Relationship between the IL-10 (−1082 A/G) polymorphism and the risk of immune/idiopathic thrombocytopenic purpura: A meta-analysis

Ou, Yang; Yang, Yan; Xiang, Xinrong; Wu, Yuzhang

doi:10.1016/j.cyto.2019.154820

Cited by 8 publications

(7 citation statements)

References 34 publications

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“…32 Furthermore, IL-10 has been reported to affect immunological modulation in ITP 49,50 and might, therefore, be involved in the pathophysiology of ITP. 26,32,38 In this study, however, we observed no significant differences in IL-10 genotypes in ITP patients and healthy controls. This discrepancy between studies may be related to ethnic factors.…”

contrasting

confidence: 79%

“…[21][22][23] The distribution of single-nucleotide polymorphisms varies among different ethnic groups, which is also true specifically for polymorphisms in the cytokine-encoding genes related to ITP. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] However, there are few reports on the association of cytokine-related polymorphisms with responsiveness to TRAs in Japanese patients with ITP. Therefore, the associations between polymorphisms in cytokine-encoding genes and therapeutic responses to steroids and TRA in Japanese patients with ITP were investigated in the present study.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Cytokine Gene Polymorphisms on Eltrombopag Reactivity in Japanese Patients with Immune Thrombocytopenia

Nomura

Abe

Yamaoka

et al. 2021

JBM

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Background Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by low platelet counts resulting from antiplatelet autoantibodies. Analysis of polymorphisms in cytokine-encoding genes is important for understanding the pathophysiology of ITP and selecting appropriate treatments. We investigated associations between polymorphisms in cytokine-encoding genes and responses to therapy in Japanese patients with ITP. Methods The participants in this study comprised 153 patients with ITP and 70 healthy controls. We extracted data on sex, age, platelet counts, bleeding symptoms, and therapeutic responses, including those to prednisolone (PSL) and eltrombopag. Genomic DNA was isolated from peripheral blood and polymorphisms in TNF-α, IL-10, TGF-β 1 , and IFN-γ genes were analyzed using the PCR-SSP method. Results Our results showed that the TGF-β 1 +869 C/C genotype might be related to ITP in Japanese patients. The IL-10 −592 C/C and A/A, −819 C/C and T/T, and −1082, −819, −592 ATA/ATA genotypes might be associated with reactivity to PSL. Furthermore, the IL-10 −592 C/A −819 C/T genotypes, IL-10 ACC/ATA genotype, and TGF-β 1 +869 T/T and T/C genotypes might be linked to the response to eltrombopag. Conclusion Our results indicate that analysis of polymorphisms in cytokine-encoding genes could aid in understanding PSL and eltrombopag responsiveness in Japanese patients with ITP.

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contrasting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Effect of Cytokine Gene Polymorphisms on Eltrombopag Reactivity in Japanese Patients with Immune Thrombocytopenia

Nomura

Abe

Yamaoka

et al. 2021

JBM

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“…The possible involvement of this cytokine in ITP has been deeply investigated over the years. In particular, several authors found a correlation between the IL-10 (-1082) polymorphism, which is associated with an impairment in general cytokine release, and the acute form of ITP [36,37,38,39,40]. It is known that both CB1 and CB2 receptors can influence the production of IL-10.…”

Section: The Ec System In Immune Thrombocytopeniamentioning

confidence: 99%

The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases

Argenziano

Tortora

Bellini

et al. 2019

IJMS

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Endocannabinoid system consists of cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2) receptors, their endogenous ligands, and the enzymes responsible for their synthesis and degradation. CB2, to a great extent, and CB1, to a lesser extent, are involved in regulating the immune response. They also regulate the inflammatory processes by inhibiting pro-inflammatory mediator release and immune cell proliferation. This review provides an overview on the role of the endocannabinoid system with a major focus on cannabinoid receptors in the pathogenesis and onset of inflammatory and autoimmune pediatric diseases, such as immune thrombocytopenia, juvenile idiopathic arthritis, inflammatory bowel disease, celiac disease, obesity, neuroinflammatory diseases, and type 1 diabetes mellitus. These disorders have a high social impact and represent a burden for the healthcare system, hence the importance of individuating more innovative and effective treatments. The endocannabinoid system could address this need, representing a possible new diagnostic marker and therapeutic target.

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“…The analysis of polymorphisms in cytokine-encoding genes is important or understanding the pathophysiology and establishing appropriate treatment. 14 The distribution of single-nucleotide polymorphisms (SNPs) varies among different ethnic groups, which is also the case specifically for polymorphisms in cytokineencoding genes related to RA. 15,16 However, there have been few reports on cytokine-related polymorphisms in Japanese RA patients.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of Cytokine Gene Polymorphisms for the Therapeutic Choice in Japanese Patients with Rheumatoid Arthritis

Tsujimoto¹,

Ozaki²,

Ito³

et al. 2021

IJGM

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Background: Rheumatoid arthritis (RA) is characterized by systemic synovitis with bone erosion and joint cartilage degradation. Although the analysis of polymorphisms in cytokineencoding genes is important or understanding the pathophysiology of RA and selecting appropriate treatment for it, few studies have examined such single-nucleotide polymorphisms (SNPs) specifically in Japanese patients. This study was established to investigate the associations between polymorphisms in cytokine-encoding genes, autoantibodies and therapeutic responses in Japanese RA patients. Methods: The subjects in this study consisted of 100 RA patients and 50 healthy controls. We extracted data on sex, age, disease duration, rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) antibody, and therapeutic responses, including to methotrexate (MTX) and biological disease-modifying antirheumatic drugs (DMARDs). Genomic DNA was isolated from peripheral blood, which was genotyped for IL-10, TNF-α, TGF-β 1 , and IFN-γ polymorphisms. Results: Regarding IL-10 (−592 C/A and −819 C/T), significant decreases in the frequencies of the IL-10 (−592) CC genotype and (−819) CC genotype were found in RA patients compared with the levels in controls. For IFN-γ (+874 T/A), a significant decrease in the frequency of the TT genotype was found in RA patients compared with that in controls. Regarding TGF-β 1 (+869 T/C), patients with positivity for anti-CCP antibody had a significantly lower frequency of the CC genotype than those with negativity for it. Furthermore, the IL-10 (−592) CC genotype and (−819) CC genotype might be related to the biological DMARD-response. Conclusion:Our results suggest that the analysis of polymorphisms in cytokine-encoding genes may be useful when selecting treatment for Japanese RA patients.

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Relationship between the IL-10 (−1082 A/G) polymorphism and the risk of immune/idiopathic thrombocytopenic purpura: A meta-analysis

Cited by 8 publications

References 34 publications

Effect of Cytokine Gene Polymorphisms on Eltrombopag Reactivity in Japanese Patients with Immune Thrombocytopenia

Effect of Cytokine Gene Polymorphisms on Eltrombopag Reactivity in Japanese Patients with Immune Thrombocytopenia

The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases

Usefulness of Cytokine Gene Polymorphisms for the Therapeutic Choice in Japanese Patients with Rheumatoid Arthritis

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