aOR 3.83 (95% CI 3.19–4.6), aOR 5.11 (95% CI 3.73–7.14) and aOR 11.38 (95% CI 9.16–14.14) respectively. At birth, 11.1% and 2.6% of neonates were small for gestational age in the unicornuate uterus and the control groups, respectively, aOR 4.90, (95% CI 3.87-6.21). Conclusion: Women with unicornuate uterus are at higher risk for pregnancy complications, preterm delivery and having small for gestation age neonates. Women with known unicornuate uterus may benefit from increased surveillance to prevent and/or decrease maternal and neonate morbidity and mortality.

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“…Similarly, a prospective study found that US-GET does not enhance pregnancy rates compared with ET based on previous uterine length measurement ( Lambers et al , 2006 ). However, there seems to be a relation between uterine length and successful implantation ( Chun et al , 2010 ).…”

Section: Recommendationsmentioning

confidence: 99%

“…In cases of larger uterine cavities, the ET catheter end may not achieve ideal positioning towards the fundal end. Chun et al (2010) reported a possible higher miscarriage rate when the embryo bubble did not reach the highest point.…”

Section: Recommendationsmentioning

confidence: 99%

Evidence and consensus on technical aspects of embryo transfer

D’Angelo

Panayotidis²,

Alteri

et al. 2022

Human Reproduction Open

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BACKGROUND Ultrasound-guided embryo transfer (US-GET) is a widely performed procedure, but standards for the best practice are not available. OBJECTIVE AND RATIONALE This document aims to provide an overview of technical aspects of US-GET after considering the published data and including the preparation for the embryo transfer (ET) procedure, the actual procedure, the post-procedure care, associated pathologies, complications and risks, quality assurance and practitioners’ performance. SEARCH METHODS A literature search for evidence on key aspects of the ET procedure was carried out from database inception to November 2021. Selected papers (n = 359) relevant to the topic were analysed by the authors. The following key points were considered in the papers: whether ultrasound (US) practice standards were explained, to what extent the ET technique was described and whether complications or incidents and how to prevent such events were reported. In the end, 89 papers could be used to support the recommendations in this document, which focused on transabdominal US-GET. OUTCOMES The relevant papers found in the literature search were included in the current document and described according to the topic in three main sections: requirements and preparations prior to ET, the ET procedure, and training and competence for ET. Recommendations are provided on preparations prior to ET, equipment and materials, ET technique, possible risks and complications, training and competence. Specific aspects of the laboratory procedures are covered, in particular the different loading techniques and their potential impact on the final outcomes. Potential future developments and research priorities regarding the ET technique are also outlined. LIMITATIONS, REASONS FOR CAUTION Many topics were not covered in the literature review and some recommendations were based on expert opinions and are not necessarily evidence based. WIDER IMPLICATIONS ET is the last procedural step in an ART treatment and is a crucial step toward achieving a pregnancy and live birth. The current paper set out to bring together the recent developments considering all aspects of ET, especially emphasizing US quality imaging. There are still many questions needing answers, and these can be subject of future research. STUDY FUNDING/COMPETING INTEREST(S) No funding. ADA has received royalties from CRC Press and personal honorarium from Cook, Ferring and Cooper Surgical. The other co-authors have no conflicts of interest to declare that are relevant to the content of this article.

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Relationship between the length of the uterine cavity and clinical pregnancy rates after in vitro fertilization or intracytoplasmic sperm injection

Cited by 9 publications

References 15 publications

Accuracy of endometrial length measurement in predicting IVF/ICSI outcome

Accuracy of endometrial length measurement in predicting IVF/ICSI outcome

Reproductive and neonatal outcomes in women with unicornuate uterus: a population-based study

Evidence and consensus on technical aspects of embryo transfer

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